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- W2000844825 abstract "Type 1 interferons alpha and beta are found to be potent inhibitors of IL-7-induced growth of early B lineage cells, while having no effect on cell growth induced by IL-2, IL-3, IL-4, or autogenous factors. The combination of IL-7 and interferons alpha/beta induces bcl-2 down-regulation and cell death by apoptosis. These conclusions were derived initially from experiments employing exogenous cytokines, but functional type 1 interferons are also shown to be produced by resident bone marrow macrophages. As physiological modulators of IL-7-driven proliferation and cell survival, interferons alpha/beta may cooperate with other homeostatic factors to maintain the balanced production of normal B lineage cells." @default.
- W2000844825 created "2016-06-24" @default.
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- W2000844825 date "1995-10-01" @default.
- W2000844825 modified "2023-10-16" @default.
- W2000844825 title "Resident bone marrow macrophages produce type 1 interferons that can selectively inhibit interleukin-7-driven growth of B lineage cells" @default.
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- W2000844825 doi "https://doi.org/10.1016/1074-7613(95)90176-0" @default.
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