Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000849105> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2000849105 endingPage "1357" @default.
- W2000849105 startingPage "1346" @default.
- W2000849105 abstract "This is the first study to report results from a noninvasive dual-tracer positron emission tomography (PET) in humans not requiring arterial sampling, in which two radiotracers were injected closely in time within the same scan. These studies yield near simultaneous information on two different neuropharmacological systems, providing better characterization of a subject's neurologic condition. The noninvasive dual-tracer approach described in this study is based on the primary assumption that an appropriate bolus plus constant infusion protocol brings the reference tissue of the first radiotracer to steady state before injection of the second tracer. Two methods for separation of time-activity curves (TACs) and parameter estimation were investigated, namely (1) an extrapolation method, in which TACs of the first tracer were extrapolated over total scan duration followed by subtraction from dual-tracer TACs and (2) a simultaneous fitting method, in which reference-region models for both tracers were fitted simultaneously to dual-tracer TACs. Combinations of two reversible tracers ([ 11 C]flumazenil and [ 11 C]dihydrotetrabenazine) or one reversible and one irreversible tracer ([ 11 C] N-methylpiperidinyl propionate) were used. After the dual-tracer scan, a single-tracer (ST) scan using one of the tracers was obtained for comparison of the dual-tracer results. Both approaches provided parameter estimates with intersubject regions-of-interest means typically within 10% of those obtained from ST scans without an appreciable increase in variance." @default.
- W2000849105 created "2016-06-24" @default.
- W2000849105 creator A5027207271 @default.
- W2000849105 creator A5046436153 @default.
- W2000849105 creator A5083886913 @default.
- W2000849105 creator A5087492627 @default.
- W2000849105 date "2009-04-29" @default.
- W2000849105 modified "2023-09-25" @default.
- W2000849105 title "Signal Separation and Parameter Estimation in Noninvasive Dual-Tracer PET Scans using Reference-Region Approaches" @default.
- W2000849105 cites W1593546622 @default.
- W2000849105 cites W1968931139 @default.
- W2000849105 cites W1972740470 @default.
- W2000849105 cites W1972821873 @default.
- W2000849105 cites W1976112975 @default.
- W2000849105 cites W1986159971 @default.
- W2000849105 cites W2003090874 @default.
- W2000849105 cites W2041631206 @default.
- W2000849105 cites W2042056135 @default.
- W2000849105 cites W2050443585 @default.
- W2000849105 cites W2074682417 @default.
- W2000849105 cites W2077854091 @default.
- W2000849105 cites W2080631640 @default.
- W2000849105 cites W2086209836 @default.
- W2000849105 cites W2091088809 @default.
- W2000849105 cites W2093374860 @default.
- W2000849105 cites W2105168883 @default.
- W2000849105 cites W2112278807 @default.
- W2000849105 cites W2117671988 @default.
- W2000849105 cites W2122554567 @default.
- W2000849105 cites W2146892597 @default.
- W2000849105 cites W2154744699 @default.
- W2000849105 cites W4242720768 @default.
- W2000849105 doi "https://doi.org/10.1038/jcbfm.2009.53" @default.
- W2000849105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19401708" @default.
- W2000849105 hasPublicationYear "2009" @default.
- W2000849105 type Work @default.
- W2000849105 sameAs 2000849105 @default.
- W2000849105 citedByCount "22" @default.
- W2000849105 countsByYear W20008491052013 @default.
- W2000849105 countsByYear W20008491052014 @default.
- W2000849105 countsByYear W20008491052015 @default.
- W2000849105 countsByYear W20008491052016 @default.
- W2000849105 countsByYear W20008491052017 @default.
- W2000849105 countsByYear W20008491052018 @default.
- W2000849105 countsByYear W20008491052019 @default.
- W2000849105 countsByYear W20008491052020 @default.
- W2000849105 countsByYear W20008491052021 @default.
- W2000849105 countsByYear W20008491052022 @default.
- W2000849105 countsByYear W20008491052023 @default.
- W2000849105 crossrefType "journal-article" @default.
- W2000849105 hasAuthorship W2000849105A5027207271 @default.
- W2000849105 hasAuthorship W2000849105A5046436153 @default.
- W2000849105 hasAuthorship W2000849105A5083886913 @default.
- W2000849105 hasAuthorship W2000849105A5087492627 @default.
- W2000849105 hasBestOaLocation W20008491051 @default.
- W2000849105 hasConcept C121332964 @default.
- W2000849105 hasConcept C132459708 @default.
- W2000849105 hasConcept C134306372 @default.
- W2000849105 hasConcept C136229726 @default.
- W2000849105 hasConcept C185544564 @default.
- W2000849105 hasConcept C185592680 @default.
- W2000849105 hasConcept C2775842073 @default.
- W2000849105 hasConcept C2778863792 @default.
- W2000849105 hasConcept C2989005 @default.
- W2000849105 hasConcept C33923547 @default.
- W2000849105 hasConcept C71924100 @default.
- W2000849105 hasConceptScore W2000849105C121332964 @default.
- W2000849105 hasConceptScore W2000849105C132459708 @default.
- W2000849105 hasConceptScore W2000849105C134306372 @default.
- W2000849105 hasConceptScore W2000849105C136229726 @default.
- W2000849105 hasConceptScore W2000849105C185544564 @default.
- W2000849105 hasConceptScore W2000849105C185592680 @default.
- W2000849105 hasConceptScore W2000849105C2775842073 @default.
- W2000849105 hasConceptScore W2000849105C2778863792 @default.
- W2000849105 hasConceptScore W2000849105C2989005 @default.
- W2000849105 hasConceptScore W2000849105C33923547 @default.
- W2000849105 hasConceptScore W2000849105C71924100 @default.
- W2000849105 hasIssue "7" @default.
- W2000849105 hasLocation W20008491051 @default.
- W2000849105 hasLocation W20008491052 @default.
- W2000849105 hasOpenAccess W2000849105 @default.
- W2000849105 hasPrimaryLocation W20008491051 @default.
- W2000849105 hasRelatedWork W1509727557 @default.
- W2000849105 hasRelatedWork W1991153914 @default.
- W2000849105 hasRelatedWork W2023795550 @default.
- W2000849105 hasRelatedWork W2027448049 @default.
- W2000849105 hasRelatedWork W2080845549 @default.
- W2000849105 hasRelatedWork W2104790266 @default.
- W2000849105 hasRelatedWork W2126201191 @default.
- W2000849105 hasRelatedWork W2132405138 @default.
- W2000849105 hasRelatedWork W2494494343 @default.
- W2000849105 hasRelatedWork W2625634176 @default.
- W2000849105 hasVolume "29" @default.
- W2000849105 isParatext "false" @default.
- W2000849105 isRetracted "false" @default.
- W2000849105 magId "2000849105" @default.
- W2000849105 workType "article" @default.