FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000846615> ?p ?o ?g. }

• W2000846615 endingPage "760" @default.
• W2000846615 startingPage "753" @default.
• W2000846615 abstract "Previous studies have shown that androgen up-regulates expression of the p21 (WAF1, CIP1, SDI1, CAP20) gene, which contains a canonical androgen response element (ARE) in its proximal promoter region. We undertook the current studies to determine whether elements in the p21 promoter other than the ARE mediate androgen action. We found that deletion of the ARE did not completely abolish the promoter responsiveness to androgen, suggesting that additional cis-regulatory elements within the p21 core promoter may also be involved in androgen responsiveness. The p21 core promoter is GC-rich and contains six binding sites for transcription factor Sp1. We determined whether one or more of these Sp1 sites mediate androgen responsiveness of the p21 promoter. To do so, we used a transient transfection assay with p21 promoter-luciferase reporter constructs. The reporter activity of a construct lacking the ARE but containing all six Sp1 sites was induced approximately 3-fold by androgen. Mutation of Sp1–3 nearly eliminated basal promoter activity as well as androgen responsiveness, whereas deletion of Sp1–1 and Sp1–2 sites and mutation of Sp1–4, Sp1–5, and Sp1–6 sites had relatively little effect. We also used the mammalian one-hybrid assay and coimmunoprecipitation assay to show that androgen receptor (AR) and transcription factor Sp1 interact with one another. The current studies suggest a model in which AR and transcription factor Sp1 not only bind to their respective consensus sites within the p21 promoter, but also complex with one another, thereby recruiting coactivators and general transcription factors and inducing p21 transcription." @default.
• W2000846615 created "2016-06-24" @default.
• W2000846615 creator A5034635531 @default.
• W2000846615 creator A5044064023 @default.
• W2000846615 creator A5058660962 @default.
• W2000846615 date "2000-05-01" @default.
• W2000846615 modified "2023-10-04" @default.
• W2000846615 title "Androgen Induction of Cyclin-Dependent Kinase Inhibitor p21 Gene: Role of Androgen Receptor and Transcription Factor Sp1 Complex" @default.
• W2000846615 cites W1493920337 @default.
• W2000846615 cites W1497166977 @default.
• W2000846615 cites W1566472466 @default.
• W2000846615 cites W1611268078 @default.
• W2000846615 cites W1837186493 @default.
• W2000846615 cites W1922521877 @default.
• W2000846615 cites W1973361095 @default.
• W2000846615 cites W1984021794 @default.
• W2000846615 cites W1991494214 @default.
• W2000846615 cites W1997348862 @default.
• W2000846615 cites W2000930609 @default.
• W2000846615 cites W2006116250 @default.
• W2000846615 cites W2006678193 @default.
• W2000846615 cites W2008506563 @default.
• W2000846615 cites W2013673460 @default.
• W2000846615 cites W2015519364 @default.
• W2000846615 cites W2015892679 @default.
• W2000846615 cites W2018183560 @default.
• W2000846615 cites W2027586930 @default.
• W2000846615 cites W2043672573 @default.
• W2000846615 cites W2051316659 @default.
• W2000846615 cites W2053648381 @default.
• W2000846615 cites W2063835289 @default.
• W2000846615 cites W2066707764 @default.
• W2000846615 cites W2070199231 @default.
• W2000846615 cites W2073415946 @default.
• W2000846615 cites W2076764916 @default.
• W2000846615 cites W2081501399 @default.
• W2000846615 cites W2096654038 @default.
• W2000846615 cites W2113732478 @default.
• W2000846615 cites W2119725374 @default.
• W2000846615 cites W2128539416 @default.
• W2000846615 cites W2135666845 @default.
• W2000846615 cites W2146829090 @default.
• W2000846615 cites W2162741492 @default.
• W2000846615 cites W2163207663 @default.
• W2000846615 cites W2172256092 @default.
• W2000846615 cites W2617270016 @default.
• W2000846615 doi "https://doi.org/10.1210/mend.14.5.0461" @default.
• W2000846615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10809237" @default.
• W2000846615 hasPublicationYear "2000" @default.
• W2000846615 type Work @default.
• W2000846615 sameAs 2000846615 @default.
• W2000846615 citedByCount "145" @default.
• W2000846615 countsByYear W20008466152012 @default.
• W2000846615 countsByYear W20008466152013 @default.
• W2000846615 countsByYear W20008466152014 @default.
• W2000846615 countsByYear W20008466152015 @default.
• W2000846615 countsByYear W20008466152016 @default.
• W2000846615 countsByYear W20008466152017 @default.
• W2000846615 countsByYear W20008466152018 @default.
• W2000846615 countsByYear W20008466152019 @default.
• W2000846615 countsByYear W20008466152020 @default.
• W2000846615 countsByYear W20008466152021 @default.
• W2000846615 countsByYear W20008466152022 @default.
• W2000846615 countsByYear W20008466152023 @default.
• W2000846615 crossrefType "journal-article" @default.
• W2000846615 hasAuthorship W2000846615A5034635531 @default.
• W2000846615 hasAuthorship W2000846615A5044064023 @default.
• W2000846615 hasAuthorship W2000846615A5058660962 @default.
• W2000846615 hasBestOaLocation W20008466151 @default.
• W2000846615 hasConcept C101762097 @default.
• W2000846615 hasConcept C104317684 @default.
• W2000846615 hasConcept C121608353 @default.
• W2000846615 hasConcept C134018914 @default.
• W2000846615 hasConcept C138599941 @default.
• W2000846615 hasConcept C138885662 @default.
• W2000846615 hasConcept C144825837 @default.
• W2000846615 hasConcept C150194340 @default.
• W2000846615 hasConcept C153911025 @default.
• W2000846615 hasConcept C161733203 @default.
• W2000846615 hasConcept C179926584 @default.
• W2000846615 hasConcept C191163429 @default.
• W2000846615 hasConcept C24284526 @default.
• W2000846615 hasConcept C2777911890 @default.
• W2000846615 hasConcept C2780192828 @default.
• W2000846615 hasConcept C41895202 @default.
• W2000846615 hasConcept C502942594 @default.
• W2000846615 hasConcept C54355233 @default.
• W2000846615 hasConcept C57467964 @default.
• W2000846615 hasConcept C61367390 @default.
• W2000846615 hasConcept C71315377 @default.
• W2000846615 hasConcept C86339819 @default.
• W2000846615 hasConcept C86803240 @default.
• W2000846615 hasConceptScore W2000846615C101762097 @default.
• W2000846615 hasConceptScore W2000846615C104317684 @default.
• W2000846615 hasConceptScore W2000846615C121608353 @default.
• W2000846615 hasConceptScore W2000846615C134018914 @default.
• W2000846615 hasConceptScore W2000846615C138599941 @default.
• W2000846615 hasConceptScore W2000846615C138885662 @default.

• next