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- W2000835250 abstract "Background: Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), produced by endotoxin-activated Kupffer cells, play a key role in the pathogenesis of alcoholic liver cirrhosis (ALC). Alleles TNFA –238A, IL1B –31T and variant IL1RN*2 of repeat polymorphism in the gene encoding the IL-1 receptor antagonist increase production of TNF-α and IL-1β, respectively. Alleles CD14 –159T, TLR4 c.896G and TLR4 c.1196T modify activation of Kupffer cells by endotoxin. We confirmed the published associations between these common variants and genetic predisposition to ALC by means of a large case-control association study conducted on two Central European populations." @default.
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- W2000835250 date "2009-01-01" @default.
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- W2000835250 title "Do common genetic variants in endotoxin signaling pathway contribute to predisposition to alcoholic liver cirrhosis?" @default.
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- W2000835250 doi "https://doi.org/10.1515/cclm.2009.112" @default.
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