FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000827155> ?p ?o ?g. }

• W2000827155 endingPage "1212" @default.
• W2000827155 startingPage "1205" @default.
• W2000827155 abstract "The ability to specifically reactivate epigenetically silenced genes would have great utility in experimental studies and potential therapeutic value. Here, we describe the specific targeting of thymidine DNA glycosylase (TDG), an enzyme involved in the mechanism of methylcytosine demethylation, to the promoter of Nos2, a gene silenced by methylation in fibroblasts, using artificial zinc finger DNA binding domains. Individual targeted TDG constructs had a small effect on Nos2 expression and methylation, but simultaneous targeting of a quartet of TDG constructs significantly restored responsiveness to LPS and IFN stimuli in association with marked cytosine demethylation at the promoter and CpG island; catalytically inactive TDG complexes had no effect. Whole-genome expression microarray and pathway analysis found only 42 genes that were affected by targeted TDG constructs; the majority are likely downstream of the effect on Nos2. This study therefore shows highly specific, directed reactivation of a single, silenced gene by targeting of a demethylase to the promoter." @default.
• W2000827155 created "2016-06-24" @default.
• W2000827155 creator A5015725871 @default.
• W2000827155 creator A5048817987 @default.
• W2000827155 creator A5052878737 @default.
• W2000827155 creator A5061316293 @default.
• W2000827155 date "2013-11-01" @default.
• W2000827155 modified "2023-10-14" @default.
• W2000827155 title "Specific transcriptional enhancement of inducible nitric oxide synthase by targeted promoter demethylation" @default.
• W2000827155 cites W1560571961 @default.
• W2000827155 cites W1901685637 @default.
• W2000827155 cites W1967064280 @default.
• W2000827155 cites W2000625273 @default.
• W2000827155 cites W2022405729 @default.
• W2000827155 cites W2038449573 @default.
• W2000827155 cites W2038700261 @default.
• W2000827155 cites W2062211740 @default.
• W2000827155 cites W2086575542 @default.
• W2000827155 cites W2117856901 @default.
• W2000827155 cites W2120605137 @default.
• W2000827155 cites W2124509992 @default.
• W2000827155 cites W2127808005 @default.
• W2000827155 cites W2129289657 @default.
• W2000827155 cites W2130069008 @default.
• W2000827155 cites W2135832165 @default.
• W2000827155 cites W2156559492 @default.
• W2000827155 cites W2158998217 @default.
• W2000827155 cites W2161224111 @default.
• W2000827155 cites W2165673819 @default.
• W2000827155 cites W2170099595 @default.
• W2000827155 cites W4254220742 @default.
• W2000827155 doi "https://doi.org/10.4161/epi.26267" @default.
• W2000827155 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5845820" @default.
• W2000827155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24008769" @default.
• W2000827155 hasPublicationYear "2013" @default.
• W2000827155 type Work @default.
• W2000827155 sameAs 2000827155 @default.
• W2000827155 citedByCount "38" @default.
• W2000827155 countsByYear W20008271552014 @default.
• W2000827155 countsByYear W20008271552015 @default.
• W2000827155 countsByYear W20008271552016 @default.
• W2000827155 countsByYear W20008271552017 @default.
• W2000827155 countsByYear W20008271552018 @default.
• W2000827155 countsByYear W20008271552019 @default.
• W2000827155 countsByYear W20008271552020 @default.
• W2000827155 countsByYear W20008271552021 @default.
• W2000827155 countsByYear W20008271552022 @default.
• W2000827155 countsByYear W20008271552023 @default.
• W2000827155 crossrefType "journal-article" @default.
• W2000827155 hasAuthorship W2000827155A5015725871 @default.
• W2000827155 hasAuthorship W2000827155A5048817987 @default.
• W2000827155 hasAuthorship W2000827155A5052878737 @default.
• W2000827155 hasAuthorship W2000827155A5061316293 @default.
• W2000827155 hasBestOaLocation W20008271551 @default.
• W2000827155 hasConcept C101762097 @default.
• W2000827155 hasConcept C104317684 @default.
• W2000827155 hasConcept C140173407 @default.
• W2000827155 hasConcept C150194340 @default.
• W2000827155 hasConcept C153911025 @default.
• W2000827155 hasConcept C165864922 @default.
• W2000827155 hasConcept C16824249 @default.
• W2000827155 hasConcept C190727270 @default.
• W2000827155 hasConcept C202199734 @default.
• W2000827155 hasConcept C2781364455 @default.
• W2000827155 hasConcept C33288867 @default.
• W2000827155 hasConcept C41091548 @default.
• W2000827155 hasConcept C54355233 @default.
• W2000827155 hasConcept C552990157 @default.
• W2000827155 hasConcept C86803240 @default.
• W2000827155 hasConcept C95444343 @default.
• W2000827155 hasConceptScore W2000827155C101762097 @default.
• W2000827155 hasConceptScore W2000827155C104317684 @default.
• W2000827155 hasConceptScore W2000827155C140173407 @default.
• W2000827155 hasConceptScore W2000827155C150194340 @default.
• W2000827155 hasConceptScore W2000827155C153911025 @default.
• W2000827155 hasConceptScore W2000827155C165864922 @default.
• W2000827155 hasConceptScore W2000827155C16824249 @default.
• W2000827155 hasConceptScore W2000827155C190727270 @default.
• W2000827155 hasConceptScore W2000827155C202199734 @default.
• W2000827155 hasConceptScore W2000827155C2781364455 @default.
• W2000827155 hasConceptScore W2000827155C33288867 @default.
• W2000827155 hasConceptScore W2000827155C41091548 @default.
• W2000827155 hasConceptScore W2000827155C54355233 @default.
• W2000827155 hasConceptScore W2000827155C552990157 @default.
• W2000827155 hasConceptScore W2000827155C86803240 @default.
• W2000827155 hasConceptScore W2000827155C95444343 @default.
• W2000827155 hasIssue "11" @default.
• W2000827155 hasLocation W20008271551 @default.
• W2000827155 hasLocation W20008271552 @default.
• W2000827155 hasLocation W20008271553 @default.
• W2000827155 hasLocation W20008271554 @default.
• W2000827155 hasOpenAccess W2000827155 @default.
• W2000827155 hasPrimaryLocation W20008271551 @default.
• W2000827155 hasRelatedWork W1996104664 @default.
• W2000827155 hasRelatedWork W2004562860 @default.
• W2000827155 hasRelatedWork W2015951593 @default.
• W2000827155 hasRelatedWork W2033874367 @default.
• W2000827155 hasRelatedWork W2037263033 @default.

• next