FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000831208> ?p ?o ?g. }

• W2000831208 endingPage "228" @default.
• W2000831208 startingPage "219" @default.
• W2000831208 abstract "Dieldrin, an organochlorine pesticide, has been shown to be hepatocarcinogenic in mice but not rats. Phenobarbital, in contrast, induces hepatic tumors in both mice and rats. Previous studies have shown that acute dietary exposure of rats or mice to either dieldrin or phenobarbital produces several liver changes, including centrilobular hypertrophy, induction of hepatic cytochrome P450, and increased liver weight. The present study examined the subchronic effect of dieldrin (0.1, 1.0, 3.0, 10.0 mg dieldrin/kg diet) and phenobarbital (10, 50, 100, 500 mg phenobarbital/kg diet) on the induction of hepatic DNA synthesis and hepatocyte lethality in male B6C3F1 mice and male F344 rats. Eight-week-old animals were treated as above and evaluated for hepatic DNA synthesis after 7, 14, 21, 28, and 90 days of continual treatment to dieldrin or phenobarbital. Maximal induction of hepatic DNA synthesis in mice was seen at the 14-, 21-, and 28-day sampling times. In rats, no significant increase in hepatic DNA synthesis or hepatocyte lethality was observed at any dose of dieldrin investigated. Phenobarbital produced a significant increase in hepatic DNA synthesis in both rat and mouse liver following 7 days of treatment. The induction of DNA synthesis in rat liver was transient, with the labeling index returning to control levels by 14 days of treatment. In contrast, mice treated with phenobarbital showed a significant increase in hepatic DNA synthesis throughout the treatment. In both mice and rats, dieldrin and phenobarbital induced hepatic DNA synthesis selectively in the centrilobular region of the hepatic lobule. The lack of an increase in serum enzymes indicative of hepatic damage and the absence of liver histopathology in mice or rats fed dieldrin or phenobarbital indicate that the induction of DNA synthesis was not mediated by a cytolethal, compensatory hyperplastic response, suggesting a mitogenic mechanism. Therefore, the species-specific induction of hepatic DNA synthesis by either dieldrin or phenobarbital correlated with the previously observed species-specific induction of hepatic cancer by these two compounds." @default.
• W2000831208 created "2016-06-24" @default.
• W2000831208 creator A5020302175 @default.
• W2000831208 creator A5023743063 @default.
• W2000831208 creator A5043660511 @default.
• W2000831208 creator A5077350810 @default.
• W2000831208 creator A5091835887 @default.
• W2000831208 date "1996-02-01" @default.
• W2000831208 modified "2023-10-16" @default.
• W2000831208 title "Subchronic Effects of Dieldrin and Phenobarbital on Hepatic DNA Synthesis in Mice and Rats" @default.
• W2000831208 cites W1519731306 @default.
• W2000831208 cites W1971098129 @default.
• W2000831208 cites W1973041585 @default.
• W2000831208 cites W1975736498 @default.
• W2000831208 cites W1978253646 @default.
• W2000831208 cites W1984878066 @default.
• W2000831208 cites W1985724055 @default.
• W2000831208 cites W1994531473 @default.
• W2000831208 cites W1999497573 @default.
• W2000831208 cites W1999776550 @default.
• W2000831208 cites W2014179594 @default.
• W2000831208 cites W2016824196 @default.
• W2000831208 cites W2020312776 @default.
• W2000831208 cites W2020331748 @default.
• W2000831208 cites W2021494550 @default.
• W2000831208 cites W2034602546 @default.
• W2000831208 cites W2037970500 @default.
• W2000831208 cites W2038320378 @default.
• W2000831208 cites W2063727416 @default.
• W2000831208 cites W2072831880 @default.
• W2000831208 cites W2077259648 @default.
• W2000831208 cites W2094536764 @default.
• W2000831208 cites W2097066951 @default.
• W2000831208 cites W2121100406 @default.
• W2000831208 cites W2161836567 @default.
• W2000831208 cites W2335053978 @default.
• W2000831208 cites W2415231188 @default.
• W2000831208 doi "https://doi.org/10.1006/faat.1996.0025" @default.
• W2000831208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8742319" @default.
• W2000831208 hasPublicationYear "1996" @default.
• W2000831208 type Work @default.
• W2000831208 sameAs 2000831208 @default.
• W2000831208 citedByCount "56" @default.
• W2000831208 countsByYear W20008312082013 @default.
• W2000831208 countsByYear W20008312082014 @default.
• W2000831208 countsByYear W20008312082018 @default.
• W2000831208 countsByYear W20008312082020 @default.
• W2000831208 countsByYear W20008312082021 @default.
• W2000831208 countsByYear W20008312082023 @default.
• W2000831208 crossrefType "journal-article" @default.
• W2000831208 hasAuthorship W2000831208A5020302175 @default.
• W2000831208 hasAuthorship W2000831208A5023743063 @default.
• W2000831208 hasAuthorship W2000831208A5043660511 @default.
• W2000831208 hasAuthorship W2000831208A5077350810 @default.
• W2000831208 hasAuthorship W2000831208A5091835887 @default.
• W2000831208 hasConcept C126322002 @default.
• W2000831208 hasConcept C132154277 @default.
• W2000831208 hasConcept C134018914 @default.
• W2000831208 hasConcept C161176658 @default.
• W2000831208 hasConcept C181199279 @default.
• W2000831208 hasConcept C185592680 @default.
• W2000831208 hasConcept C202751555 @default.
• W2000831208 hasConcept C2776200302 @default.
• W2000831208 hasConcept C2776640376 @default.
• W2000831208 hasConcept C2778793413 @default.
• W2000831208 hasConcept C552990157 @default.
• W2000831208 hasConcept C55493867 @default.
• W2000831208 hasConcept C64241487 @default.
• W2000831208 hasConcept C6557445 @default.
• W2000831208 hasConcept C71924100 @default.
• W2000831208 hasConcept C86803240 @default.
• W2000831208 hasConceptScore W2000831208C126322002 @default.
• W2000831208 hasConceptScore W2000831208C132154277 @default.
• W2000831208 hasConceptScore W2000831208C134018914 @default.
• W2000831208 hasConceptScore W2000831208C161176658 @default.
• W2000831208 hasConceptScore W2000831208C181199279 @default.
• W2000831208 hasConceptScore W2000831208C185592680 @default.
• W2000831208 hasConceptScore W2000831208C202751555 @default.
• W2000831208 hasConceptScore W2000831208C2776200302 @default.
• W2000831208 hasConceptScore W2000831208C2776640376 @default.
• W2000831208 hasConceptScore W2000831208C2778793413 @default.
• W2000831208 hasConceptScore W2000831208C552990157 @default.
• W2000831208 hasConceptScore W2000831208C55493867 @default.
• W2000831208 hasConceptScore W2000831208C64241487 @default.
• W2000831208 hasConceptScore W2000831208C6557445 @default.
• W2000831208 hasConceptScore W2000831208C71924100 @default.
• W2000831208 hasConceptScore W2000831208C86803240 @default.
• W2000831208 hasIssue "2" @default.
• W2000831208 hasLocation W20008312081 @default.
• W2000831208 hasLocation W20008312082 @default.
• W2000831208 hasOpenAccess W2000831208 @default.
• W2000831208 hasPrimaryLocation W20008312081 @default.
• W2000831208 hasRelatedWork W1921357624 @default.
• W2000831208 hasRelatedWork W2000831208 @default.
• W2000831208 hasRelatedWork W2016984654 @default.
• W2000831208 hasRelatedWork W2020551456 @default.
• W2000831208 hasRelatedWork W2044988659 @default.
• W2000831208 hasRelatedWork W2094423915 @default.

• next