Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000816237> ?p ?o ?g. }
- W2000816237 endingPage "1417" @default.
- W2000816237 startingPage "1410" @default.
- W2000816237 abstract "Clostridium difficile is a unique pathogen that often predominates in the bowel microflora as a result of the microbial compositional changes following antibiotic treatment. The hospital environment and patients undergoing antibiotic treatment provide a discrete ecosystem where C. difficile persists and where virulent clones thrive. The continued rise of C. difficile infection (CDI) worldwide has been accompanied by the rapid emergence and transcontinental spread of highly virulent clones, designated PCR-ribotypes 017, 027 and 078. These strains have risen from obscurity to become the most frequently isolated C. difficile strain types. Additionally, patients infected with these strains often experience more severe diarrhoea, more recurrent episodes and higher mortality. Although C. difficile appears to be evolving to occupy the hospital niche, community acquired CDI is also on the increase: equally changes in human activity are likely to be responsible for creating the microenvironment for C. difficile to thrive. The rapid worldwide spread of the 017, 027 and 078 clones of C. difficile provides a valuable opportunity to study the very recent emergence of a bacterial pathogen—a rare chance to monitor evolution in action." @default.
- W2000816237 created "2016-06-24" @default.
- W2000816237 creator A5023116254 @default.
- W2000816237 creator A5024128149 @default.
- W2000816237 creator A5026783065 @default.
- W2000816237 date "2009-12-01" @default.
- W2000816237 modified "2023-10-17" @default.
- W2000816237 title "Clostridium difficile—A continually evolving and problematic pathogen" @default.
- W2000816237 cites W140595635 @default.
- W2000816237 cites W1493602465 @default.
- W2000816237 cites W1565170002 @default.
- W2000816237 cites W1597663953 @default.
- W2000816237 cites W1801716289 @default.
- W2000816237 cites W1898462148 @default.
- W2000816237 cites W1912242285 @default.
- W2000816237 cites W1913442086 @default.
- W2000816237 cites W1964548259 @default.
- W2000816237 cites W1965674651 @default.
- W2000816237 cites W1966387420 @default.
- W2000816237 cites W1966505731 @default.
- W2000816237 cites W1973332267 @default.
- W2000816237 cites W1978510162 @default.
- W2000816237 cites W1980697150 @default.
- W2000816237 cites W1984565945 @default.
- W2000816237 cites W1984687595 @default.
- W2000816237 cites W1987193318 @default.
- W2000816237 cites W1995663075 @default.
- W2000816237 cites W2000755885 @default.
- W2000816237 cites W2001999329 @default.
- W2000816237 cites W2007890464 @default.
- W2000816237 cites W2012662786 @default.
- W2000816237 cites W2013285198 @default.
- W2000816237 cites W2020006158 @default.
- W2000816237 cites W2029621315 @default.
- W2000816237 cites W2029796480 @default.
- W2000816237 cites W2030331971 @default.
- W2000816237 cites W2031909807 @default.
- W2000816237 cites W2032233057 @default.
- W2000816237 cites W2035955155 @default.
- W2000816237 cites W2037149817 @default.
- W2000816237 cites W2038231155 @default.
- W2000816237 cites W2039760670 @default.
- W2000816237 cites W2042663308 @default.
- W2000816237 cites W2048566228 @default.
- W2000816237 cites W2052149039 @default.
- W2000816237 cites W2053735591 @default.
- W2000816237 cites W2057348977 @default.
- W2000816237 cites W2065215967 @default.
- W2000816237 cites W2073667393 @default.
- W2000816237 cites W2074934442 @default.
- W2000816237 cites W2083642829 @default.
- W2000816237 cites W2083793985 @default.
- W2000816237 cites W2084023168 @default.
- W2000816237 cites W2085700440 @default.
- W2000816237 cites W2089268884 @default.
- W2000816237 cites W2092135299 @default.
- W2000816237 cites W2093116438 @default.
- W2000816237 cites W2097154683 @default.
- W2000816237 cites W2097455186 @default.
- W2000816237 cites W2098525180 @default.
- W2000816237 cites W2099047627 @default.
- W2000816237 cites W2101902374 @default.
- W2000816237 cites W2102312968 @default.
- W2000816237 cites W2104518766 @default.
- W2000816237 cites W2104649869 @default.
- W2000816237 cites W2106831385 @default.
- W2000816237 cites W2106938218 @default.
- W2000816237 cites W2110397906 @default.
- W2000816237 cites W2110869848 @default.
- W2000816237 cites W2111416182 @default.
- W2000816237 cites W2112802172 @default.
- W2000816237 cites W2116954771 @default.
- W2000816237 cites W2118200177 @default.
- W2000816237 cites W2118529373 @default.
- W2000816237 cites W2119853161 @default.
- W2000816237 cites W2120051415 @default.
- W2000816237 cites W2125343055 @default.
- W2000816237 cites W2129366833 @default.
- W2000816237 cites W2131821874 @default.
- W2000816237 cites W2135900836 @default.
- W2000816237 cites W2137726039 @default.
- W2000816237 cites W2139509011 @default.
- W2000816237 cites W2139566520 @default.
- W2000816237 cites W2141951202 @default.
- W2000816237 cites W2142503351 @default.
- W2000816237 cites W2144447845 @default.
- W2000816237 cites W2144519105 @default.
- W2000816237 cites W2144646532 @default.
- W2000816237 cites W2148183380 @default.
- W2000816237 cites W2149230140 @default.
- W2000816237 cites W2149731870 @default.
- W2000816237 cites W2155278947 @default.
- W2000816237 cites W2158885600 @default.
- W2000816237 cites W2160292258 @default.
- W2000816237 cites W2160692001 @default.
- W2000816237 cites W2162304219 @default.
- W2000816237 cites W2163423623 @default.
- W2000816237 cites W2163501622 @default.