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- W2000854167 abstract "An inverse correlation was found between the number of pulses and sympathetic blockade by PGE1 (10−8g/ml) in guinea-pig isolated field stimulated atria and vas deferens. The higher the number of pulses applied at a given frequency the smaller was the inhibition by PGE1 of neuroeffector transmission. At 100 shocks using 10 Hz stimulation, PGE1 no longer decreased the height of twitches of the guinea-pig vas deferens, however, the velocity of contractions was decreased. Sympathetic transmission in the rabbit jejunum was blocked by a somewhat higher dose of PGE1 (3 × 10−8g/ml). In this organ an increase in pulse number produced no detectable change in PGE1-induced blockad. At a temperature of 37°C the vas deferens of the guinea-pig was highly sensitive to PGE1, whereas that of the rat was virtually insensitive. On cooling the guinea-pig vas deferens to a temperature of 20°C the sensitivity to PGE1 decreased and the shape of the shock number-effect curve became similar to that observed in that rat vas deferens. It is suggested, that the different shape of the curve may be caused by reduced release and/or effect of an inhibitory substance, probably prostaglandin. The biological responsesobtained with racemic PGE1 were qualitatively identical with those elicited by natural PGE1 the latter being about twice as potent." @default.
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- W2000854167 date "1973-10-01" @default.
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- W2000854167 title "The effect of number of stimuli and rate of stimulation on the inhibition by PGE1 of adrenergic transmission" @default.
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- W2000854167 doi "https://doi.org/10.1016/0014-2999(73)90110-6" @default.
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