FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000856476> ?p ?o ?g. }

• W2000856476 endingPage "2671" @default.
• W2000856476 startingPage "2667" @default.
• W2000856476 abstract "Previous studies of the magnetic field dependence of the magnetic relaxation rate of solvent protons in protein solutions have indicated that this dependence (called relaxation dispersion) is related to the rotational Brownian motion of the solute proteins. In particular, the dispersion of the longitudinal (spin-lattice) relaxation rate 1/T1 shows a monotonic decrease with increasing field, with an inflection point corresponding to a proton Larmor frequency which is inversely proportional to the orientational relaxation time of the protein. We have now compared the relaxation dispersion of solvent 1H, 2H, and 17O In aqueous solutions of lysozyme (molecular weight 14,700) and 1H and 2H in solutions of hemocyanin (molecular weight 14,7 00) and 1H and 2H in solutions of hemocyanin (molecular weight 9 x 10(6)). The main experimental observation is that the dispersion of the relaxation rates of the three solvent nuclei in lysozyme solutions, normalized to their respective rates in pure water, is essentially the same. This is also true for 1H and 2H relaxation in hemocyanin solutions. These results confirm that entire solvent water molecules, rather than exchanging protons, are involved in the interaction. We have been unable to deduce the correct mechanism to explain the data, but we can eliminate several interaction mechanisms from consideration. For example, all observations combined cannot be explained by a simple two-site model of exchange, in which water molecules are either in sites on the protein with a relaxation rate characteristic of these sites, or else in the bulk solvent (the observed relaxation rate being the weighted average of the two). Also eliminated is the class of models in which the protein molecules induce a preferential partial alignment of neighboring solvent molecules, for example by electrostatic interaction of the electric dipole moments of the water with the electric fields produced by surface charges of the protein molecules. In addition, the idea that relaxation of solvent nuclei is due, in the main, to interactions with protein protons is precluded. Rather, it appears that the protein molecules influence the dynamics of the motion of solvent water molecules in their neighborhood in a manner that imposes on all the solvent molecules a correlation time for their orientational relaxation which equals that of the solute proteins." @default.
• W2000856476 created "2016-06-24" @default.
• W2000856476 creator A5028326396 @default.
• W2000856476 creator A5050417910 @default.
• W2000856476 creator A5059368795 @default.
• W2000856476 date "1975-07-01" @default.
• W2000856476 modified "2023-09-23" @default.
• W2000856476 title "Protein-water interaction studied by solvent 1H, 2H, and 17O magnetic relaxation." @default.
• W2000856476 cites W1512770567 @default.
• W2000856476 cites W1539271460 @default.
• W2000856476 cites W1585550871 @default.
• W2000856476 cites W1990951702 @default.
• W2000856476 cites W1995918309 @default.
• W2000856476 cites W2021980737 @default.
• W2000856476 cites W2034885499 @default.
• W2000856476 cites W2044033134 @default.
• W2000856476 cites W2047404910 @default.
• W2000856476 cites W2064956647 @default.
• W2000856476 cites W2412555134 @default.
• W2000856476 doi "https://doi.org/10.1073/pnas.72.7.2667" @default.
• W2000856476 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/432831" @default.
• W2000856476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1058481" @default.
• W2000856476 hasPublicationYear "1975" @default.
• W2000856476 type Work @default.
• W2000856476 sameAs 2000856476 @default.
• W2000856476 citedByCount "89" @default.
• W2000856476 countsByYear W20008564762012 @default.
• W2000856476 countsByYear W20008564762016 @default.
• W2000856476 countsByYear W20008564762018 @default.
• W2000856476 countsByYear W20008564762019 @default.
• W2000856476 countsByYear W20008564762020 @default.
• W2000856476 countsByYear W20008564762022 @default.
• W2000856476 countsByYear W20008564762023 @default.
• W2000856476 crossrefType "journal-article" @default.
• W2000856476 hasAuthorship W2000856476A5028326396 @default.
• W2000856476 hasAuthorship W2000856476A5050417910 @default.
• W2000856476 hasAuthorship W2000856476A5059368795 @default.
• W2000856476 hasBestOaLocation W20008564761 @default.
• W2000856476 hasConcept C120665830 @default.
• W2000856476 hasConcept C121332964 @default.
• W2000856476 hasConcept C147789679 @default.
• W2000856476 hasConcept C15744967 @default.
• W2000856476 hasConcept C159467904 @default.
• W2000856476 hasConcept C177562468 @default.
• W2000856476 hasConcept C178790620 @default.
• W2000856476 hasConcept C184651966 @default.
• W2000856476 hasConcept C185592680 @default.
• W2000856476 hasConcept C2524010 @default.
• W2000856476 hasConcept C2776029896 @default.
• W2000856476 hasConcept C2780471494 @default.
• W2000856476 hasConcept C33923547 @default.
• W2000856476 hasConcept C46141821 @default.
• W2000856476 hasConcept C74545648 @default.
• W2000856476 hasConcept C77805123 @default.
• W2000856476 hasConcept C97355855 @default.
• W2000856476 hasConceptScore W2000856476C120665830 @default.
• W2000856476 hasConceptScore W2000856476C121332964 @default.
• W2000856476 hasConceptScore W2000856476C147789679 @default.
• W2000856476 hasConceptScore W2000856476C15744967 @default.
• W2000856476 hasConceptScore W2000856476C159467904 @default.
• W2000856476 hasConceptScore W2000856476C177562468 @default.
• W2000856476 hasConceptScore W2000856476C178790620 @default.
• W2000856476 hasConceptScore W2000856476C184651966 @default.
• W2000856476 hasConceptScore W2000856476C185592680 @default.
• W2000856476 hasConceptScore W2000856476C2524010 @default.
• W2000856476 hasConceptScore W2000856476C2776029896 @default.
• W2000856476 hasConceptScore W2000856476C2780471494 @default.
• W2000856476 hasConceptScore W2000856476C33923547 @default.
• W2000856476 hasConceptScore W2000856476C46141821 @default.
• W2000856476 hasConceptScore W2000856476C74545648 @default.
• W2000856476 hasConceptScore W2000856476C77805123 @default.
• W2000856476 hasConceptScore W2000856476C97355855 @default.
• W2000856476 hasIssue "7" @default.
• W2000856476 hasLocation W20008564761 @default.
• W2000856476 hasLocation W20008564762 @default.
• W2000856476 hasLocation W20008564763 @default.
• W2000856476 hasLocation W20008564764 @default.
• W2000856476 hasOpenAccess W2000856476 @default.
• W2000856476 hasPrimaryLocation W20008564761 @default.
• W2000856476 hasRelatedWork W1564251068 @default.
• W2000856476 hasRelatedWork W2009823598 @default.
• W2000856476 hasRelatedWork W2029652789 @default.
• W2000856476 hasRelatedWork W2053205669 @default.
• W2000856476 hasRelatedWork W2503153802 @default.
• W2000856476 hasRelatedWork W2949080510 @default.
• W2000856476 hasRelatedWork W2951261188 @default.
• W2000856476 hasRelatedWork W2951280107 @default.
• W2000856476 hasRelatedWork W2951314393 @default.
• W2000856476 hasRelatedWork W4290569082 @default.
• W2000856476 hasVolume "72" @default.
• W2000856476 isParatext "false" @default.
• W2000856476 isRetracted "false" @default.
• W2000856476 magId "2000856476" @default.
• W2000856476 workType "article" @default.