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- W2000855906 abstract "It has been proposed that at the neuromuscular junction quanta are made up of subunits, because regularly spaced peaks appear in some histograms of miniature end-plate potential (MEPP) amplitudes. Many sets of MEPP sizes fit lognormal probability distribution functions. I compared sets of MEPP amplitudes from the literature to lognormal distributions, using cumulative plots and a robust test for significance. Some data sets fit a single lognormal distribution, but most required two lognormal subpopulations. This bimodal model is a parsimonious alternative to the subunits hypothesis. I also used graphs in which cumulative MEPP sizes were plotted on the ordinate against probability on the abscissa. Model data sets, generated on the subunit assumptions, produced concave plots. End-plate potential sizes at low quantal outputs—in which we know there are subunits—show the same concave shape. Most of the tested data from the subunit literature produced convex curves." @default.
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- W2000855906 date "1989-02-01" @default.
- W2000855906 modified "2023-10-14" @default.
- W2000855906 title "Statistical and graphical methods for testing the hypothesis that quanta are made up of subunits" @default.
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- W2000855906 doi "https://doi.org/10.1016/0165-0270(89)90054-x" @default.
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