Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000830335> ?p ?o ?g. }
- W2000830335 endingPage "16937" @default.
- W2000830335 startingPage "16926" @default.
- W2000830335 abstract "Amyloid cascades leading to peptide β-sheet fibrils and plaques are central to many important diseases. Recently, intermediate assemblies of these cascades were identified as the toxic agents that interact with the cellular machinery. The relationship between the transformation from natively unstructured assembly to the β-sheet oligomers to disease is important in understanding disease onset and the development of therapeutic agents. Research on this early oligomeric region has largely been unsuccessful since traditional techniques measure only ensemble average oligomer properties. Here, ion mobility methods are utilized to deduce the modulation of peptide self-assembly pathways in the amyloid-β protein fragment Aβ(25–35) by two amyloid inhibitors (epigallocatechin gallate and scyllo-inositol) that are currently in clinical trials for Alzheimer’s Disease. We provide evidence that suppression of β-extended oligomers from the onset of the conversion into β-oligomer conformations is essential for effective attenuation of β-structured amyloid oligomeric species often associated with oligomer toxicity. Furthermore, we demonstrate the ease with which ion mobility spectrometry–mass spectrometry can guide the development of therapeutic agents and drug evaluation by providing molecular level insight into the amyloid formation process and its modulation by small molecule assembly modulators." @default.
- W2000830335 created "2016-06-24" @default.
- W2000830335 creator A5004382973 @default.
- W2000830335 creator A5014870553 @default.
- W2000830335 creator A5019825533 @default.
- W2000830335 creator A5031292318 @default.
- W2000830335 creator A5033847316 @default.
- W2000830335 creator A5034511172 @default.
- W2000830335 creator A5051727963 @default.
- W2000830335 creator A5071703870 @default.
- W2000830335 date "2013-11-01" @default.
- W2000830335 modified "2023-10-18" @default.
- W2000830335 title "Ion Mobility Spectrometry Reveals the Mechanism of Amyloid Formation of Aβ(25–35) and Its Modulation by Inhibitors at the Molecular Level: Epigallocatechin Gallate and <i>Scyllo</i>-inositol" @default.
- W2000830335 cites W1565076702 @default.
- W2000830335 cites W1935356375 @default.
- W2000830335 cites W1963780497 @default.
- W2000830335 cites W1965315991 @default.
- W2000830335 cites W1966721430 @default.
- W2000830335 cites W1969888070 @default.
- W2000830335 cites W1975561490 @default.
- W2000830335 cites W1976727092 @default.
- W2000830335 cites W1978617962 @default.
- W2000830335 cites W1980825524 @default.
- W2000830335 cites W1981545549 @default.
- W2000830335 cites W1982423863 @default.
- W2000830335 cites W1982653993 @default.
- W2000830335 cites W1983287291 @default.
- W2000830335 cites W1983668432 @default.
- W2000830335 cites W1986060177 @default.
- W2000830335 cites W1986267130 @default.
- W2000830335 cites W1989948422 @default.
- W2000830335 cites W1996645164 @default.
- W2000830335 cites W2001629328 @default.
- W2000830335 cites W2002900801 @default.
- W2000830335 cites W2004098528 @default.
- W2000830335 cites W2005279391 @default.
- W2000830335 cites W2007158408 @default.
- W2000830335 cites W2008342614 @default.
- W2000830335 cites W2009401461 @default.
- W2000830335 cites W2014140929 @default.
- W2000830335 cites W2014485936 @default.
- W2000830335 cites W2017291869 @default.
- W2000830335 cites W2020970511 @default.
- W2000830335 cites W2028064100 @default.
- W2000830335 cites W2032738986 @default.
- W2000830335 cites W2043833442 @default.
- W2000830335 cites W2045725844 @default.
- W2000830335 cites W2048604212 @default.
- W2000830335 cites W2048940684 @default.
- W2000830335 cites W2053168342 @default.
- W2000830335 cites W2053866466 @default.
- W2000830335 cites W2054781228 @default.
- W2000830335 cites W2060215277 @default.
- W2000830335 cites W2061187172 @default.
- W2000830335 cites W2061876586 @default.
- W2000830335 cites W2066024683 @default.
- W2000830335 cites W2069123478 @default.
- W2000830335 cites W2069429456 @default.
- W2000830335 cites W2069506919 @default.
- W2000830335 cites W2071610287 @default.
- W2000830335 cites W2071884490 @default.
- W2000830335 cites W2071982060 @default.
- W2000830335 cites W2074666700 @default.
- W2000830335 cites W2082317154 @default.
- W2000830335 cites W2084151521 @default.
- W2000830335 cites W2087256677 @default.
- W2000830335 cites W2089890181 @default.
- W2000830335 cites W2091354138 @default.
- W2000830335 cites W2092557507 @default.
- W2000830335 cites W2093645477 @default.
- W2000830335 cites W2093861673 @default.
- W2000830335 cites W2096410114 @default.
- W2000830335 cites W2106175044 @default.
- W2000830335 cites W2117537971 @default.
- W2000830335 cites W2119404766 @default.
- W2000830335 cites W2121963977 @default.
- W2000830335 cites W2125012012 @default.
- W2000830335 cites W2136363024 @default.
- W2000830335 cites W2139051378 @default.
- W2000830335 cites W2142038032 @default.
- W2000830335 cites W2143958500 @default.
- W2000830335 cites W2144481414 @default.
- W2000830335 cites W2147993766 @default.
- W2000830335 cites W2153171611 @default.
- W2000830335 cites W2161732570 @default.
- W2000830335 cites W2163210644 @default.
- W2000830335 cites W2165021720 @default.
- W2000830335 cites W2314128442 @default.
- W2000830335 cites W2335026087 @default.
- W2000830335 cites W99383509 @default.
- W2000830335 doi "https://doi.org/10.1021/ja406197f" @default.
- W2000830335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24131107" @default.
- W2000830335 hasPublicationYear "2013" @default.
- W2000830335 type Work @default.
- W2000830335 sameAs 2000830335 @default.
- W2000830335 citedByCount "82" @default.
- W2000830335 countsByYear W20008303352014 @default.
- W2000830335 countsByYear W20008303352015 @default.