Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000846980> ?p ?o ?g. }
- W2000846980 endingPage "786" @default.
- W2000846980 startingPage "778" @default.
- W2000846980 abstract "RhoC oncogene is a well characterized marker of metastasis in a majority of invasive cancers, including HNSCC. Elevated RhoC expression has been found to be associated with distant metastasis. Statins are a class of drugs that are used to reduce cholesterol levels by inhibiting HMG-CoA reductase activity which in turns prevents mevalonate synthesis, which is a precursor for synthesis of cholesterol and prenylation. Interestingly, the proper function of Rho proteins depends on prenylation. Significantly, it has been reported that metastasis in human melanoma can be reduced by atorvastatin which inhibits RhoC activity by preventing its geranylgeranylation. Given that RhoC is a key oncogene involved in metastasis, we hypothesized Atorvastatin can reduce head and neck metastasis by inhibiting RhoC activity. In vitro and in vivo studies were carried out to evaluate the ability of Atorvastatin to inhibit RhoC function and HNSCC metastasis. Cell motility, proliferation, cell invasion, and colony formation assays were performed according to the standard protocols. Atorvastatin treatment significantly reduced the active form of RhoC in vitro and diminished cell motility, invasion, proliferation and colony formation. Importantly, we observed a significant decrease in p-ERK1/2 and p-STAT3 in Atorvastatin treated cell lines. In vivo experiments revealed inhibition of angiogenesis and lung metastases with Atorvastatin therapy. This study is the first of its kind to establish a potential role of Atorvastatin in head and neck cancer therapy. These findings suggest that Atorvastatin can be a potential low risk adjuvant therapy to minimize metastases in aggressive forms of HNSCC." @default.
- W2000846980 created "2016-06-24" @default.
- W2000846980 creator A5022366068 @default.
- W2000846980 creator A5065768960 @default.
- W2000846980 creator A5070081712 @default.
- W2000846980 creator A5083969516 @default.
- W2000846980 date "2013-08-01" @default.
- W2000846980 modified "2023-09-28" @default.
- W2000846980 title "Atorvastatin inhibits RhoC function and limits head and neck cancer metastasis" @default.
- W2000846980 cites W1488783311 @default.
- W2000846980 cites W1521040509 @default.
- W2000846980 cites W1550875496 @default.
- W2000846980 cites W1686570062 @default.
- W2000846980 cites W1949238489 @default.
- W2000846980 cites W1965015213 @default.
- W2000846980 cites W1966023484 @default.
- W2000846980 cites W1969875009 @default.
- W2000846980 cites W1975108009 @default.
- W2000846980 cites W1976551983 @default.
- W2000846980 cites W1977834924 @default.
- W2000846980 cites W1985723830 @default.
- W2000846980 cites W1986756922 @default.
- W2000846980 cites W1990956554 @default.
- W2000846980 cites W1992134233 @default.
- W2000846980 cites W1993641273 @default.
- W2000846980 cites W2007285929 @default.
- W2000846980 cites W2007660746 @default.
- W2000846980 cites W2008346541 @default.
- W2000846980 cites W2023630604 @default.
- W2000846980 cites W2025047668 @default.
- W2000846980 cites W2049206854 @default.
- W2000846980 cites W2049623935 @default.
- W2000846980 cites W2055469883 @default.
- W2000846980 cites W2061942566 @default.
- W2000846980 cites W2072400772 @default.
- W2000846980 cites W2074934843 @default.
- W2000846980 cites W2079430799 @default.
- W2000846980 cites W2087514248 @default.
- W2000846980 cites W2096791952 @default.
- W2000846980 cites W2097463362 @default.
- W2000846980 cites W2113640115 @default.
- W2000846980 cites W2121836743 @default.
- W2000846980 cites W2124215421 @default.
- W2000846980 cites W2127754394 @default.
- W2000846980 cites W2132834292 @default.
- W2000846980 cites W2140826939 @default.
- W2000846980 cites W2147191052 @default.
- W2000846980 cites W2147777207 @default.
- W2000846980 cites W2151901542 @default.
- W2000846980 cites W2166249402 @default.
- W2000846980 cites W2166843593 @default.
- W2000846980 cites W2167626680 @default.
- W2000846980 cites W2313364580 @default.
- W2000846980 cites W2397257832 @default.
- W2000846980 cites W2409820575 @default.
- W2000846980 cites W2471043347 @default.
- W2000846980 cites W4242397592 @default.
- W2000846980 doi "https://doi.org/10.1016/j.oraloncology.2013.04.003" @default.
- W2000846980 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4299638" @default.
- W2000846980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23648017" @default.
- W2000846980 hasPublicationYear "2013" @default.
- W2000846980 type Work @default.
- W2000846980 sameAs 2000846980 @default.
- W2000846980 citedByCount "44" @default.
- W2000846980 countsByYear W20008469802013 @default.
- W2000846980 countsByYear W20008469802014 @default.
- W2000846980 countsByYear W20008469802015 @default.
- W2000846980 countsByYear W20008469802016 @default.
- W2000846980 countsByYear W20008469802017 @default.
- W2000846980 countsByYear W20008469802018 @default.
- W2000846980 countsByYear W20008469802019 @default.
- W2000846980 countsByYear W20008469802020 @default.
- W2000846980 countsByYear W20008469802021 @default.
- W2000846980 countsByYear W20008469802022 @default.
- W2000846980 countsByYear W20008469802023 @default.
- W2000846980 crossrefType "journal-article" @default.
- W2000846980 hasAuthorship W2000846980A5022366068 @default.
- W2000846980 hasAuthorship W2000846980A5065768960 @default.
- W2000846980 hasAuthorship W2000846980A5070081712 @default.
- W2000846980 hasAuthorship W2000846980A5083969516 @default.
- W2000846980 hasBestOaLocation W20008469802 @default.
- W2000846980 hasConcept C121608353 @default.
- W2000846980 hasConcept C126322002 @default.
- W2000846980 hasConcept C2776530083 @default.
- W2000846980 hasConcept C2776833033 @default.
- W2000846980 hasConcept C2777482532 @default.
- W2000846980 hasConcept C2779013556 @default.
- W2000846980 hasConcept C2779473599 @default.
- W2000846980 hasConcept C2781018059 @default.
- W2000846980 hasConcept C29537977 @default.
- W2000846980 hasConcept C502942594 @default.
- W2000846980 hasConcept C71924100 @default.
- W2000846980 hasConcept C86803240 @default.
- W2000846980 hasConceptScore W2000846980C121608353 @default.
- W2000846980 hasConceptScore W2000846980C126322002 @default.
- W2000846980 hasConceptScore W2000846980C2776530083 @default.
- W2000846980 hasConceptScore W2000846980C2776833033 @default.
- W2000846980 hasConceptScore W2000846980C2777482532 @default.