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- W2000839903 abstract "Abstract An early clinical symptom in scleroderma patients is Raynaud's phenomenon. Later cutaneous manifestations of the disease include oedematous swelling in the extremities and in more extreme cases often very painful, refractory acral necroses. We report on a 56‐year‐old female patient who participated in a prospective, double‐blind, multicentre comparative pilot study because of her severe Raynaud symptoms, with dystrophic skin lesions on both hands. The goal of the study was to evaluate the efficacy and safety of prostaglandin E 1 ethyl ester in a transdermal drug delivery system compared with placebo in patients with secondary Raynaud's phenomenon associated with systemic scleroderma or mixed connective tissue disease. After 2 weeks of verum treatment the patient experienced a marked improvement of Raynaud's attacks, with increased capillary flow velocity, reduced blood stasis and clinical healing of the acral trophic lesions. For this patient the transdermal application of prostaglandin E 1 ethyl ester in the form of a medicated patch proved to be a simple and effective therapy for the acral trophic skin lesions associated with systemic scleroderma." @default.
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- W2000839903 date "2002-09-01" @default.
- W2000839903 modified "2023-10-18" @default.
- W2000839903 title "Transdermal application of prostaglandin E1 ethyl ester for the treatment of trophic acral skin lesions in a patient with systemic scleroderma" @default.
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- W2000839903 doi "https://doi.org/10.1046/j.1468-3083.2002.00433.x" @default.
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