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- W2000824373 endingPage "109" @default.
- W2000824373 startingPage "103" @default.
- W2000824373 abstract "Many mammalian organs undergo branching morphogenesis to create highly arborized structures with maximized surface area for specialized organ function. Cooperative cell–cell and cell–matrix adhesions that sculpt the emerging tissue architecture are guided by dynamic basement membranes. Properties of the basement membrane are reciprocally controlled by the interacting epithelial and mesenchymal cell populations. Here we discuss how basement membrane remodeling is required for branching morphogenesis to regulate cell–matrix and cell–cell adhesions that are required for cell patterning during morphogenesis and how basement membrane impacts morphogenesis by stimulation of cell patterning, force generation, and mechanotransduction. We suggest that in addition to creating mature epithelial architecture, remodeling of the epithelial basement membrane during branching morphogenesis is also essential to promote maturation of the stromal mesenchyme to create mature organ structure. Recapitulation of developmental cell–matrix and cell–cell interactions are of critical importance in tissue engineering and regeneration strategies that seek to restore organ function." @default.
- W2000824373 created "2016-06-24" @default.
- W2000824373 creator A5086091273 @default.
- W2000824373 creator A5087618896 @default.
- W2000824373 date "2015-05-01" @default.
- W2000824373 modified "2023-09-26" @default.
- W2000824373 title "Heterotypic control of basement membrane dynamics during branching morphogenesis" @default.
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