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• W2000819340 abstract "Background Anti-tissue transglutaminase (tTG) antibody is being used increasingly as a diagnostic tool in the serological investigation of coeliac disease. However, positive predictive values of immunoglobulin A (IgA) anti-tTG for coeliac disease in prospective studies have been disappointing and false-positive results are reported. Objective To assess the clinical utility of cascade testing for anti-tTG and anti-endomysium antibody (AEA). Patients Two unselected retrospective cohorts from routine diagnostic investigation for possible gluten sensitive enteropathy: group 1 comprised 57 cases seropositive for anti-tTG and group 2 comprised 52 cases seronegative for anti-tTG. In both groups, all cases had also undergone small-intestinal biopsy. Methods Patients were assessed for the presence of IgA anti-tTG by enzyme-linked immunosorbent assay and for IgA AEA by immunofluorescence. Results The positive predictive value of IgA anti-tTG for biopsy-confirmed coeliac disease was 54%. The positive predictive value of dual positivity for anti-tTG and AEA was 97%. The negative predictive value of IgA anti-tTG was 100%. Conclusions The data presented here support the use of IgA anti-tTG as an initial screen for coeliac disease. Coeliac disease is unlikely when IgA anti-tTG is absent. However, many false-positive results are seen, and clinical utility and diagnostic efficiency are improved markedly if positive results are confirmed with the more accurate, but labour-intensive, AEA assay." @default.
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• W2000819340 date "2004-05-01" @default.
• W2000819340 modified "2023-09-26" @default.
• W2000819340 title "Is immunoglobulin A anti-tissue transglutaminase antibody a reliable serological marker of coeliac disease?" @default.
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• W2000819340 doi "https://doi.org/10.1097/00042737-200405000-00005" @default.
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