FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000815740> ?p ?o ?g. }

• W2000815740 endingPage "220" @default.
• W2000815740 startingPage "203" @default.
• W2000815740 abstract "ABSTRACT This study determined the effects of intrauterine injections of recombinant ovine interferon-τ (roIFN-τ; 2 × 10 7 antiviral units/day) or control proteins (6 mg/day) from day 11 to day 14 post-oestrus (oestrus=day 0) on endometrial expression of receptors for oestrogen, progesterone and oxytocin in cyclic ewes. Plasma concentrations of progesterone were greater on day 15 in ewes receiving roIFN-τ compared with control proteins ( P <0·02, treatment × day). Ewes injected with roIFN-τ had lower endometrial levels of oestrogen receptor mRNA ( P <0·10) and protein ( P <0·01) on day 15 compared with ewes receiving control proteins. In situ hybridization analysis indicated that oestrogen receptor mRNA was more abundant in the luminal and glandular epithelium of control ewes compared with roIFN-τ-treated ewes. Immunoreactive oestrogen receptor was also present in the luminal and glandular epithelium of control, but not roIFN-τ-treated ewes. Endometrial levels of progesterone receptor mRNA and protein were not different ( P >0·10) between control and roIFN-τ-treated ewes. In situ hybridization analyses indicated that progesterone receptor mRNA abundance was low in endometrial epithelium and stroma of both control and roIFN-τ-injected ewes. Immunoreactive progesterone receptors were present in the endometrial stroma and epithelium of control ewes, but confined to the stroma of roIFN-τ-treated ewes. Oxytocin receptor density was lower ( P <0·10) in the endometrium of ewes injected with roIFN-τ than control proteins; however, oxytocin receptor affinity was not affected ( P >0·10) by treatment. Concentrations of 13,14-dihydro-15-keto-prostaglandin F 2α (PGFM) were not increased by exogenous oxytocin administration in control and roIFN-τ-treated ewes on days 10 or 12 post-oestrus. However, on day 14, control ewes responded to oxytocin with increased plasma concentrations of PGFM, whereas ewes receiving roIFN-τ remained unresponsive to oxytocin. These results indicate that the antiluteolytic effects of IFN-τ are to prevent increases in endometrial oestrogen receptor mRNA and protein and oxytocin receptor density which abrogates uterine release of prostaglandin F 2α during maternal recognition of pregnancy. IFN-τ may inhibit the synthesis of oestrogen receptor mRNA by a transcriptional or post-transcriptional regulatory mechanism to suppress oxytocin receptor formation during early pregnancy in ewes." @default.
• W2000815740 created "2016-06-24" @default.
• W2000815740 creator A5021286537 @default.
• W2000815740 creator A5043830065 @default.
• W2000815740 creator A5045794431 @default.
• W2000815740 creator A5047598837 @default.
• W2000815740 creator A5070300270 @default.
• W2000815740 creator A5076315257 @default.
• W2000815740 creator A5084539931 @default.
• W2000815740 creator A5089153101 @default.
• W2000815740 date "1995-10-01" @default.
• W2000815740 modified "2023-10-16" @default.
• W2000815740 title "Intrauterine injection of ovine interferon-τ alters oestrogen receptor and oxytocin receptor expression in the endometrium of cyclic ewes" @default.
• W2000815740 doi "https://doi.org/10.1677/jme.0.0150203" @default.
• W2000815740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8800645" @default.
• W2000815740 hasPublicationYear "1995" @default.
• W2000815740 type Work @default.
• W2000815740 sameAs 2000815740 @default.
• W2000815740 citedByCount "115" @default.
• W2000815740 countsByYear W20008157402012 @default.
• W2000815740 countsByYear W20008157402013 @default.
• W2000815740 countsByYear W20008157402014 @default.
• W2000815740 countsByYear W20008157402015 @default.
• W2000815740 countsByYear W20008157402016 @default.
• W2000815740 countsByYear W20008157402017 @default.
• W2000815740 countsByYear W20008157402018 @default.
• W2000815740 countsByYear W20008157402019 @default.
• W2000815740 countsByYear W20008157402020 @default.
• W2000815740 countsByYear W20008157402021 @default.
• W2000815740 countsByYear W20008157402023 @default.
• W2000815740 crossrefType "journal-article" @default.
• W2000815740 hasAuthorship W2000815740A5021286537 @default.
• W2000815740 hasAuthorship W2000815740A5043830065 @default.
• W2000815740 hasAuthorship W2000815740A5045794431 @default.
• W2000815740 hasAuthorship W2000815740A5047598837 @default.
• W2000815740 hasAuthorship W2000815740A5070300270 @default.
• W2000815740 hasAuthorship W2000815740A5076315257 @default.
• W2000815740 hasAuthorship W2000815740A5084539931 @default.
• W2000815740 hasAuthorship W2000815740A5089153101 @default.
• W2000815740 hasConcept C104317684 @default.
• W2000815740 hasConcept C105580179 @default.
• W2000815740 hasConcept C121608353 @default.
• W2000815740 hasConcept C126322002 @default.
• W2000815740 hasConcept C134018914 @default.
• W2000815740 hasConcept C170493617 @default.
• W2000815740 hasConcept C181612422 @default.
• W2000815740 hasConcept C1998276 @default.
• W2000815740 hasConcept C2776176026 @default.
• W2000815740 hasConcept C2779066055 @default.
• W2000815740 hasConcept C2779742232 @default.
• W2000815740 hasConcept C530470458 @default.
• W2000815740 hasConcept C55493867 @default.
• W2000815740 hasConcept C71924100 @default.
• W2000815740 hasConcept C81439078 @default.
• W2000815740 hasConcept C84606932 @default.
• W2000815740 hasConcept C86803240 @default.
• W2000815740 hasConcept C98717036 @default.
• W2000815740 hasConceptScore W2000815740C104317684 @default.
• W2000815740 hasConceptScore W2000815740C105580179 @default.
• W2000815740 hasConceptScore W2000815740C121608353 @default.
• W2000815740 hasConceptScore W2000815740C126322002 @default.
• W2000815740 hasConceptScore W2000815740C134018914 @default.
• W2000815740 hasConceptScore W2000815740C170493617 @default.
• W2000815740 hasConceptScore W2000815740C181612422 @default.
• W2000815740 hasConceptScore W2000815740C1998276 @default.
• W2000815740 hasConceptScore W2000815740C2776176026 @default.
• W2000815740 hasConceptScore W2000815740C2779066055 @default.
• W2000815740 hasConceptScore W2000815740C2779742232 @default.
• W2000815740 hasConceptScore W2000815740C530470458 @default.
• W2000815740 hasConceptScore W2000815740C55493867 @default.
• W2000815740 hasConceptScore W2000815740C71924100 @default.
• W2000815740 hasConceptScore W2000815740C81439078 @default.
• W2000815740 hasConceptScore W2000815740C84606932 @default.
• W2000815740 hasConceptScore W2000815740C86803240 @default.
• W2000815740 hasConceptScore W2000815740C98717036 @default.
• W2000815740 hasIssue "2" @default.
• W2000815740 hasLocation W20008157401 @default.
• W2000815740 hasOpenAccess W2000815740 @default.
• W2000815740 hasPrimaryLocation W20008157401 @default.
• W2000815740 hasRelatedWork W1968572327 @default.
• W2000815740 hasRelatedWork W1981195487 @default.
• W2000815740 hasRelatedWork W1988627537 @default.
• W2000815740 hasRelatedWork W1993415959 @default.
• W2000815740 hasRelatedWork W2067740242 @default.
• W2000815740 hasRelatedWork W2072753143 @default.
• W2000815740 hasRelatedWork W2087442723 @default.
• W2000815740 hasRelatedWork W2088618831 @default.
• W2000815740 hasRelatedWork W2092426612 @default.
• W2000815740 hasRelatedWork W2114431169 @default.
• W2000815740 hasVolume "15" @default.
• W2000815740 isParatext "false" @default.
• W2000815740 isRetracted "false" @default.
• W2000815740 magId "2000815740" @default.
• W2000815740 workType "article" @default.