FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000819908> ?p ?o ?g. }

• W2000819908 endingPage "223" @default.
• W2000819908 startingPage "215" @default.
• W2000819908 abstract "Despite the importance of intercellular lamellar bilayers for stratum corneum (SC) barrier function, knowledge about the structure of these bilayers is limited due to their poor visualization and/or retention. Whereas substitution of ruthenium tetroxide (RuO4) for osmium tetroxide fixation provides clear images of these bilayers, the usefulness of RuO4 has been limited by its slow penetration and cytotoxicity. Utilizing a new fixation protocol for RuO4, we obtained clear images of lamellar domains at all levels of murine SC. Computer-aided image reconstructions demonstrated a lamellar spacing of 129 +/- 2 A, which agreed with x-ray diffraction data from parallel, unfixed samples (131 +/- 2 A), a spacing not affected by hydration. Furthermore, novel structures were seen in the intercellular spaces of normal SC. Finally, in murine essential fatty acid deficiency (EFAD), the overall lamellar spacing is comparable to normal [127 +/- 7 A by computer transform vs. 131.9 +/- 2 A (hydrated) and 129.6 +/- 2.2 A (dry) by x-ray diffraction]. Yet, these domains are structurally abnormal, displaying regions with either an excess or absence of lamellae. The new RuO4 protocol provides quantitative information about SC lamellar dimensions and morphologic abnormalities in bilayer distribution and substructure in EFAD stratum corneum that are not detected by either x-ray diffraction or computer-aided image reconstruction. Thus, the barrier abnormality in EFAD stratum corneum can be ascribed either to focal depletion of lamellae or abnormalities in lamellar substructure." @default.
• W2000819908 created "2016-06-24" @default.
• W2000819908 creator A5024108946 @default.
• W2000819908 creator A5037090717 @default.
• W2000819908 creator A5050608918 @default.
• W2000819908 creator A5053094051 @default.
• W2000819908 creator A5055243730 @default.
• W2000819908 creator A5087724918 @default.
• W2000819908 date "1991-02-01" @default.
• W2000819908 modified "2023-10-01" @default.
• W2000819908 title "Membrane Structures in Normal and Essential Fatty Acid-Deficient Stratum Corneum: Characterization by Ruthenium Tetroxide Staining and X-Ray Diffraction" @default.
• W2000819908 cites W1217839427 @default.
• W2000819908 cites W1559999429 @default.
• W2000819908 cites W1975986537 @default.
• W2000819908 cites W1976938630 @default.
• W2000819908 cites W1980261854 @default.
• W2000819908 cites W1987203691 @default.
• W2000819908 cites W1988203671 @default.
• W2000819908 cites W1994207613 @default.
• W2000819908 cites W1996680206 @default.
• W2000819908 cites W2005090658 @default.
• W2000819908 cites W2016954164 @default.
• W2000819908 cites W2023624408 @default.
• W2000819908 cites W2024171233 @default.
• W2000819908 cites W2031958246 @default.
• W2000819908 cites W2032066103 @default.
• W2000819908 cites W2033921570 @default.
• W2000819908 cites W2034010541 @default.
• W2000819908 cites W2034723208 @default.
• W2000819908 cites W2039866201 @default.
• W2000819908 cites W2048861627 @default.
• W2000819908 cites W2053138332 @default.
• W2000819908 cites W2059346921 @default.
• W2000819908 cites W2060916590 @default.
• W2000819908 cites W2068410327 @default.
• W2000819908 cites W2069185355 @default.
• W2000819908 cites W2074392865 @default.
• W2000819908 cites W2101369093 @default.
• W2000819908 cites W2105113670 @default.
• W2000819908 cites W2169484065 @default.
• W2000819908 cites W2303771534 @default.
• W2000819908 doi "https://doi.org/10.1111/1523-1747.ep12461361" @default.
• W2000819908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1991982" @default.
• W2000819908 hasPublicationYear "1991" @default.
• W2000819908 type Work @default.
• W2000819908 sameAs 2000819908 @default.
• W2000819908 citedByCount "286" @default.
• W2000819908 countsByYear W20008199082012 @default.
• W2000819908 countsByYear W20008199082013 @default.
• W2000819908 countsByYear W20008199082014 @default.
• W2000819908 countsByYear W20008199082015 @default.
• W2000819908 countsByYear W20008199082016 @default.
• W2000819908 countsByYear W20008199082017 @default.
• W2000819908 countsByYear W20008199082018 @default.
• W2000819908 countsByYear W20008199082019 @default.
• W2000819908 countsByYear W20008199082020 @default.
• W2000819908 countsByYear W20008199082021 @default.
• W2000819908 countsByYear W20008199082022 @default.
• W2000819908 countsByYear W20008199082023 @default.
• W2000819908 crossrefType "journal-article" @default.
• W2000819908 hasAuthorship W2000819908A5024108946 @default.
• W2000819908 hasAuthorship W2000819908A5037090717 @default.
• W2000819908 hasAuthorship W2000819908A5050608918 @default.
• W2000819908 hasAuthorship W2000819908A5053094051 @default.
• W2000819908 hasAuthorship W2000819908A5055243730 @default.
• W2000819908 hasAuthorship W2000819908A5087724918 @default.
• W2000819908 hasConcept C105702510 @default.
• W2000819908 hasConcept C120665830 @default.
• W2000819908 hasConcept C121332964 @default.
• W2000819908 hasConcept C12554922 @default.
• W2000819908 hasConcept C145156650 @default.
• W2000819908 hasConcept C185592680 @default.
• W2000819908 hasConcept C192157962 @default.
• W2000819908 hasConcept C192562407 @default.
• W2000819908 hasConcept C2778370115 @default.
• W2000819908 hasConcept C2779424567 @default.
• W2000819908 hasConcept C41625074 @default.
• W2000819908 hasConcept C54355233 @default.
• W2000819908 hasConcept C55493867 @default.
• W2000819908 hasConcept C77851909 @default.
• W2000819908 hasConcept C8010536 @default.
• W2000819908 hasConcept C86803240 @default.
• W2000819908 hasConcept C87555872 @default.
• W2000819908 hasConcept C93877712 @default.
• W2000819908 hasConceptScore W2000819908C105702510 @default.
• W2000819908 hasConceptScore W2000819908C120665830 @default.
• W2000819908 hasConceptScore W2000819908C121332964 @default.
• W2000819908 hasConceptScore W2000819908C12554922 @default.
• W2000819908 hasConceptScore W2000819908C145156650 @default.
• W2000819908 hasConceptScore W2000819908C185592680 @default.
• W2000819908 hasConceptScore W2000819908C192157962 @default.
• W2000819908 hasConceptScore W2000819908C192562407 @default.
• W2000819908 hasConceptScore W2000819908C2778370115 @default.
• W2000819908 hasConceptScore W2000819908C2779424567 @default.
• W2000819908 hasConceptScore W2000819908C41625074 @default.
• W2000819908 hasConceptScore W2000819908C54355233 @default.
• W2000819908 hasConceptScore W2000819908C55493867 @default.
• W2000819908 hasConceptScore W2000819908C77851909 @default.

• next