Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000814538> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2000814538 endingPage "429" @default.
- W2000814538 startingPage "425" @default.
- W2000814538 abstract "ABSTRACT Islet amyloid polypeptide (IAPP) is a 37 amino acid peptide present in pancreatic β-cells. Pancreatic and circulating IAPP concentrations in rat models of diabetes were measured using a specific radioimmunoassay. Pancreatic IAPP-like immunoreactivity (IAPP-IR) in dexamethasone-treated rats was twice that of the control rats (1571±137 vs 657±176 ( s.e.m. ; n = 6) pmol/g), and this was reflected by similar changes in the plasma IAPP-IR (272±17 vs 102±10 pmol/l). In streptozotocin-treated rats, pancreatic IAPP-IR (200±90 pmol/g) was reduced compared with controls. There was a significant positive correlation between pancreatic and plasma IAPP-IR and insulin, with r values of 0·82 and 0·91 for the plasma and pancreas respectively. Characterization of pancreatic immunoreactivity, using gel chromatography, revealed two peaks of IAPP-IR, one which coeluted with synthetic human amidated IAPP and another peak, presumably a fragment or breakdown product, which eluted later. Chromatography of the plasma IAPP-IR revealed that >90% of the IAPP-IR eluted in the void volume, although the remaining IR coeluted with the synthetic IAPP standard. These results are not straightforwardly compatible with the suggested role for IAPP as a hormonal, paracrine or autocrine inhibitory regulator of insulin secretion in the maintenance of carbohydrate homeostasis. Journal of Endocrinology (1990) 126, 425–429" @default.
- W2000814538 created "2016-06-24" @default.
- W2000814538 creator A5011196462 @default.
- W2000814538 creator A5012049734 @default.
- W2000814538 creator A5025236550 @default.
- W2000814538 creator A5061251734 @default.
- W2000814538 creator A5069210140 @default.
- W2000814538 date "1990-09-01" @default.
- W2000814538 modified "2023-10-15" @default.
- W2000814538 title "Islet amyloid polypeptide-like immunoreactivity (amylin) in rats treated with dexamethasone and streptozotocin" @default.
- W2000814538 doi "https://doi.org/10.1677/joe.0.1260425" @default.
- W2000814538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2212934" @default.
- W2000814538 hasPublicationYear "1990" @default.
- W2000814538 type Work @default.
- W2000814538 sameAs 2000814538 @default.
- W2000814538 citedByCount "34" @default.
- W2000814538 countsByYear W20008145382012 @default.
- W2000814538 countsByYear W20008145382023 @default.
- W2000814538 crossrefType "journal-article" @default.
- W2000814538 hasAuthorship W2000814538A5011196462 @default.
- W2000814538 hasAuthorship W2000814538A5012049734 @default.
- W2000814538 hasAuthorship W2000814538A5025236550 @default.
- W2000814538 hasAuthorship W2000814538A5061251734 @default.
- W2000814538 hasAuthorship W2000814538A5069210140 @default.
- W2000814538 hasConcept C126322002 @default.
- W2000814538 hasConcept C134018914 @default.
- W2000814538 hasConcept C165220095 @default.
- W2000814538 hasConcept C179104552 @default.
- W2000814538 hasConcept C185592680 @default.
- W2000814538 hasConcept C2777391703 @default.
- W2000814538 hasConcept C2777633098 @default.
- W2000814538 hasConcept C2778108375 @default.
- W2000814538 hasConcept C2778563252 @default.
- W2000814538 hasConcept C2778764654 @default.
- W2000814538 hasConcept C2779280383 @default.
- W2000814538 hasConcept C2779306644 @default.
- W2000814538 hasConcept C2780705028 @default.
- W2000814538 hasConcept C3018667095 @default.
- W2000814538 hasConcept C555293320 @default.
- W2000814538 hasConcept C63645605 @default.
- W2000814538 hasConcept C71315377 @default.
- W2000814538 hasConcept C71924100 @default.
- W2000814538 hasConcept C86803240 @default.
- W2000814538 hasConceptScore W2000814538C126322002 @default.
- W2000814538 hasConceptScore W2000814538C134018914 @default.
- W2000814538 hasConceptScore W2000814538C165220095 @default.
- W2000814538 hasConceptScore W2000814538C179104552 @default.
- W2000814538 hasConceptScore W2000814538C185592680 @default.
- W2000814538 hasConceptScore W2000814538C2777391703 @default.
- W2000814538 hasConceptScore W2000814538C2777633098 @default.
- W2000814538 hasConceptScore W2000814538C2778108375 @default.
- W2000814538 hasConceptScore W2000814538C2778563252 @default.
- W2000814538 hasConceptScore W2000814538C2778764654 @default.
- W2000814538 hasConceptScore W2000814538C2779280383 @default.
- W2000814538 hasConceptScore W2000814538C2779306644 @default.
- W2000814538 hasConceptScore W2000814538C2780705028 @default.
- W2000814538 hasConceptScore W2000814538C3018667095 @default.
- W2000814538 hasConceptScore W2000814538C555293320 @default.
- W2000814538 hasConceptScore W2000814538C63645605 @default.
- W2000814538 hasConceptScore W2000814538C71315377 @default.
- W2000814538 hasConceptScore W2000814538C71924100 @default.
- W2000814538 hasConceptScore W2000814538C86803240 @default.
- W2000814538 hasIssue "3" @default.
- W2000814538 hasLocation W20008145381 @default.
- W2000814538 hasLocation W20008145382 @default.
- W2000814538 hasOpenAccess W2000814538 @default.
- W2000814538 hasPrimaryLocation W20008145381 @default.
- W2000814538 hasRelatedWork W1968759076 @default.
- W2000814538 hasRelatedWork W1999909300 @default.
- W2000814538 hasRelatedWork W2144429013 @default.
- W2000814538 hasRelatedWork W2144574657 @default.
- W2000814538 hasRelatedWork W2332569712 @default.
- W2000814538 hasRelatedWork W2591245970 @default.
- W2000814538 hasRelatedWork W2769903692 @default.
- W2000814538 hasRelatedWork W2783111266 @default.
- W2000814538 hasRelatedWork W3037619774 @default.
- W2000814538 hasRelatedWork W4296503608 @default.
- W2000814538 hasVolume "126" @default.
- W2000814538 isParatext "false" @default.
- W2000814538 isRetracted "false" @default.
- W2000814538 magId "2000814538" @default.
- W2000814538 workType "article" @default.