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- W2000841769 endingPage "25000" @default.
- W2000841769 startingPage "24992" @default.
- W2000841769 abstract "After the original identification of thyroid transcription factor 1 (TTF-1 or NKX2-1) biochemical activity as a transcriptional regulator of thyroglobulin in 1989, the bulk of the ensuing research has concentrated on elucidating the roles of NKX2-1 in the development of lung and thyroid tissues. Motivated by its specific expression pattern, pathologists adopted the NKX2-1 immunoreactivity to distinguish pulmonary from nonpulmonary nonthyroid adenocarcinomas. Interestingly, the concept of NKX2-1 as an active participant in lung tumorigenesis did not take hold until 2007. This minireview contrasts the recent advancements of NKX2-1-related observations primarily in the realm of pulmonary malignancies. After the original identification of thyroid transcription factor 1 (TTF-1 or NKX2-1) biochemical activity as a transcriptional regulator of thyroglobulin in 1989, the bulk of the ensuing research has concentrated on elucidating the roles of NKX2-1 in the development of lung and thyroid tissues. Motivated by its specific expression pattern, pathologists adopted the NKX2-1 immunoreactivity to distinguish pulmonary from nonpulmonary nonthyroid adenocarcinomas. Interestingly, the concept of NKX2-1 as an active participant in lung tumorigenesis did not take hold until 2007. This minireview contrasts the recent advancements of NKX2-1-related observations primarily in the realm of pulmonary malignancies." @default.
- W2000841769 created "2016-06-24" @default.
- W2000841769 creator A5037201369 @default.
- W2000841769 date "2013-08-01" @default.
- W2000841769 modified "2023-10-06" @default.
- W2000841769 title "The Complexity of Thyroid Transcription Factor 1 with Both Pro- and Anti-oncogenic Activities" @default.
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- W2000841769 doi "https://doi.org/10.1074/jbc.r113.491647" @default.