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• W2000822037 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 May 2001CORPOREAL STRUCTURAL AND VASCULAR MICRO ARCHITECTURE WITH X-RAY MICRO COMPUTERIZED TOMOGRAPHY IN NORMAL AND DIABETIC RABBITS: HISTOPATHOLOGICAL CORRELATION DEMETRIOS N. SIMOPOULOS, SIMON J. GIBBONS, JOHN MALYSZ, JOSEPH H. SZURSZEWSKI, GIANRICO FARRUGIA, ERIK L. RITMAN, ROBERT B. MORELAND, and AJAY NEHRA DEMETRIOS N. SIMOPOULOSDEMETRIOS N. SIMOPOULOS More articles by this author , SIMON J. GIBBONSSIMON J. GIBBONS More articles by this author , JOHN MALYSZJOHN MALYSZ More articles by this author , JOSEPH H. SZURSZEWSKIJOSEPH H. SZURSZEWSKI More articles by this author , GIANRICO FARRUGIAGIANRICO FARRUGIA More articles by this author , ERIK L. RITMANERIK L. RITMAN More articles by this author , ROBERT B. MORELANDROBERT B. MORELAND More articles by this author , and AJAY NEHRAAJAY NEHRA More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)66413-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The pathophysiology of diabetes mellitus induced erectile dysfunction is poorly understood. In patients with diffuse venous leakage structural changes in the corpora cavernosa have correlated with failure of the veno-occlusive mechanism. Three-dimensional (D) micro computerized tomography (CT) has proved to be an important imaging technique for the intact kidney, heart, liver and bone. We examined control and diabetic rabbit penises by 3-D micro CT and quantified any structural changes. Materials and Methods: Male white New Zealand rabbits were treated with alloxan to induce diabetes or used as normal controls. Via aortic access at laparotomy the penile vascular tree was vasodilated with papaverine and perfused with radiopaque silicone rubber. X-ray micro CT was then performed at 21 μm. resolution and images were analyzed in 3-D using custom software. Results: Nine diabetic rabbits with blood glucose greater than 400 mg./dl. and 9 control animals were used for micro CT analysis. Significant decreases (p <0.05) were observed in the mean sinusoidal and vascular volume fraction plus or minus standard error of mean of the corpus cavernosum in the diabetic (323.7 ± 43.1 mm.3 and 37.9 ± 2.0%, respectively) and control (510.1 ± 47.4 mm.3 and 53.1 ± 3.80%, respectively) groups. Also, the mean left and right cavernous artery luminal cross-sectional area in diabetics (0.15 ± 0.02 and 0.16 ± 0.01 mm.2, respectively) versus controls (0.2 ± 0.01 and 0.2 ± 0.01 mm.2, respectively) was significantly decreased (p <0.05). Furthermore, the mean left and right total cavernous artery luminal volume in diabetics (0.4 ± 0.07 and 0.4 ± 0.09 mm.3, respectively) versus controls (1.0 ± 0.13 and 0.9 ± 0.11 mm.3, respectively) was significantly decreased (p <0.05). Conclusions: Diabetic rabbit penises showed a significant decrease in corporeal vascular volume as well as decreased cavernous artery diameter and luminal volume compared to controls. This finding correlated well with the mean decrease in trabecular smooth muscle in control and severely diabetic rabbits on histopathological studies (42.2% ± 1.5% versus 35.8% ± 1.5%). This combination of potential arterial insufficiency as well as an increase in diffuse connective tissue may contribute to the overall pathophysiology of diabetic erectile dysfunction. These results suggest that 3-D x-ray micro CT with molecular analysis may be a powerful tool for examining the pathophysiology of diabetic erectile dysfunction. 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Google Scholar From the Departments of Urology, Physiology and Radiology, Mayo Clinic, Rochester, Minnesota, and Departments of Urology and Physiology, Boston University School of Medicine, Boston, Massachusetts© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 165Issue 5May 2001Page: 1776-1782 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsrabbitstomography, x-ray computedpenisdiabetes mellitusimpotenceMetricsAuthor Information DEMETRIOS N. SIMOPOULOS More articles by this author SIMON J. GIBBONS More articles by this author JOHN MALYSZ More articles by this author JOSEPH H. SZURSZEWSKI More articles by this author GIANRICO FARRUGIA More articles by this author ERIK L. RITMAN More articles by this author ROBERT B. MORELAND More articles by this author AJAY NEHRA More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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