FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000823493> ?p ?o ?g. }

• W2000823493 endingPage "1727" @default.
• W2000823493 startingPage "1722" @default.
• W2000823493 abstract "In mammals, one of the key regulators necessary for responding to genotoxic stress is the p53 transcription factor. p53 is the single most commonly mutated tumor suppressor gene in human cancers [1Hussain S.P. Harris C.C. Molecular epidemiology and carcinogenesis endogenous and exogenous carcinogens.Mutat Res. 2000; 462: 311-322Crossref PubMed Scopus (97) Google Scholar]. Here we report the identification of a C. elegans homolog of mammalian p53. Using RNAi and DNA cosuppression technology, we show that C. elegans p53 (cep-1) is required for DNA damage-induced apoptosis in the C. elegans germline. However,cep-1 RNAi does not affect programmed cell death occurring during worm development and physiological (radiation-independent) germ cell death. The DNA binding domain of CEP-1 is related to vertebrate p53 members and possesses the conserved residues most frequently mutated in human tumors. Consistent with this, CEP-1 acts as a transcription factor and is able to activate a transcriptional reporter containing consensus human p53 binding sites. Our data support the notion that p53-mediated transcriptional regulation is part of an ancestral pathway mediating DNA damage-induced apoptosis and reveals C. elegans as a genetically tractable model organism for studying the p53 apoptotic pathway." @default.
• W2000823493 created "2016-06-24" @default.
• W2000823493 creator A5015519563 @default.
• W2000823493 creator A5024718667 @default.
• W2000823493 creator A5062040602 @default.
• W2000823493 creator A5091323966 @default.
• W2000823493 date "2001-10-01" @default.
• W2000823493 modified "2023-10-11" @default.
• W2000823493 title "The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis" @default.
• W2000823493 cites W1978518304 @default.
• W2000823493 cites W1984755213 @default.
• W2000823493 cites W1997199912 @default.
• W2000823493 cites W2012183441 @default.
• W2000823493 cites W2021312899 @default.
• W2000823493 cites W2025137885 @default.
• W2000823493 cites W2038988292 @default.
• W2000823493 cites W2039555878 @default.
• W2000823493 cites W2043107604 @default.
• W2000823493 cites W2043470536 @default.
• W2000823493 cites W2059666350 @default.
• W2000823493 cites W2067920944 @default.
• W2000823493 cites W2072366190 @default.
• W2000823493 cites W2076676971 @default.
• W2000823493 cites W2096005449 @default.
• W2000823493 cites W2096276671 @default.
• W2000823493 cites W2115204806 @default.
• W2000823493 cites W2117521691 @default.
• W2000823493 cites W2118270653 @default.
• W2000823493 cites W2127244622 @default.
• W2000823493 cites W2128041433 @default.
• W2000823493 cites W2128491398 @default.
• W2000823493 cites W2128709215 @default.
• W2000823493 cites W2142305917 @default.
• W2000823493 cites W2155640249 @default.
• W2000823493 cites W2332617654 @default.
• W2000823493 cites W4230501579 @default.
• W2000823493 cites W4241031272 @default.
• W2000823493 doi "https://doi.org/10.1016/s0960-9822(01)00534-6" @default.
• W2000823493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11696333" @default.
• W2000823493 hasPublicationYear "2001" @default.
• W2000823493 type Work @default.
• W2000823493 sameAs 2000823493 @default.
• W2000823493 citedByCount "321" @default.
• W2000823493 countsByYear W20008234932012 @default.
• W2000823493 countsByYear W20008234932013 @default.
• W2000823493 countsByYear W20008234932014 @default.
• W2000823493 countsByYear W20008234932015 @default.
• W2000823493 countsByYear W20008234932016 @default.
• W2000823493 countsByYear W20008234932017 @default.
• W2000823493 countsByYear W20008234932018 @default.
• W2000823493 countsByYear W20008234932019 @default.
• W2000823493 countsByYear W20008234932020 @default.
• W2000823493 countsByYear W20008234932021 @default.
• W2000823493 countsByYear W20008234932022 @default.
• W2000823493 countsByYear W20008234932023 @default.
• W2000823493 crossrefType "journal-article" @default.
• W2000823493 hasAuthorship W2000823493A5015519563 @default.
• W2000823493 hasAuthorship W2000823493A5024718667 @default.
• W2000823493 hasAuthorship W2000823493A5062040602 @default.
• W2000823493 hasAuthorship W2000823493A5091323966 @default.
• W2000823493 hasBestOaLocation W20008234931 @default.
• W2000823493 hasConcept C104317684 @default.
• W2000823493 hasConcept C109825262 @default.
• W2000823493 hasConcept C138885662 @default.
• W2000823493 hasConcept C143425029 @default.
• W2000823493 hasConcept C166703698 @default.
• W2000823493 hasConcept C179185449 @default.
• W2000823493 hasConcept C179926584 @default.
• W2000823493 hasConcept C190283241 @default.
• W2000823493 hasConcept C2778264664 @default.
• W2000823493 hasConcept C2778944004 @default.
• W2000823493 hasConcept C31573885 @default.
• W2000823493 hasConcept C41895202 @default.
• W2000823493 hasConcept C54355233 @default.
• W2000823493 hasConcept C552990157 @default.
• W2000823493 hasConcept C555283112 @default.
• W2000823493 hasConcept C67705224 @default.
• W2000823493 hasConcept C86339819 @default.
• W2000823493 hasConcept C86803240 @default.
• W2000823493 hasConcept C95444343 @default.
• W2000823493 hasConceptScore W2000823493C104317684 @default.
• W2000823493 hasConceptScore W2000823493C109825262 @default.
• W2000823493 hasConceptScore W2000823493C138885662 @default.
• W2000823493 hasConceptScore W2000823493C143425029 @default.
• W2000823493 hasConceptScore W2000823493C166703698 @default.
• W2000823493 hasConceptScore W2000823493C179185449 @default.
• W2000823493 hasConceptScore W2000823493C179926584 @default.
• W2000823493 hasConceptScore W2000823493C190283241 @default.
• W2000823493 hasConceptScore W2000823493C2778264664 @default.
• W2000823493 hasConceptScore W2000823493C2778944004 @default.
• W2000823493 hasConceptScore W2000823493C31573885 @default.
• W2000823493 hasConceptScore W2000823493C41895202 @default.
• W2000823493 hasConceptScore W2000823493C54355233 @default.
• W2000823493 hasConceptScore W2000823493C552990157 @default.
• W2000823493 hasConceptScore W2000823493C555283112 @default.
• W2000823493 hasConceptScore W2000823493C67705224 @default.
• W2000823493 hasConceptScore W2000823493C86339819 @default.
• W2000823493 hasConceptScore W2000823493C86803240 @default.

• next