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- W2000836686 abstract "Letters15 June 1994Prostate Cancer ScreeningFrederick J. Meyers, MD and Paul H. Gumerlock, PhDFrederick J. Meyers, MDUniversity of California, Davis, Cancer Center; Sacramento, CA 95817Search for more papers by this author and Paul H. Gumerlock, PhDUniversity of California, Davis, Cancer Center; Sacramento, CA 95817Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-12-199406150-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The insightful article by Kramer and colleagues [1] and the accompanying editorial by Walsh [2] fail to recognize that the explanation for the success or failure of screening programs for cancer is its exquisite biology. The lessons from other malignancies can be translated to the investigation of prostatic carcinoma. Kramer and colleagues recognize that a cancer of one specific type is not monolithic but diverse in its biological behavior. The ubiquitous term “aggressive” should be replaced by more precise language about the potential for metastasis. The statistical term “lead time bias” would be converted into an understandable ...References1. Kramer BS, Brown ML, Prorok PC, Potosky AL. Prostate cancer screening: what we know and what we need to know. Ann Intern Med. 1993; 119:914-23. Google Scholar2. Walsh PC. Using prostate-specific antigen to diagnose prostate cancer: sailing in uncharted waters (Editorial). Ann Intern Med. 1993; 119:948-9. Google Scholar3. Sporn MB. Chemoprevention of cancer. Lancet. 1993; 342:1211-3. Google Scholar4. Aznavoorian S, Murphy AN, Stetler-Stevenson WG, Liotta LA. Molecular aspects of tumor cell invasion and metastasis. Cancer. 1993; 71:1368-83. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of California, Davis, Cancer Center; Sacramento, CA 95817 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byShould medicare provide reimbursement for prostate-specific antigen testing for early detection of prostate cancer? part I: Framing the debate 15 June 1994Volume 120, Issue 12Page: 1052-1053KeywordsCancer geneticsCancer screeningCarcinogenesisCellsChemopreventionDeath ratesLesionsMolecular biologyProstate cancerRandomized trials Issue Published: 15 June 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ..." @default.
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