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- W2000851763 abstract "A stereospecific high-performance liquid chromatographic method for the quantification of (−)- and (+)-tertatolol in plasma and urine is described. The method involves solid-phase extraction followed by derivatization with S(+)-naphthylethylisocyanate to form the urea derivative, which is more sensitive to fluorescence detection. The separation of the diastereomeric derivatives was performed by reversed-phase high-performance liquid chromatography. Fluorimetric detection (λexcitation = 220 nm, λemission = 320 nm) allows the quantification of tertatolol enantiomers down to 6 ng/ml. The assay was used to study the pharmacokinetic profile of tertatolol enantiomers following oral administration of racemic tertatolol; preliminary results suggest enantioselective absorption and/or disposition of tertatolol." @default.
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- W2000851763 date "1991-12-01" @default.
- W2000851763 modified "2023-09-26" @default.
- W2000851763 title "Determination of tertatolol enantiomers in biological fluids by high-performance liquid chromatography" @default.
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- W2000851763 doi "https://doi.org/10.1016/0378-4347(91)80484-t" @default.
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