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• W2000815003 endingPage "297" @default.
• W2000815003 startingPage "255" @default.
• W2000815003 abstract "A new Schiff base thiosemicarbazone ligand with aqueous solubility, namely, sodium 3-{[(anilinocarbonothioyl)hydrazono]methyl}-4-hydroxy benzene sulfonate (NaH2L) was synthesized by condensation of 4-phenylthiosemicarbazide and sodium salicylaldehyde-5-sulfonate (NaSalSO3) and characterized by elemental analysis, spectroscopic methods (UV–Vis, 1H NMR, FTIR) and electrospray ionization mass spectrometry. A co-crystal (Na(H2L)·Na(SalSO3)) of NaH2L and NaSalSO3 was prepared which confirmed the expected structure of the ligand. Reactions of NaH2L·0.5H2O with copper(II), nickel(II), and zinc(II) acetates were investigated under reflux conditions in methanol to produce following complexes [Cu2(Lcycl)2(H2O)2]·2H2O (CuLcycl), Ni(HL)(H2O)3 (NiL), and Zn(HL)(H2O)3 (ZnL). In the copper case, dinuclear copper complex [Cu2(Lcycl)2(H2O)2]·2H2O (where HLcycl− represents incorporating of 1,3-benzothiazole ligand, formed by in situ cyclization of H2L−) was isolated. In the dimer structure copper atoms adopt a five-coordinate near square pyramidal geometry. Two oxygens derived from two sulfonate groups occupy the apical positions on both the metal centers and bridge them. The compounds have remarkable solubility in water at 25 °C: 50, 10, 50, and 50 g/L for NaH2L·0.5H2O, CuLcycl, NiL, and ZnL, respectively. The stability of the compounds was checked in acidic, neutral, and basic aqueous solutions. Antimicrobial activity results indicated CuLcycl and NiL possess activity against gram-positive bacteria and fungus while the free ligand and ZnL are inactive. Antioxidant activity of the compounds was evaluated and the ligand indicated the strongest radical scavenging relative to the complexes and l-ascorbic acid as a water-soluble standard. It was observed that copper and nickel complexes decreased the viability of the human chronic myeloid leukemia K562 cells in a dose- and time-dependent manner and the ligand and zinc complex were not active. The IC50 values were 31 ± 2.5 and 6 ± 1.0 μg/mL (72 h) for copper and nickel complexes, respectively. Morphological and DNA fragmentation assay studies clearly indicated that the nickel complex as the strongest compound induce apoptosis in the K562 cell line." @default.
• W2000815003 created "2016-06-24" @default.
• W2000815003 creator A5035020330 @default.
• W2000815003 creator A5073489847 @default.
• W2000815003 date "1981-01-01" @default.
• W2000815003 modified "2023-09-27" @default.
• W2000815003 title "Viral chemotherapy: Antiviral actions of metal ions and metal-chelating agents" @default.
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