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- W2000827121 abstract "To study the effects of antiglaucoma eye drops on N-methyl-d-aspartate (NMDA)-induced retinal damage. Several antiglaucoma eye drops, β-blockers, α/β-blockers, an α1-blocker, an α2-agonist, and a prostaglandin derivative, were topically administrated to NMDA-treated rat eyes daily for 2 weeks, and the retinal thickness, the number of retrograde-labeled retinal ganglion cells (RGCs), and the results of a cDNA microarray analysis were studied. Intravitreal administration of NMDA caused a significant decrease in the thickness of the retinal layers and induced upregulation of glial fibrillary acidic protein (GFAP). Topical administration of β-blockers (timolol, betaxolol, and carteolol) and a prostaglandin derivative (latanoprost) showed almost no significant effects on retinal thickness, the number of RGCs, or expression of GFAP. In contrast, the α/β-blockers (nipradilol and levobunolol), the α1-blocker (bunazosin HCl), and the α2-agonist (brimonidine) showed preservation effects on retinal thickness and the number of RGCs, and marked suppression of NMDA-induced upregulation of GFAP. Among 1101 genes related to cellular regulatory mechanisms, the expression of two genes, both for insulin-like growth factors, (IGF-1) and ErbB3, was altered upon administration of the α/β-blockers, the α1-blocker, and the α2-agonist. Our present study suggests that modulations of the α-adrenergic receptor, α1-blocking and α2-stimulation, by antiglaucoma eye drops may cause beneficial effects on NMDA-induced retinal damage in the rat. Jpn J Ophthalmol 2005;49:453–461 © Japanese Ophthalmological Society 2005" @default.
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- W2000827121 date "2005-11-01" @default.
- W2000827121 modified "2023-09-26" @default.
- W2000827121 title "Study of Effects of Antiglaucoma Eye Drops on N-Methyl-d-Aspartate-Induced Retinal Damage" @default.
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- W2000827121 doi "https://doi.org/10.1007/s10384-005-0253-5" @default.
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