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- W2000845719 abstract "Nerve growth factor (NGF) deprivation was produced in adult rats and guinea pigs by immunization against mouse NGF. Exposure of adult animals to anti-NGF had no effect on sensory ganglion neuronal number or size-frequency histograms. However, the substance P content of sensory ganglia, spinal cord and hind paw skin decreased to as great an extent as was seen in animals exposed to anti-NGF in utero. We conclude that NGF has two separate effects on sensory neurons: adult sensory neurons require NGF for normal function whereas developing neurons require NGF for both survival and transmitter expression." @default.
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- W2000845719 date "1982-07-01" @default.
- W2000845719 modified "2023-09-30" @default.
- W2000845719 title "Effect of exposure to anti-NGF on sensory neurons of adult rats and guinea pigs" @default.
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- W2000845719 doi "https://doi.org/10.1016/0006-8993(82)90102-0" @default.
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