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• W2000839377 startingPage "8292" @default.
• W2000839377 abstract "KL 4 is a 21-residue peptide employed as a functional mimic of lung surfactant protein B, which successfully lowers surface tension in the alveoli. A mechanistic understanding of how KL 4 affects lipid properties has proven elusive as the secondary structure of KL 4 in lipid preparations has not been determined at high resolution. The sequence of KL 4 is based on the C-terminus of SP-B, a naturally occurring helical protein that binds to lipid interfaces. The spacing of the lysine residues in KL 4 precludes the formation of a canonical amphipathic alpha-helix; qualitative measurements using Raman, CD, and FTIR spectroscopies have given conflicting results as to the secondary structure of the peptide as well as its orientation in the lipid environment. Here, we present a structural model of KL 4 bound to lipid bilayers based on solid state NMR data. Double-quantum correlation experiments employing (13)C-enriched peptides were used to quantitatively determine the backbone torsion angles in KL 4 at several positions. These measurements, coupled with CD experiments, verify the helical nature of KL 4 when bound to lipids, with (phi, psi) angles that differ substantially from common values for alpha-helices of (-60, -45). The average torsion angles found for KL 4 bound to POPC:POPG lipid vesicles are (-105, -30); this deviation from ideal alpha-helical structure allows KL 4 to form an amphipathic helix at the lipid interface." @default.
• W2000839377 created "2016-06-24" @default.
• W2000839377 creator A5021098087 @default.
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• W2000839377 creator A5072532310 @default.
• W2000839377 creator A5072747238 @default.
• W2000839377 date "2008-07-18" @default.
• W2000839377 modified "2023-09-27" @default.
• W2000839377 title "The Helical Structure of Surfactant Peptide KL₄ When Bound to POPC: POPG Lipid Vesicles" @default.
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• W2000839377 doi "https://doi.org/10.1021/bi702551c" @default.
• W2000839377 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2629594" @default.
• W2000839377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18636713" @default.
• W2000839377 hasPublicationYear "2008" @default.
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