FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000832392> ?p ?o ?g. }

• W2000832392 abstract "Aligned nanofibrous scaffolds hold tremendous potential for the engineering of dense connective tissues. These biomimetic micropatterns direct organized cell-mediated matrix deposition and can be tuned to possess nonlinear and anisotropic mechanical properties. For these scaffolds to function in vivo, however, they must either recapitulate the full dynamic mechanical range of the native tissue upon implantation or must foster cell infiltration and matrix deposition so as to enable construct maturation to meet these criteria. In our recent studies, we noted that cell infiltration into dense aligned structures is limited but could be expedited via the inclusion of a distinct rapidly eroding sacrificial component. In the present study, we sought to further the fabrication of dynamic nanofibrous constructs by combining multiple-fiber populations, each with distinct mechanical characteristics, into a single composite nanofibrous scaffold. Toward this goal, we developed a novel method for the generation of aligned electrospun composites containing rapidly eroding (PEO), moderately degradable (PLGA and PCL/PLGA), and slowly degrading (PCL) fiber populations. We evaluated the mechanical properties of these composites upon formation and with degradation in a physiologic environment. Furthermore, we employed a hyperelastic constrained-mixture model to capture the nonlinear and time-dependent properties of these scaffolds when formed as single-fiber populations or in multipolymer composites. After validating this model, we demonstrated that by carefully selecting fiber populations with differing mechanical properties and altering the relative fraction of each, a wide range of mechanical properties (and degradation characteristics) can be achieved. This advance allows for the rational design of nanofibrous scaffolds to match native tissue properties and will significantly enhance our ability to fabricate replacements for load-bearing tissues of the musculoskeletal system." @default.
• W2000832392 created "2016-06-24" @default.
• W2000832392 creator A5009243966 @default.
• W2000832392 creator A5015297374 @default.
• W2000832392 creator A5018983636 @default.
• W2000832392 creator A5026268740 @default.
• W2000832392 creator A5069952936 @default.
• W2000832392 date "2009-09-14" @default.
• W2000832392 modified "2023-09-30" @default.
• W2000832392 title "Fabrication and Modeling of Dynamic Multipolymer Nanofibrous Scaffolds" @default.
• W2000832392 cites W1982549006 @default.
• W2000832392 cites W1985090581 @default.
• W2000832392 cites W1993895799 @default.
• W2000832392 cites W1994425186 @default.
• W2000832392 cites W1996114090 @default.
• W2000832392 cites W1997617677 @default.
• W2000832392 cites W1998642283 @default.
• W2000832392 cites W1999813650 @default.
• W2000832392 cites W2003901870 @default.
• W2000832392 cites W2005090263 @default.
• W2000832392 cites W2010210350 @default.
• W2000832392 cites W2011590928 @default.
• W2000832392 cites W2019383346 @default.
• W2000832392 cites W2019575274 @default.
• W2000832392 cites W2027403642 @default.
• W2000832392 cites W2030667189 @default.
• W2000832392 cites W2034174652 @default.
• W2000832392 cites W2043272676 @default.
• W2000832392 cites W2043799833 @default.
• W2000832392 cites W2045223094 @default.
• W2000832392 cites W2055630021 @default.
• W2000832392 cites W2059139436 @default.
• W2000832392 cites W2060696701 @default.
• W2000832392 cites W2066678708 @default.
• W2000832392 cites W2069025518 @default.
• W2000832392 cites W2070031476 @default.
• W2000832392 cites W2080249125 @default.
• W2000832392 cites W2084332178 @default.
• W2000832392 cites W2097922419 @default.
• W2000832392 cites W2100832955 @default.
• W2000832392 cites W2122239005 @default.
• W2000832392 cites W2134826917 @default.
• W2000832392 cites W2135003417 @default.
• W2000832392 cites W2143691028 @default.
• W2000832392 cites W2150295226 @default.
• W2000832392 cites W2152524298 @default.
• W2000832392 cites W2156951480 @default.
• W2000832392 cites W2163545688 @default.
• W2000832392 cites W2334597378 @default.
• W2000832392 doi "https://doi.org/10.1115/1.3192140" @default.
• W2000832392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2830731" @default.
• W2000832392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19831482" @default.
• W2000832392 hasPublicationYear "2009" @default.
• W2000832392 type Work @default.
• W2000832392 sameAs 2000832392 @default.
• W2000832392 citedByCount "79" @default.
• W2000832392 countsByYear W20008323922012 @default.
• W2000832392 countsByYear W20008323922013 @default.
• W2000832392 countsByYear W20008323922014 @default.
• W2000832392 countsByYear W20008323922015 @default.
• W2000832392 countsByYear W20008323922016 @default.
• W2000832392 countsByYear W20008323922017 @default.
• W2000832392 countsByYear W20008323922018 @default.
• W2000832392 countsByYear W20008323922019 @default.
• W2000832392 countsByYear W20008323922020 @default.
• W2000832392 countsByYear W20008323922021 @default.
• W2000832392 countsByYear W20008323922022 @default.
• W2000832392 countsByYear W20008323922023 @default.
• W2000832392 crossrefType "journal-article" @default.
• W2000832392 hasAuthorship W2000832392A5009243966 @default.
• W2000832392 hasAuthorship W2000832392A5015297374 @default.
• W2000832392 hasAuthorship W2000832392A5018983636 @default.
• W2000832392 hasAuthorship W2000832392A5026268740 @default.
• W2000832392 hasAuthorship W2000832392A5069952936 @default.
• W2000832392 hasBestOaLocation W20008323922 @default.
• W2000832392 hasConcept C104779481 @default.
• W2000832392 hasConcept C127413603 @default.
• W2000832392 hasConcept C135628077 @default.
• W2000832392 hasConcept C136229726 @default.
• W2000832392 hasConcept C136525101 @default.
• W2000832392 hasConcept C142724271 @default.
• W2000832392 hasConcept C144796933 @default.
• W2000832392 hasConcept C147370603 @default.
• W2000832392 hasConcept C159985019 @default.
• W2000832392 hasConcept C171250308 @default.
• W2000832392 hasConcept C192562407 @default.
• W2000832392 hasConcept C204787440 @default.
• W2000832392 hasConcept C49892992 @default.
• W2000832392 hasConcept C519885992 @default.
• W2000832392 hasConcept C521977710 @default.
• W2000832392 hasConcept C66938386 @default.
• W2000832392 hasConcept C71924100 @default.
• W2000832392 hasConcept C89429830 @default.
• W2000832392 hasConceptScore W2000832392C104779481 @default.
• W2000832392 hasConceptScore W2000832392C127413603 @default.
• W2000832392 hasConceptScore W2000832392C135628077 @default.
• W2000832392 hasConceptScore W2000832392C136229726 @default.
• W2000832392 hasConceptScore W2000832392C136525101 @default.
• W2000832392 hasConceptScore W2000832392C142724271 @default.
• W2000832392 hasConceptScore W2000832392C144796933 @default.

• next