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- W2000853354 abstract "Two experiments have tested the hypothesis that pancreatic sensitivity to diabetogenic agents may be increased by obesity. In the first experiment, lean and hypothalamic obese (VMH) rats were injected with 15, 25, or 35 mg/kg of streptozotocin. The VMH-obese rats showed a dose-related rise in blood glucose but the lean rats only showed a rise in glucose with the highest dose. All obese rats which received 35 mg/kg of streptozotocin died of ketoacidosis, and 3 of the 6 obese rats receiving 25 mg/kg of streptozotocin became diabetic (2 with ketoacidosis). Among the lean rats, only 3 became mildly diabetic. Serum insulin levels were decreased significantly with 25 and 35 mg/kg one week after streptozotocin in the obese rats, but there was no change in the lean rats." @default.
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- W2000853354 date "1978-07-01" @default.
- W2000853354 modified "2023-10-16" @default.
- W2000853354 title "Sensitivity of β-Cells to Streptozotocin in Lean and Obese Rats" @default.
- W2000853354 doi "https://doi.org/10.1055/s-0028-1093413" @default.
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