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• W2000848291 abstract "The lipid extract of an Indonesian Lendenfeldia sp. sponge inhibited hypoxia-induced hypoxia-inducible factor-1 (HIF-1) activation in T47D breast tumor cells. Chromatographic separation yielded the new substituted naphthalene dimer 1, the new furanolipid 2, and three known homoscalarane sesterterpenes, 3–5. Compounds 1 and 3–5 inhibited hypoxia-induced HIF-1 activation (IC50 values: 0.64–6.9 µM), but also reduced the viability of T47D and MDA-MB- 231 breast tumor cells. Compound 4 was the most potent and showed a unique tumor cell line selectivity in the NCI 60-cell line panel. The general cytotoxicity of these compounds precluded their further consideration as HIF-1 inhibitors." @default.
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• W2000848291 date "2007-10-25" @default.
• W2000848291 modified "2023-10-02" @default.
• W2000848291 title "Cytotoxic Metabolites from an Indonesian Sponge <i>Lendenfeldia</i> sp." @default.
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• W2000848291 doi "https://doi.org/10.1021/np070337f" @default.
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