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• W2000817405 abstract "NUMEROUS reports as to the effect of X-ray and radium upon the spleen in various diseased conditions have appeared in the literature for a long period of time. This organ, forming, as it does, the largest lymphatic structure in the body, demonstrates the most marked evidence not only of local change, but also of general constitutional effects following the application of these agents. It is for this reason that X-ray and radium have been applied to the spleen in a great variety of diseases, such as the leukemias, splenic anemia, Hodgkin's disease, tuberculosis, and hemorrhage. The spleen has been recognized pathologically as one of the important habitats of the malaria plasmodium. In the disease, malaria, the organ is enlarged and deeply pigmented from the deposition of acid hemitin, or hematoidin, derived from the hemoglobin of the red blood cell by the action of the plasmodium malaria. Appreciating that X-ray and radium exert a remarkable influence upon all lymphatic structures in general and the spleen in particular and that this latter structure is an important focus in malarial infection, Pais (1), Cordier (2), Froes (3) and others have considered that X-ray and radium may form a valuable aid in the treatment of malaria. More especially would such a method be indicated in refractory cases of the disease, or in those patients, thus infected, having an idiosyncrasy to quinine. The results claimed by the above-mentioned authorities would indicate that X-ray has considerable value directly or indirectly in ameliorating the infection. With a view of determining whether or not X-ray or radium possesses a plasmodi-acidal effect it was considered advisable to test their action in various dosages directly upon the culture of plasmodium malariœ. It was the writer's good fortune to be able to procure such cultures from Professor Bass (4), who was the first worker to successfully cultivate the malarial plasmodium in vitro. Experimental Professor Bass, on October 16, 1922, procured blood from patient Lindsey (Ward 70, bed 2, Charity Hospital). Ten cubic centimeters of blood was drawn from the median basilic vein and 0.1 c.c. of 50 per cent solution of dextrose was immediately added. The blood was defibrinated by whipping. One cubic centimeter of this defibrinated blood containing plasmodia was placed in each of ten glass tubes in the usual way for cultivation of the malaria plasmodia. These glass tubes containing the living malarial parasites were then exposed to the X-ray, as follows: Tabe 1.Unfiltered X-rays; distance from target to culture tube 24 inches; spark gap of 6 inches; 4 ma.; time 4 minutes. Tabe 2.One mm. aluminum filter; distance from target to culture tube 24 inches; spark gap of 7 inches; 4 ma.; time 4 minutes. Tubes 4 and 5. Unfiltered rays; distance from target to culture tube 24 inches; spark gap 6 inches; 8 ma.; time 10 minutes." @default.
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• W2000817405 date "1924-11-01" @default.
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• W2000817405 title "Observation of the Effect of X-Ray and Radium Upon the Malarial ParasiteIn Vitro" @default.
• W2000817405 doi "https://doi.org/10.1148/3.5.399" @default.
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