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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000842762> ?p ?o ?g. }

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• W2000842762 abstract "A series of 3-trifluoromethyl-1,2,3,4-tetrahydroisoquinolines was synthesized and evaluated for their phenylethanolamine N-methyltransferase (PNMT) inhibitory potency and affinity for the alpha(2)-adrenoceptor. Although their PNMT inhibitory potency decreased compared with corresponding 3-methyl-, 3-hydroxymethyl- or 3-unsubstituted-THIQs, some of them showed good selectivity due to their extremely low alpha(2)-adrenoceptor affinity." @default.
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• W2000842762 date "2005-12-01" @default.
• W2000842762 modified "2023-09-30" @default.
• W2000842762 title "Inhibitors of phenylethanolamine N-methyltransferase devoid of α2-adrenoceptor affinity" @default.
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• W2000842762 doi "https://doi.org/10.1016/j.bmcl.2005.08.033" @default.
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