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- W2000853330 abstract "The gastric mucosa of the dog is rich in histamine. Fluorescence microscopic analysis showed that in this species gastric histamine is stored in mast cells, which differ from mast cells at other sites in that they are resistant to the histamine-releasing action of Compound 48/80. Previously, it has been established that in the rat the major portion of gastric histamine is stored in a specific, enterochromaffin-like epithelial cell system in the oxyntic gland area; in contrast to the enterochromaffin cells of the pyloric region they contain no 5-hydroxytryptamine. A morphologically similar cell system could be demonstrated in the antral region of the dog stomach. In this species, however, these enterochromaffin-like cells are devoid of histamine, as well as of histochemically detectable monoamines. Nevertheless, they were found capable of producing and storing monoamines from exogenous precursor amino acids. In the rat, gastric histamine is probably produced locally since the enterochromaffin-like cells are rich in histidine decarboxylase. Histidine decarboxylase activity in the dog stomach was found to be low, which contrasts with the high gastric histamine content. The origin of gastric histamine in this species is still unknown. It is possible that most of it results from an active uptake of preformed, circulating histamine rather than from local biosynthesis." @default.
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- W2000853330 date "1968-11-01" @default.
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- W2000853330 title "Cellular stores of histamine and monoamines in the dog stomach" @default.
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- W2000853330 doi "https://doi.org/10.1016/0024-3205(68)90283-x" @default.
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