FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000842113> ?p ?o ?g. }

• W2000842113 abstract "Abstract Background NLRPs (Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing Proteins) are members of NLR (Nod-like receptors) protein family. Recent researches have shown that NLRP genes play important roles in both mammalian innate immune system and reproductive system. Several of NLRP genes were shown to be specifically expressed in the oocyte in mammals. The aim of the present work was to study how these genes evolved and diverged after their duplication, as well as whether natural selection played a role during their evolution. Results By using in silico methods, we have evaluated the evolution and functional divergence of NLRP genes, in particular of mouse reproduction-related Nlrp genes. We found that (1) major NLRP genes have been duplicated before the divergence of mammals, with certain lineage-specific duplications in primates ( NLRP7 and 11 ) and in rodents ( Nlrp1 , 4 and 9 duplicates); (2) tandem duplication events gave rise to a mammalian reproduction-related NLRP cluster including NLRP2 , 4 , 5 , 7 , 8 , 9 , 11 , 13 and 14 genes; (3) the function of mammalian oocyte-specific NLRP genes ( NLRP4 , 5 , 9 and 14 ) might have diverged during gene evolution; (4) recent segmental duplications concerning Nlrp4 copies and vomeronasal 1 receptor encoding genes ( V1r ) have been undertaken in the mouse; and (5) duplicates of Nlrp4 and 9 in the mouse might have been subjected to adaptive evolution. Conclusion In conclusion, this study brings us novel information on the evolution of mammalian reproduction-related NLRPs . On the one hand, NLRP genes duplicated and functionally diversified in mammalian reproductive systems (such as NLRP4 , 5 , 9 and 14 ). On the other hand, during evolution, different lineages adapted to develop their own NLRP genes, particularly in reproductive function (such as the specific expansion of Nlrp4 and Nlrp9 in the mouse)." @default.
• W2000842113 created "2016-06-24" @default.
• W2000842113 creator A5024548832 @default.
• W2000842113 creator A5065146893 @default.
• W2000842113 creator A5083621153 @default.
• W2000842113 date "2009-08-14" @default.
• W2000842113 modified "2023-10-04" @default.
• W2000842113 title "Evolution and functional divergence of NLRPgenes in mammalian reproductive systems" @default.
• W2000842113 cites W1513297807 @default.
• W2000842113 cites W1529674879 @default.
• W2000842113 cites W1551836412 @default.
• W2000842113 cites W1836809038 @default.
• W2000842113 cites W1851719328 @default.
• W2000842113 cites W1968002146 @default.
• W2000842113 cites W1969603232 @default.
• W2000842113 cites W1972745528 @default.
• W2000842113 cites W1987571626 @default.
• W2000842113 cites W1987807346 @default.
• W2000842113 cites W2012840807 @default.
• W2000842113 cites W2013798014 @default.
• W2000842113 cites W2018217912 @default.
• W2000842113 cites W2021764172 @default.
• W2000842113 cites W2024445068 @default.
• W2000842113 cites W2027006155 @default.
• W2000842113 cites W2027762334 @default.
• W2000842113 cites W2030572203 @default.
• W2000842113 cites W2032802646 @default.
• W2000842113 cites W2036835673 @default.
• W2000842113 cites W2037369554 @default.
• W2000842113 cites W2038143978 @default.
• W2000842113 cites W2046183549 @default.
• W2000842113 cites W2049309853 @default.
• W2000842113 cites W2051464954 @default.
• W2000842113 cites W2054216909 @default.
• W2000842113 cites W2055941639 @default.
• W2000842113 cites W2058852263 @default.
• W2000842113 cites W2065172786 @default.
• W2000842113 cites W2075705212 @default.
• W2000842113 cites W2076844958 @default.
• W2000842113 cites W2077139488 @default.
• W2000842113 cites W2081285895 @default.
• W2000842113 cites W2088164523 @default.
• W2000842113 cites W2089962751 @default.
• W2000842113 cites W2090144201 @default.
• W2000842113 cites W2092414509 @default.
• W2000842113 cites W2093922429 @default.
• W2000842113 cites W2096259698 @default.
• W2000842113 cites W2100017730 @default.
• W2000842113 cites W2100784450 @default.
• W2000842113 cites W2103546861 @default.
• W2000842113 cites W2104720605 @default.
• W2000842113 cites W2106882534 @default.
• W2000842113 cites W2109840664 @default.
• W2000842113 cites W2110194655 @default.
• W2000842113 cites W2110335151 @default.
• W2000842113 cites W2114315853 @default.
• W2000842113 cites W2114926154 @default.
• W2000842113 cites W2115696271 @default.
• W2000842113 cites W2115910333 @default.
• W2000842113 cites W2123497822 @default.
• W2000842113 cites W2125121305 @default.
• W2000842113 cites W2126854188 @default.
• W2000842113 cites W2127425186 @default.
• W2000842113 cites W2133585817 @default.
• W2000842113 cites W2133917457 @default.
• W2000842113 cites W2135160221 @default.
• W2000842113 cites W2135343017 @default.
• W2000842113 cites W2135645309 @default.
• W2000842113 cites W2137137210 @default.
• W2000842113 cites W2146213764 @default.
• W2000842113 cites W2146884324 @default.
• W2000842113 cites W2146886968 @default.
• W2000842113 cites W2147865566 @default.
• W2000842113 cites W2150771431 @default.
• W2000842113 cites W2152075687 @default.
• W2000842113 cites W2154907719 @default.
• W2000842113 cites W2158714788 @default.
• W2000842113 cites W2160364329 @default.
• W2000842113 cites W2163978414 @default.
• W2000842113 cites W2165810656 @default.
• W2000842113 cites W2165892911 @default.
• W2000842113 cites W2170565120 @default.
• W2000842113 cites W2173367747 @default.
• W2000842113 cites W2214879163 @default.
• W2000842113 cites W4254275792 @default.
• W2000842113 doi "https://doi.org/10.1186/1471-2148-9-202" @default.
• W2000842113 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2735741" @default.
• W2000842113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19682372" @default.
• W2000842113 hasPublicationYear "2009" @default.
• W2000842113 type Work @default.
• W2000842113 sameAs 2000842113 @default.
• W2000842113 citedByCount "139" @default.
• W2000842113 countsByYear W20008421132012 @default.
• W2000842113 countsByYear W20008421132013 @default.
• W2000842113 countsByYear W20008421132014 @default.
• W2000842113 countsByYear W20008421132015 @default.
• W2000842113 countsByYear W20008421132016 @default.
• W2000842113 countsByYear W20008421132017 @default.
• W2000842113 countsByYear W20008421132018 @default.
• W2000842113 countsByYear W20008421132019 @default.

• next