Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000819862> ?p ?o ?g. }
- W2000819862 endingPage "362" @default.
- W2000819862 startingPage "357" @default.
- W2000819862 abstract "Previous reports indicate that 7-ketocholesterol (7KCHO) induces apoptosis of cultured human vascular smooth muscle cells (SMCs). We hypothesized that calcium channel blockers will inhibit SMC apoptosis induced by 7KCHO because caspase-3 activity is Ca2+ dependent and 7KCHO stimulates caspase-3 and SMC apoptosis. So, the protective effect of the calcium channel blocker nifedipine on SMC apoptosis induced by 7KCHO was investigated. When 7KCHO (50 μmol/L) was added to SMCs, terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate (dUTP)-biotin nick end-labeling was positive. DNA extracted from SMCs exposed to 7KCHO showed a ladder pattern on agarose electrophoresis. In the presence of extracellular Ca2+, the Ca2+ influx, caspase-3 activity, and fragmented DNA also increased in SMCs incubated with 7KCHO dose-dependently. However, in the absence of extracellular Ca2+, no effects of 7KCHO on caspase-3 activity and fragmented DNA were observed. In the presence of nifedipine, the 7KCHO-induced increases in Ca2+ influx, caspase-3 activity, and the amount of fragmented DNA decreased significantly. These results suggest that 7KCHO-induced apoptosis of SMCs is inhibited by calcium channel blockade, and that Ca2+ influx into cells mediated by 7KCHO plays an important role in 7KCHO-induced apoptosis." @default.
- W2000819862 created "2016-06-24" @default.
- W2000819862 creator A5005795995 @default.
- W2000819862 creator A5013836679 @default.
- W2000819862 creator A5051237317 @default.
- W2000819862 creator A5076743693 @default.
- W2000819862 creator A5085870347 @default.
- W2000819862 date "2007-03-01" @default.
- W2000819862 modified "2023-09-27" @default.
- W2000819862 title "Vascular smooth muscle cell apoptosis induced by 7-ketocholesterol was mediated via Ca2+ and inhibited by the calcium channel blocker nifedipine" @default.
- W2000819862 cites W1968807800 @default.
- W2000819862 cites W1971441899 @default.
- W2000819862 cites W1971693731 @default.
- W2000819862 cites W1973107455 @default.
- W2000819862 cites W1987497023 @default.
- W2000819862 cites W1994299925 @default.
- W2000819862 cites W1995623147 @default.
- W2000819862 cites W2001024810 @default.
- W2000819862 cites W2016013493 @default.
- W2000819862 cites W2045441869 @default.
- W2000819862 cites W2051324266 @default.
- W2000819862 cites W2057692152 @default.
- W2000819862 cites W2071092830 @default.
- W2000819862 cites W2071744385 @default.
- W2000819862 cites W2075215763 @default.
- W2000819862 cites W2113574245 @default.
- W2000819862 cites W2116620721 @default.
- W2000819862 cites W2118440238 @default.
- W2000819862 cites W2144218981 @default.
- W2000819862 cites W2144529837 @default.
- W2000819862 cites W2170644229 @default.
- W2000819862 cites W2322308684 @default.
- W2000819862 cites W2326648943 @default.
- W2000819862 cites W2345423954 @default.
- W2000819862 cites W2412555968 @default.
- W2000819862 doi "https://doi.org/10.1016/j.metabol.2006.10.017" @default.
- W2000819862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17292724" @default.
- W2000819862 hasPublicationYear "2007" @default.
- W2000819862 type Work @default.
- W2000819862 sameAs 2000819862 @default.
- W2000819862 citedByCount "26" @default.
- W2000819862 countsByYear W20008198622012 @default.
- W2000819862 countsByYear W20008198622013 @default.
- W2000819862 countsByYear W20008198622014 @default.
- W2000819862 countsByYear W20008198622016 @default.
- W2000819862 countsByYear W20008198622017 @default.
- W2000819862 countsByYear W20008198622018 @default.
- W2000819862 countsByYear W20008198622019 @default.
- W2000819862 countsByYear W20008198622020 @default.
- W2000819862 crossrefType "journal-article" @default.
- W2000819862 hasAuthorship W2000819862A5005795995 @default.
- W2000819862 hasAuthorship W2000819862A5013836679 @default.
- W2000819862 hasAuthorship W2000819862A5051237317 @default.
- W2000819862 hasAuthorship W2000819862A5076743693 @default.
- W2000819862 hasAuthorship W2000819862A5085870347 @default.
- W2000819862 hasConcept C134018914 @default.
- W2000819862 hasConcept C153461711 @default.
- W2000819862 hasConcept C153911025 @default.
- W2000819862 hasConcept C178790620 @default.
- W2000819862 hasConcept C185592680 @default.
- W2000819862 hasConcept C190283241 @default.
- W2000819862 hasConcept C2778271344 @default.
- W2000819862 hasConcept C2779066535 @default.
- W2000819862 hasConcept C2779395532 @default.
- W2000819862 hasConcept C2780356492 @default.
- W2000819862 hasConcept C28406088 @default.
- W2000819862 hasConcept C2992686903 @default.
- W2000819862 hasConcept C519063684 @default.
- W2000819862 hasConcept C552990157 @default.
- W2000819862 hasConcept C55493867 @default.
- W2000819862 hasConcept C85520022 @default.
- W2000819862 hasConcept C86803240 @default.
- W2000819862 hasConcept C95444343 @default.
- W2000819862 hasConcept C98274493 @default.
- W2000819862 hasConceptScore W2000819862C134018914 @default.
- W2000819862 hasConceptScore W2000819862C153461711 @default.
- W2000819862 hasConceptScore W2000819862C153911025 @default.
- W2000819862 hasConceptScore W2000819862C178790620 @default.
- W2000819862 hasConceptScore W2000819862C185592680 @default.
- W2000819862 hasConceptScore W2000819862C190283241 @default.
- W2000819862 hasConceptScore W2000819862C2778271344 @default.
- W2000819862 hasConceptScore W2000819862C2779066535 @default.
- W2000819862 hasConceptScore W2000819862C2779395532 @default.
- W2000819862 hasConceptScore W2000819862C2780356492 @default.
- W2000819862 hasConceptScore W2000819862C28406088 @default.
- W2000819862 hasConceptScore W2000819862C2992686903 @default.
- W2000819862 hasConceptScore W2000819862C519063684 @default.
- W2000819862 hasConceptScore W2000819862C552990157 @default.
- W2000819862 hasConceptScore W2000819862C55493867 @default.
- W2000819862 hasConceptScore W2000819862C85520022 @default.
- W2000819862 hasConceptScore W2000819862C86803240 @default.
- W2000819862 hasConceptScore W2000819862C95444343 @default.
- W2000819862 hasConceptScore W2000819862C98274493 @default.
- W2000819862 hasIssue "3" @default.
- W2000819862 hasLocation W20008198621 @default.
- W2000819862 hasLocation W20008198622 @default.
- W2000819862 hasOpenAccess W2000819862 @default.
- W2000819862 hasPrimaryLocation W20008198621 @default.