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- W2000845051 abstract "The major purpose of this and related projects has been the study of processes integrating cardiac and cardiac tissue activity. Factors modifying the effectiveness of integrative processes have been identified. In the present instance a comparative study of pulsus alternans was made using cat papillary muscle, guinea pig, frog and turtle ventricular strips. Alternation due to population participation variation was found in amphibian and reptilian hearts, but no “uncoupling” such as seen in mammalian tissue even at low temperatures and under hyperosmotic conditions. Rate thresholds for various alternations were determined for mammalian papillary muscle and the effects of temperature, of calcium and magnesium ion concentration change, and of various drugs (epinephrine, acetylcholine, DNP) were determined. The fact that action potentials associated with the stronger contractions had a shorter peak or early repolarization phase duration was noted. Possible explanations of the alternations observed were offered." @default.
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- W2000845051 date "1968-01-01" @default.
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- W2000845051 title "Comparative studies of electrical and mechanical alternation in heart cells" @default.
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- W2000845051 doi "https://doi.org/10.1016/s0022-0736(68)80004-4" @default.
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