FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000832849> ?p ?o ?g. }

• W2000832849 endingPage "98" @default.
• W2000832849 startingPage "85" @default.
• W2000832849 abstract "The activity of the enzyme lecithin:cholesterol acyltransferase (LCAT) and the properties of its lipoprotein substrates have been investigated in 6- and 19-month-old Fischer-344 rats. These studies were carried out to determine the nature of the relationship between the observed hypercholesterolemia and the age-related decrease in the fractional rate of lipoprotein cholesterol esterification. The distribution of LCAT activity of plasma fractions was determined following gel chromatography and ultracentrifugation respectively. LCAT activity was found to be associated with the high density lipoprotein (HDL) fraction when rat plasma was passed through a Bio-Gel A-5 M column. Upon density gradient ultracentrifugation for 24 h it was found associated with HDL fraction; d = 1.125-1.21 g/ml. However, following prolonged ultracentrifugation (40 h), the majority of the LCAT activity was displaced into the lipoprotein-free infranatant (d greater than 1.225 g/ml). The dissociation of LCAT from its complex with HDL occurred to a smaller extent in aged rat plasma than in young rat plasma. Substrate specificity studies indicated that HDL was a considerably better substrate for LCAT than very low density lipoproteins (VLDL) in both young and aged rats. In addition, HDL from young rats was a better substrate for LCAT than the HDL from aged rats. Incubation experiments followed by the isolation of lipoproteins and the subsequent analyses of their cholesterol contents revealed that the age-related hypercholesterolemia was mainly due to an increase in the cholesterol carried by lipoprotein fractions d = 1.025 -1.07 g/ml (LDL + HDL1). These and other low density lipoproteins (d less than 1.025 g/ml) were poor substrates for LCAT. However, these lipoproteins could provide free cholesterol for esterification by first transferring it to HDL (d = 1.07-1.21). The HDL isolated from the plasma of aged rats was enriched with apolipoprotein (apo) E and these lipoprotein particles were found to be inferior substrates for LCAT. These data suggest that the decreased fractional rate of esterification observed in aged rats is due to the slower utilization of the HDL lipid substrate pool by the enzyme LCAT as a result of the accumulation of unfavorable substrates (compositionally altered HDL particles) for the LCAT reaction." @default.
• W2000832849 created "2016-06-24" @default.
• W2000832849 creator A5057383019 @default.
• W2000832849 creator A5059396674 @default.
• W2000832849 creator A5067970030 @default.
• W2000832849 date "1991-11-01" @default.
• W2000832849 modified "2023-09-27" @default.
• W2000832849 title "Age related changes in the lipoprotein substrates for the esterification of plasma cholesterol in rats" @default.
• W2000832849 cites W1106257837 @default.
• W2000832849 cites W1494227542 @default.
• W2000832849 cites W1504314697 @default.
• W2000832849 cites W1525818079 @default.
• W2000832849 cites W1528518879 @default.
• W2000832849 cites W1548493771 @default.
• W2000832849 cites W1772691120 @default.
• W2000832849 cites W1878775584 @default.
• W2000832849 cites W1946263363 @default.
• W2000832849 cites W1975477958 @default.
• W2000832849 cites W1977265234 @default.
• W2000832849 cites W1985765529 @default.
• W2000832849 cites W2017116639 @default.
• W2000832849 cites W2017640755 @default.
• W2000832849 cites W2028271503 @default.
• W2000832849 cites W2061068169 @default.
• W2000832849 cites W2063835144 @default.
• W2000832849 cites W2065912337 @default.
• W2000832849 cites W2065923464 @default.
• W2000832849 cites W2079153945 @default.
• W2000832849 cites W2080602731 @default.
• W2000832849 cites W2088615805 @default.
• W2000832849 cites W2100837269 @default.
• W2000832849 cites W2113006405 @default.
• W2000832849 cites W2150841230 @default.
• W2000832849 cites W2170247904 @default.
• W2000832849 cites W2283252701 @default.
• W2000832849 cites W2286693575 @default.
• W2000832849 cites W2322505715 @default.
• W2000832849 cites W2340499990 @default.
• W2000832849 cites W2398093727 @default.
• W2000832849 cites W2413261843 @default.
• W2000832849 doi "https://doi.org/10.1016/0047-6374(91)90008-n" @default.
• W2000832849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1779703" @default.
• W2000832849 hasPublicationYear "1991" @default.
• W2000832849 type Work @default.
• W2000832849 sameAs 2000832849 @default.
• W2000832849 citedByCount "6" @default.
• W2000832849 crossrefType "journal-article" @default.
• W2000832849 hasAuthorship W2000832849A5057383019 @default.
• W2000832849 hasAuthorship W2000832849A5059396674 @default.
• W2000832849 hasAuthorship W2000832849A5067970030 @default.
• W2000832849 hasConcept C110459506 @default.
• W2000832849 hasConcept C126322002 @default.
• W2000832849 hasConcept C134018914 @default.
• W2000832849 hasConcept C185592680 @default.
• W2000832849 hasConcept C2776448209 @default.
• W2000832849 hasConcept C2778163477 @default.
• W2000832849 hasConcept C2779564620 @default.
• W2000832849 hasConcept C2780072125 @default.
• W2000832849 hasConcept C2780541478 @default.
• W2000832849 hasConcept C37002583 @default.
• W2000832849 hasConcept C43617362 @default.
• W2000832849 hasConcept C54689828 @default.
• W2000832849 hasConcept C55493867 @default.
• W2000832849 hasConcept C71924100 @default.
• W2000832849 hasConcept C8004288 @default.
• W2000832849 hasConcept C8243546 @default.
• W2000832849 hasConcept C86803240 @default.
• W2000832849 hasConceptScore W2000832849C110459506 @default.
• W2000832849 hasConceptScore W2000832849C126322002 @default.
• W2000832849 hasConceptScore W2000832849C134018914 @default.
• W2000832849 hasConceptScore W2000832849C185592680 @default.
• W2000832849 hasConceptScore W2000832849C2776448209 @default.
• W2000832849 hasConceptScore W2000832849C2778163477 @default.
• W2000832849 hasConceptScore W2000832849C2779564620 @default.
• W2000832849 hasConceptScore W2000832849C2780072125 @default.
• W2000832849 hasConceptScore W2000832849C2780541478 @default.
• W2000832849 hasConceptScore W2000832849C37002583 @default.
• W2000832849 hasConceptScore W2000832849C43617362 @default.
• W2000832849 hasConceptScore W2000832849C54689828 @default.
• W2000832849 hasConceptScore W2000832849C55493867 @default.
• W2000832849 hasConceptScore W2000832849C71924100 @default.
• W2000832849 hasConceptScore W2000832849C8004288 @default.
• W2000832849 hasConceptScore W2000832849C8243546 @default.
• W2000832849 hasConceptScore W2000832849C86803240 @default.
• W2000832849 hasIssue "1" @default.
• W2000832849 hasLocation W20008328491 @default.
• W2000832849 hasLocation W20008328492 @default.
• W2000832849 hasOpenAccess W2000832849 @default.
• W2000832849 hasPrimaryLocation W20008328491 @default.
• W2000832849 hasRelatedWork W1157586721 @default.
• W2000832849 hasRelatedWork W1494227542 @default.
• W2000832849 hasRelatedWork W1979722563 @default.
• W2000832849 hasRelatedWork W1982829879 @default.
• W2000832849 hasRelatedWork W2000832849 @default.
• W2000832849 hasRelatedWork W2020232163 @default.
• W2000832849 hasRelatedWork W2074878534 @default.
• W2000832849 hasRelatedWork W2122454094 @default.
• W2000832849 hasRelatedWork W2149325223 @default.

• next