FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000847178> ?p ?o ?g. }

• W2000847178 endingPage "e1318" @default.
• W2000847178 startingPage "e1318" @default.
• W2000847178 abstract "Significant advances have been made in the development of small molecules blocking the p53/MDM2 interaction. The Mdm2 inhibitor Nutlin-3 is restricted to tumors carrying wtp53. In contrast, RITA, a compound that binds p53, has recently been shown also to restore transcriptional functions of mtp53. As more than 50% of solid tumors carry p53 mutations, RITA promises to be a more effective therapeutic strategy than Nutlin-3. We investigated effects of RITA on apoptosis, cell cycle and induction of 45 p53 target genes in a panel of 14 cell lines from different tumor entities with different p53 status as well as primary lymphocytes and fibroblasts. Nine cell strains expressed wtp53, four harbored mtp53, and three were characterized by the loss of p53 protein. A significant induction of cell death upon RITA was observed in 7 of 16 cell lines. The nonmalignant cells in our panel were substantially less sensitive. We found that in contrast to Nultin-3, RITA is capable to induce cell death not only in tumor cells harboring wtp53 and mtp53 but also in p53-null cells. Importantly, whereas p53 has a central role for RITA-mediated effects in wtp53 cells, neither p53 nor p63 or p73 were essential for the RITA response in mtp53 or p53-null cells in our panel demonstrating that besides the known p53-dependent action of RITA in wtp53 cells, RITA can induce cell death also independently of p53 in cells harboring defective p53. We identified an important role of both p38 and JNK/SAPK for sensitivity to RITA in these cells leading to a typical caspase- and BAX/BAK-dependent mitochondrial apoptosis. In conclusion, our data demonstrate that RITA can induce apoptosis through p38 and JNK/SAPK not only in tumor cells harboring wtp53 and mtp53 but also in p53-null cells, making RITA an interesting tumor-selective drug." @default.
• W2000847178 created "2016-06-24" @default.
• W2000847178 creator A5016871874 @default.
• W2000847178 creator A5025716518 @default.
• W2000847178 creator A5036387444 @default.
• W2000847178 creator A5047674033 @default.
• W2000847178 creator A5084729483 @default.
• W2000847178 date "2014-07-10" @default.
• W2000847178 modified "2023-10-16" @default.
• W2000847178 title "RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38" @default.
• W2000847178 cites W148936752 @default.
• W2000847178 cites W1616121322 @default.
• W2000847178 cites W1823288226 @default.
• W2000847178 cites W1964719993 @default.
• W2000847178 cites W1966163762 @default.
• W2000847178 cites W1968075505 @default.
• W2000847178 cites W1976295398 @default.
• W2000847178 cites W1977082403 @default.
• W2000847178 cites W1980250100 @default.
• W2000847178 cites W1983357242 @default.
• W2000847178 cites W1993263392 @default.
• W2000847178 cites W1996745436 @default.
• W2000847178 cites W2009096172 @default.
• W2000847178 cites W2009747291 @default.
• W2000847178 cites W2015619266 @default.
• W2000847178 cites W2019081978 @default.
• W2000847178 cites W2024468216 @default.
• W2000847178 cites W2028553570 @default.
• W2000847178 cites W2033787501 @default.
• W2000847178 cites W2040737963 @default.
• W2000847178 cites W2045889399 @default.
• W2000847178 cites W2053847776 @default.
• W2000847178 cites W2054188457 @default.
• W2000847178 cites W2056543772 @default.
• W2000847178 cites W2059021281 @default.
• W2000847178 cites W2060664717 @default.
• W2000847178 cites W2063953032 @default.
• W2000847178 cites W2068543804 @default.
• W2000847178 cites W2075537604 @default.
• W2000847178 cites W2075554815 @default.
• W2000847178 cites W2080389159 @default.
• W2000847178 cites W2081116987 @default.
• W2000847178 cites W2086042427 @default.
• W2000847178 cites W2088205139 @default.
• W2000847178 cites W2092716869 @default.
• W2000847178 cites W2092770931 @default.
• W2000847178 cites W2093775600 @default.
• W2000847178 cites W2097072837 @default.
• W2000847178 cites W2097933346 @default.
• W2000847178 cites W2099113454 @default.
• W2000847178 cites W2112396116 @default.
• W2000847178 cites W2114265700 @default.
• W2000847178 cites W2118096237 @default.
• W2000847178 cites W2123184912 @default.
• W2000847178 cites W2127551600 @default.
• W2000847178 cites W2130665205 @default.
• W2000847178 cites W2133959309 @default.
• W2000847178 cites W2135458195 @default.
• W2000847178 cites W2148435534 @default.
• W2000847178 cites W2148542575 @default.
• W2000847178 cites W2160345685 @default.
• W2000847178 cites W2162160107 @default.
• W2000847178 cites W2171407623 @default.
• W2000847178 cites W2172215449 @default.
• W2000847178 doi "https://doi.org/10.1038/cddis.2014.284" @default.
• W2000847178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4123078" @default.
• W2000847178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25010984" @default.
• W2000847178 hasPublicationYear "2014" @default.
• W2000847178 type Work @default.
• W2000847178 sameAs 2000847178 @default.
• W2000847178 citedByCount "50" @default.
• W2000847178 countsByYear W20008471782015 @default.
• W2000847178 countsByYear W20008471782016 @default.
• W2000847178 countsByYear W20008471782017 @default.
• W2000847178 countsByYear W20008471782018 @default.
• W2000847178 countsByYear W20008471782019 @default.
• W2000847178 countsByYear W20008471782020 @default.
• W2000847178 countsByYear W20008471782021 @default.
• W2000847178 countsByYear W20008471782022 @default.
• W2000847178 countsByYear W20008471782023 @default.
• W2000847178 crossrefType "journal-article" @default.
• W2000847178 hasAuthorship W2000847178A5016871874 @default.
• W2000847178 hasAuthorship W2000847178A5025716518 @default.
• W2000847178 hasAuthorship W2000847178A5036387444 @default.
• W2000847178 hasAuthorship W2000847178A5047674033 @default.
• W2000847178 hasAuthorship W2000847178A5084729483 @default.
• W2000847178 hasBestOaLocation W20008471781 @default.
• W2000847178 hasConcept C104317684 @default.
• W2000847178 hasConcept C121853132 @default.
• W2000847178 hasConcept C127561419 @default.
• W2000847178 hasConcept C1491633281 @default.
• W2000847178 hasConcept C153911025 @default.
• W2000847178 hasConcept C190283241 @default.
• W2000847178 hasConcept C2776192174 @default.
• W2000847178 hasConcept C2778264664 @default.
• W2000847178 hasConcept C29537977 @default.
• W2000847178 hasConcept C31573885 @default.
• W2000847178 hasConcept C502942594 @default.

• next