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- W2000845566 endingPage "329" @default.
- W2000845566 startingPage "319" @default.
- W2000845566 abstract "The pathogenesis of schizophrenia may be ascribed to early maldevelopment of brain tissue. Neurotrophins are a group of dimeric proteins that affect the development of the nervous system in all vertebrates' species. Since neurotrophins, as well as other growth factors, play a crucial role in neurodevelopment, they are plausible candidates of taking part in the pathophysiology of schizophrenia. In line with this hypothesis, accumulating preclinical and clinical data indicate that dysfunctions of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) may contribute to impaired brain development, neuroplasticity and synaptic dysconnectivity leading to the schizophrenic syndrome, or at least some of its presentations. This article reviews the functions of neurotrophins in the complex process of normal brain development, and their possible relevance to the neuropathology and neuropharmacology of schizophrenia. Further research in this area may bring about novel pharmacological therapeutic strategies to this chronic debilitating disorder." @default.
- W2000845566 created "2016-06-24" @default.
- W2000845566 creator A5011024834 @default.
- W2000845566 creator A5063898483 @default.
- W2000845566 date "2005-05-01" @default.
- W2000845566 modified "2023-10-15" @default.
- W2000845566 title "The possible role of neurotrophins in the pathogenesis and therapy of schizophrenia" @default.
- W2000845566 cites W119748675 @default.
- W2000845566 cites W1539593910 @default.
- W2000845566 cites W1600830780 @default.
- W2000845566 cites W1631745757 @default.
- W2000845566 cites W1892986894 @default.
- W2000845566 cites W1956227640 @default.
- W2000845566 cites W1966133968 @default.
- W2000845566 cites W1967336797 @default.
- W2000845566 cites W1967511986 @default.
- W2000845566 cites W1969449202 @default.
- W2000845566 cites W1969565540 @default.
- W2000845566 cites W1970681490 @default.
- W2000845566 cites W1971156703 @default.
- W2000845566 cites W1971744121 @default.
- W2000845566 cites W1973531344 @default.
- W2000845566 cites W1974215491 @default.
- W2000845566 cites W1979496428 @default.
- W2000845566 cites W1979551767 @default.
- W2000845566 cites W1979896676 @default.
- W2000845566 cites W1980230049 @default.
- W2000845566 cites W1981870344 @default.
- W2000845566 cites W1981881657 @default.
- W2000845566 cites W1984218330 @default.
- W2000845566 cites W1984470001 @default.
- W2000845566 cites W1985638448 @default.
- W2000845566 cites W1986353937 @default.
- W2000845566 cites W1988791308 @default.
- W2000845566 cites W1990809838 @default.
- W2000845566 cites W1991199561 @default.
- W2000845566 cites W1993206740 @default.
- W2000845566 cites W1995362640 @default.
- W2000845566 cites W1995974861 @default.
- W2000845566 cites W1999537405 @default.
- W2000845566 cites W2000891074 @default.
- W2000845566 cites W2001382455 @default.
- W2000845566 cites W2001385420 @default.
- W2000845566 cites W2002242904 @default.
- W2000845566 cites W2004552741 @default.
- W2000845566 cites W2005891675 @default.
- W2000845566 cites W2005940536 @default.
- W2000845566 cites W2018580320 @default.
- W2000845566 cites W2018911801 @default.
- W2000845566 cites W2019391453 @default.
- W2000845566 cites W2022662543 @default.
- W2000845566 cites W2027475151 @default.
- W2000845566 cites W2027988197 @default.
- W2000845566 cites W2029171713 @default.
- W2000845566 cites W2032804593 @default.
- W2000845566 cites W2038563688 @default.
- W2000845566 cites W2040547119 @default.
- W2000845566 cites W2041609945 @default.
- W2000845566 cites W2047019449 @default.
- W2000845566 cites W2049259050 @default.
- W2000845566 cites W2050386936 @default.
- W2000845566 cites W2051600135 @default.
- W2000845566 cites W2052445668 @default.
- W2000845566 cites W2054354916 @default.
- W2000845566 cites W2055647211 @default.
- W2000845566 cites W2055899482 @default.
- W2000845566 cites W2056041896 @default.
- W2000845566 cites W2058650902 @default.
- W2000845566 cites W2059631901 @default.
- W2000845566 cites W2061298800 @default.
- W2000845566 cites W2062648684 @default.
- W2000845566 cites W2062674478 @default.
- W2000845566 cites W2065453508 @default.
- W2000845566 cites W2066805539 @default.
- W2000845566 cites W2069803121 @default.
- W2000845566 cites W2072862965 @default.
- W2000845566 cites W2074077703 @default.
- W2000845566 cites W2074325113 @default.
- W2000845566 cites W2074387130 @default.
- W2000845566 cites W2076004981 @default.
- W2000845566 cites W2076581069 @default.
- W2000845566 cites W2079792601 @default.
- W2000845566 cites W2080140632 @default.
- W2000845566 cites W2082739481 @default.
- W2000845566 cites W2089454493 @default.
- W2000845566 cites W2090398996 @default.
- W2000845566 cites W2091222457 @default.
- W2000845566 cites W2093068765 @default.
- W2000845566 cites W2097809224 @default.
- W2000845566 cites W2099452732 @default.
- W2000845566 cites W2102353290 @default.
- W2000845566 cites W2103217995 @default.
- W2000845566 cites W2105789105 @default.
- W2000845566 cites W2112089287 @default.
- W2000845566 cites W2114216374 @default.
- W2000845566 cites W2116947209 @default.
- W2000845566 cites W2118813298 @default.
- W2000845566 cites W2125268245 @default.