FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000831572> ?p ?o ?g. }

• W2000831572 endingPage "6037" @default.
• W2000831572 startingPage "6029" @default.
• W2000831572 abstract "Many kinds of natural sphingolipids and their analogs stimulate or inhibit a wide assortment of biochemical phenomena and enzymes. The puzzle considered here is: how can these lipids control so many different kinds of processes? In almost every study in which a structural comparison was made, an allylic alcohol moiety [-CH=CH-CH(OH)-] was found to be an essential feature of the sphingolipid. Many of those stimulations lead to cell death, emphasizing the importance of allylic sphingolipid structure in the design of chemotherapeutic agents. The proposal offered here is that these lipids function as coenzymes, in which the allylic moiety acts as an anion transferring agent, forming transient phosphate or acyl or peptidyl esters for the synthesis or hydrolysis of phosphoproteins, proteins, and phospholipids. Sphingolipids that inhibit these reactions may simply displace the active sphingolipids from their sites in the enzymes' active regions, or bind to the enzymes' allosteric region. This kind of competition could act as a major homeostatic control mechanism. Some of the allylic sphingolipids also generate reactive oxygen, possibly by oxidation of the allylic alcohol group. This explains the need to control redox-controlling metabolites in sphingolipid-controlled processes (e.g., glutathione). Many anticancer drugs that produce apoptosis in tumors possess an allylic alcohol residue, affect protein phosphorylation, and produce reactive oxygen species. They may be therapeutically useful because they control the action of sphingolipids as anion transfer agonists or inhibitors." @default.
• W2000831572 created "2016-06-24" @default.
• W2000831572 creator A5061360317 @default.
• W2000831572 date "2004-12-01" @default.
• W2000831572 modified "2023-09-25" @default.
• W2000831572 title "Sphingolipids as coenzymes in anion transfer and tumor death" @default.
• W2000831572 cites W1493983188 @default.
• W2000831572 cites W1542133938 @default.
• W2000831572 cites W1548829534 @default.
• W2000831572 cites W1549255782 @default.
• W2000831572 cites W1557346720 @default.
• W2000831572 cites W1571932777 @default.
• W2000831572 cites W16613574 @default.
• W2000831572 cites W1716249017 @default.
• W2000831572 cites W1761319647 @default.
• W2000831572 cites W1776217324 @default.
• W2000831572 cites W1964683047 @default.
• W2000831572 cites W1968091649 @default.
• W2000831572 cites W1971698720 @default.
• W2000831572 cites W1977884080 @default.
• W2000831572 cites W1987835768 @default.
• W2000831572 cites W1998249059 @default.
• W2000831572 cites W2003294283 @default.
• W2000831572 cites W2004999534 @default.
• W2000831572 cites W2011772344 @default.
• W2000831572 cites W2016234719 @default.
• W2000831572 cites W2016277586 @default.
• W2000831572 cites W2025036930 @default.
• W2000831572 cites W2029682546 @default.
• W2000831572 cites W2029923092 @default.
• W2000831572 cites W2034760363 @default.
• W2000831572 cites W2042392347 @default.
• W2000831572 cites W2043830456 @default.
• W2000831572 cites W2045380458 @default.
• W2000831572 cites W2064240314 @default.
• W2000831572 cites W2065399078 @default.
• W2000831572 cites W2065950908 @default.
• W2000831572 cites W2072861616 @default.
• W2000831572 cites W2081504673 @default.
• W2000831572 cites W2086025404 @default.
• W2000831572 cites W2089295555 @default.
• W2000831572 cites W2111452373 @default.
• W2000831572 cites W2126167700 @default.
• W2000831572 cites W2129889115 @default.
• W2000831572 cites W2132805096 @default.
• W2000831572 cites W2135425001 @default.
• W2000831572 cites W2138728266 @default.
• W2000831572 cites W2169082359 @default.
• W2000831572 doi "https://doi.org/10.1016/j.bmc.2004.08.023" @default.
• W2000831572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15519148" @default.
• W2000831572 hasPublicationYear "2004" @default.
• W2000831572 type Work @default.
• W2000831572 sameAs 2000831572 @default.
• W2000831572 citedByCount "17" @default.
• W2000831572 countsByYear W20008315722013 @default.
• W2000831572 countsByYear W20008315722014 @default.
• W2000831572 countsByYear W20008315722016 @default.
• W2000831572 countsByYear W20008315722017 @default.
• W2000831572 countsByYear W20008315722018 @default.
• W2000831572 crossrefType "journal-article" @default.
• W2000831572 hasAuthorship W2000831572A5061360317 @default.
• W2000831572 hasConcept C120095180 @default.
• W2000831572 hasConcept C161790260 @default.
• W2000831572 hasConcept C166342909 @default.
• W2000831572 hasConcept C181199279 @default.
• W2000831572 hasConcept C185592680 @default.
• W2000831572 hasConcept C197957613 @default.
• W2000831572 hasConcept C2776568683 @default.
• W2000831572 hasConcept C55493867 @default.
• W2000831572 hasConcept C61705674 @default.
• W2000831572 hasConcept C71240020 @default.
• W2000831572 hasConceptScore W2000831572C120095180 @default.
• W2000831572 hasConceptScore W2000831572C161790260 @default.
• W2000831572 hasConceptScore W2000831572C166342909 @default.
• W2000831572 hasConceptScore W2000831572C181199279 @default.
• W2000831572 hasConceptScore W2000831572C185592680 @default.
• W2000831572 hasConceptScore W2000831572C197957613 @default.
• W2000831572 hasConceptScore W2000831572C2776568683 @default.
• W2000831572 hasConceptScore W2000831572C55493867 @default.
• W2000831572 hasConceptScore W2000831572C61705674 @default.
• W2000831572 hasConceptScore W2000831572C71240020 @default.
• W2000831572 hasIssue "23" @default.
• W2000831572 hasLocation W20008315721 @default.
• W2000831572 hasLocation W20008315722 @default.
• W2000831572 hasOpenAccess W2000831572 @default.
• W2000831572 hasPrimaryLocation W20008315721 @default.
• W2000831572 hasRelatedWork W1164537646 @default.
• W2000831572 hasRelatedWork W1560866290 @default.
• W2000831572 hasRelatedWork W1628841485 @default.
• W2000831572 hasRelatedWork W169735115 @default.
• W2000831572 hasRelatedWork W1995545479 @default.
• W2000831572 hasRelatedWork W2002189973 @default.
• W2000831572 hasRelatedWork W2076105148 @default.
• W2000831572 hasRelatedWork W2080203695 @default.
• W2000831572 hasRelatedWork W2084240653 @default.
• W2000831572 hasRelatedWork W2170874906 @default.
• W2000831572 hasVolume "12" @default.
• W2000831572 isParatext "false" @default.

• next