Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000829058> ?p ?o ?g. }
- W2000829058 endingPage "1056" @default.
- W2000829058 startingPage "1051" @default.
- W2000829058 abstract "Objectives: The aim of this study is to determine the effectiveness of topical doxycycline used in the process of experimental myringosclerosis and tympanosclerosis. Study Design: A prospective experimental animal study. Methods: Experimental tympanosclerosis was accomplished in 25 healthy adult guinea pigs by inoculation with 2.5 × 107 colony-forming units of type-3 Streptococcus pneumoniae microorganisms followed by bilateral myringotomy. While the animals' right ears received a topical doxycycline treatment daily, their left ears were left untreated and used as controls. Otomicroscopic examination was carried out weekly and healing tympanic membranes were remyringotomized. After a 6-week follow-up, the temporal bones of 24 of 25 animals were removed and light-microscopy examination was done regarding tympanic membrane myringosclerosis and middle ear mucosal sclerosis. Results: Myringosclerosis was noticed to a lesser extent in the doxycycline-treated group when compared to the untreated control group. Light microscopy evaluation revealed a difference in the area and thickness of the sclerotic plaques of myringosclerosis of the tympanic membranes in the doxycycline-treated group and the control group, being significantly smaller and thinner in the treated group (P < .001, P < .04, respectively). Similarly, the area and thickness of the sclerotic plaques in the middle ear mucosa were significantly smaller and thinner in the doxycycline treated group (P < .001, P < .03). Conclusion: This study demonstrated that the potent matrix metallo-proteinase inhibitor doxycycline plays a preventive role in the development of experimentally induced tympanosclerosis." @default.
- W2000829058 created "2016-06-24" @default.
- W2000829058 creator A5029893011 @default.
- W2000829058 creator A5034996901 @default.
- W2000829058 creator A5036770833 @default.
- W2000829058 creator A5046050129 @default.
- W2000829058 creator A5053947293 @default.
- W2000829058 creator A5068209277 @default.
- W2000829058 creator A5090490068 @default.
- W2000829058 date "2008-06-01" @default.
- W2000829058 modified "2023-10-16" @default.
- W2000829058 title "The Effect of Topical Doxycycline in the Prevention of Experimental Tympanosclerosis" @default.
- W2000829058 cites W1552689030 @default.
- W2000829058 cites W1971825226 @default.
- W2000829058 cites W1974692755 @default.
- W2000829058 cites W1984002328 @default.
- W2000829058 cites W1985768272 @default.
- W2000829058 cites W1994913308 @default.
- W2000829058 cites W2002457445 @default.
- W2000829058 cites W2004200735 @default.
- W2000829058 cites W2008647167 @default.
- W2000829058 cites W2010543417 @default.
- W2000829058 cites W2011126362 @default.
- W2000829058 cites W2015701662 @default.
- W2000829058 cites W2017295248 @default.
- W2000829058 cites W2017788349 @default.
- W2000829058 cites W2018412409 @default.
- W2000829058 cites W2021299443 @default.
- W2000829058 cites W2026624415 @default.
- W2000829058 cites W2033655403 @default.
- W2000829058 cites W2040978516 @default.
- W2000829058 cites W2059234432 @default.
- W2000829058 cites W2060583405 @default.
- W2000829058 cites W2061427816 @default.
- W2000829058 cites W2072153975 @default.
- W2000829058 cites W2090390752 @default.
- W2000829058 cites W2093303753 @default.
- W2000829058 cites W2102842010 @default.
- W2000829058 cites W2108847816 @default.
- W2000829058 cites W2133997583 @default.
- W2000829058 cites W2144712422 @default.
- W2000829058 cites W2159614117 @default.
- W2000829058 cites W2165476491 @default.
- W2000829058 cites W229583690 @default.
- W2000829058 cites W2312188389 @default.
- W2000829058 cites W2315727797 @default.
- W2000829058 cites W2396086641 @default.
- W2000829058 cites W4240360948 @default.
- W2000829058 doi "https://doi.org/10.1097/mlg.0b013e31816770ba" @default.
- W2000829058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18388770" @default.
- W2000829058 hasPublicationYear "2008" @default.
- W2000829058 type Work @default.
- W2000829058 sameAs 2000829058 @default.
- W2000829058 citedByCount "13" @default.
- W2000829058 countsByYear W20008290582012 @default.
- W2000829058 countsByYear W20008290582013 @default.
- W2000829058 countsByYear W20008290582014 @default.
- W2000829058 countsByYear W20008290582015 @default.
- W2000829058 countsByYear W20008290582017 @default.
- W2000829058 countsByYear W20008290582018 @default.
- W2000829058 crossrefType "journal-article" @default.
- W2000829058 hasAuthorship W2000829058A5029893011 @default.
- W2000829058 hasAuthorship W2000829058A5034996901 @default.
- W2000829058 hasAuthorship W2000829058A5036770833 @default.
- W2000829058 hasAuthorship W2000829058A5046050129 @default.
- W2000829058 hasAuthorship W2000829058A5053947293 @default.
- W2000829058 hasAuthorship W2000829058A5068209277 @default.
- W2000829058 hasAuthorship W2000829058A5090490068 @default.
- W2000829058 hasConcept C141071460 @default.
- W2000829058 hasConcept C142724271 @default.
- W2000829058 hasConcept C203358219 @default.
- W2000829058 hasConcept C2776408402 @default.
- W2000829058 hasConcept C2777179404 @default.
- W2000829058 hasConcept C2777846895 @default.
- W2000829058 hasConcept C2777909021 @default.
- W2000829058 hasConcept C2778816616 @default.
- W2000829058 hasConcept C501593827 @default.
- W2000829058 hasConcept C71924100 @default.
- W2000829058 hasConcept C86803240 @default.
- W2000829058 hasConcept C89423630 @default.
- W2000829058 hasConceptScore W2000829058C141071460 @default.
- W2000829058 hasConceptScore W2000829058C142724271 @default.
- W2000829058 hasConceptScore W2000829058C203358219 @default.
- W2000829058 hasConceptScore W2000829058C2776408402 @default.
- W2000829058 hasConceptScore W2000829058C2777179404 @default.
- W2000829058 hasConceptScore W2000829058C2777846895 @default.
- W2000829058 hasConceptScore W2000829058C2777909021 @default.
- W2000829058 hasConceptScore W2000829058C2778816616 @default.
- W2000829058 hasConceptScore W2000829058C501593827 @default.
- W2000829058 hasConceptScore W2000829058C71924100 @default.
- W2000829058 hasConceptScore W2000829058C86803240 @default.
- W2000829058 hasConceptScore W2000829058C89423630 @default.
- W2000829058 hasIssue "6" @default.
- W2000829058 hasLocation W20008290581 @default.
- W2000829058 hasLocation W20008290582 @default.
- W2000829058 hasOpenAccess W2000829058 @default.
- W2000829058 hasPrimaryLocation W20008290581 @default.
- W2000829058 hasRelatedWork W1966109929 @default.