Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000832385> ?p ?o ?g. }
- W2000832385 endingPage "1254" @default.
- W2000832385 startingPage "1245" @default.
- W2000832385 abstract "Fibroblast growth factor 2 (FGF2) consists of multiple protein isoforms (low [LMW] and high molecular weight [HMW]), which are localized to different cellular compartments, indicating unique biological activity. We previously showed that the LMW isoform is important in protecting the heart from myocardial dysfunction associated with ischemia–reperfusion (I/R) injury, but the roles of the HMW isoforms remain unknown. To elucidate the role of HMW isoforms in I/R and cardioprotection, hearts from novel mouse models, in which the murine FGF2 HMWs are knocked out (HMWKO) or the human FGF2 24 kDa HMW isoform is overexpressed (HMW Tg) and their wildtype (Wt) or non-transgenic (NTg) cohorts were subjected to an ex vivo work-performing heart model of I/R. There was a significant improvement in post-ischemic recovery of cardiac function in HMWKO hearts (76±5%, p<0.05) compared to Wt hearts (55±5%), with a corresponding decrease in HMW Tg function (line 20: 38±6% and line 28: 33±4%, p<0.05) compared to non-transgenic hearts (68±9%). FGF2 LMW isoform was secreted from Wt and HMWKO hearts during I/R, and a FGF receptor (FGFR) inhibitor, PD173074 caused a decrease in cardiac function when administered in I/R in Wt and FGF2 HMWKO hearts (p<0.05), indicating that FGFR is involved in FGF2 LMW isoform's biological effect in ischemia–reperfusion injury. Moreover, overexpression of HMW isoform reduced FGFR1 phosphorylation/activation with no further decrease in the phosphorylation state in the presence of the FGFR inhibitor. Overall, our data indicate that HMW isoforms have a detrimental role in the development of post-ischemic myocardial dysfunction." @default.
- W2000832385 created "2016-06-24" @default.
- W2000832385 creator A5020986129 @default.
- W2000832385 creator A5026429897 @default.
- W2000832385 creator A5042026654 @default.
- W2000832385 creator A5050455584 @default.
- W2000832385 creator A5058430642 @default.
- W2000832385 creator A5058751203 @default.
- W2000832385 creator A5064484538 @default.
- W2000832385 date "2010-06-01" @default.
- W2000832385 modified "2023-10-17" @default.
- W2000832385 title "The influence of FGF2 high molecular weight (HMW) isoforms in the development of cardiac ischemia–reperfusion injury" @default.
- W2000832385 cites W1608598729 @default.
- W2000832385 cites W1976368073 @default.
- W2000832385 cites W1983052217 @default.
- W2000832385 cites W1991117742 @default.
- W2000832385 cites W1992506240 @default.
- W2000832385 cites W1992534738 @default.
- W2000832385 cites W2008747057 @default.
- W2000832385 cites W2010531937 @default.
- W2000832385 cites W2013931793 @default.
- W2000832385 cites W2020923674 @default.
- W2000832385 cites W2029707326 @default.
- W2000832385 cites W2050090499 @default.
- W2000832385 cites W2054224650 @default.
- W2000832385 cites W2054264765 @default.
- W2000832385 cites W2070524992 @default.
- W2000832385 cites W2077486338 @default.
- W2000832385 cites W2079962678 @default.
- W2000832385 cites W2084062003 @default.
- W2000832385 cites W2084426569 @default.
- W2000832385 cites W2085717449 @default.
- W2000832385 cites W2089726534 @default.
- W2000832385 cites W2091498699 @default.
- W2000832385 cites W2092078490 @default.
- W2000832385 cites W2096950509 @default.
- W2000832385 cites W2104833083 @default.
- W2000832385 cites W2106279829 @default.
- W2000832385 cites W2106727226 @default.
- W2000832385 cites W2112817429 @default.
- W2000832385 cites W2119537724 @default.
- W2000832385 cites W2138178479 @default.
- W2000832385 cites W2139289160 @default.
- W2000832385 cites W2140388309 @default.
- W2000832385 cites W2141759179 @default.
- W2000832385 cites W2148634186 @default.
- W2000832385 cites W2162831628 @default.
- W2000832385 cites W2169904378 @default.
- W2000832385 cites W2216737807 @default.
- W2000832385 cites W2323702574 @default.
- W2000832385 cites W3146298412 @default.
- W2000832385 cites W4249132419 @default.
- W2000832385 doi "https://doi.org/10.1016/j.yjmcc.2010.01.014" @default.
- W2000832385 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3842106" @default.
- W2000832385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20116383" @default.
- W2000832385 hasPublicationYear "2010" @default.
- W2000832385 type Work @default.
- W2000832385 sameAs 2000832385 @default.
- W2000832385 citedByCount "26" @default.
- W2000832385 countsByYear W20008323852012 @default.
- W2000832385 countsByYear W20008323852013 @default.
- W2000832385 countsByYear W20008323852014 @default.
- W2000832385 countsByYear W20008323852015 @default.
- W2000832385 countsByYear W20008323852016 @default.
- W2000832385 countsByYear W20008323852017 @default.
- W2000832385 countsByYear W20008323852018 @default.
- W2000832385 countsByYear W20008323852019 @default.
- W2000832385 countsByYear W20008323852020 @default.
- W2000832385 countsByYear W20008323852021 @default.
- W2000832385 countsByYear W20008323852022 @default.
- W2000832385 countsByYear W20008323852023 @default.
- W2000832385 crossrefType "journal-article" @default.
- W2000832385 hasAuthorship W2000832385A5020986129 @default.
- W2000832385 hasAuthorship W2000832385A5026429897 @default.
- W2000832385 hasAuthorship W2000832385A5042026654 @default.
- W2000832385 hasAuthorship W2000832385A5050455584 @default.
- W2000832385 hasAuthorship W2000832385A5058430642 @default.
- W2000832385 hasAuthorship W2000832385A5058751203 @default.
- W2000832385 hasAuthorship W2000832385A5064484538 @default.
- W2000832385 hasBestOaLocation W20008323852 @default.
- W2000832385 hasConcept C102230213 @default.
- W2000832385 hasConcept C104317684 @default.
- W2000832385 hasConcept C111566952 @default.
- W2000832385 hasConcept C11960822 @default.
- W2000832385 hasConcept C126322002 @default.
- W2000832385 hasConcept C134018914 @default.
- W2000832385 hasConcept C141035611 @default.
- W2000832385 hasConcept C170493617 @default.
- W2000832385 hasConcept C185592680 @default.
- W2000832385 hasConcept C202751555 @default.
- W2000832385 hasConcept C26291073 @default.
- W2000832385 hasConcept C2778198053 @default.
- W2000832385 hasConcept C2779676291 @default.
- W2000832385 hasConcept C2780114680 @default.
- W2000832385 hasConcept C53345823 @default.
- W2000832385 hasConcept C541997718 @default.
- W2000832385 hasConcept C55493867 @default.
- W2000832385 hasConcept C71924100 @default.