FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000856761> ?p ?o ?g. }

• W2000856761 endingPage "F880" @default.
• W2000856761 startingPage "F875" @default.
• W2000856761 abstract "Angiotensin-converting enzyme inhibition (ACEI) with captopril has been shown to increase water intake and urine output in rats, but the mechanism is unknown. ACEI impairs the conversion of ANG I to ANG II, a dipsogenic hormone, and impairs the degradation of bradykinin. The goal of this study was to examine the role of bradykinin in the polydipsia and polyuria associated with ACEI. Male Sprague-Dawley rats received captopril (CPT; 20 mg.kg(-1).day(-1)) in ground chow for 48 h. Water intake, food intake, and urine output were monitored and compared with control rats (CTL), rats receiving captopril treatment with limited water intake (CPT-LIM), and rats receiving captopril treatment with ad libitum water intake plus 24-h treatment with the bradykinin antagonist B-9430 (CPT-BK1). CPT rats consumed significantly more water and produced more urine vs. CTL. Urine osmolality was significantly decreased in CPT rats vs. CTL. Inner medullary aquaporin-2 (AQP2) protein abundance was also markedly decreased in CPT rats vs. CTL. These findings were reversed in CPT-LIM rats, suggesting captopril-induced primary polydipsia. CPT-BKI rats demonstrated parameters no different from CTL despite ad libitum water intake. Mean arterial pressure and 24-h creatinine clearance did not differ among groups. We conclude that ACEI with captopril induces primary polydipsia despite impaired production of the dipsogen ANG II and that this primary increase in water intake is likely the cause of the decreased protein abundance of inner medullary AQP2. Furthermore, this dipsogenic effect was reversed by antagonism of bradykinin, thus implicating this hormone in thirst regulation in the rat." @default.
• W2000856761 created "2016-06-24" @default.
• W2000856761 creator A5001163609 @default.
• W2000856761 creator A5009700893 @default.
• W2000856761 creator A5059705829 @default.
• W2000856761 creator A5065041140 @default.
• W2000856761 creator A5080421561 @default.
• W2000856761 creator A5086649279 @default.
• W2000856761 creator A5088279175 @default.
• W2000856761 date "2004-05-01" @default.
• W2000856761 modified "2023-10-16" @default.
• W2000856761 title "Evidence for bradykinin as a stimulator of thirst" @default.
• W2000856761 cites W1970161978 @default.
• W2000856761 cites W1981009199 @default.
• W2000856761 cites W1986665743 @default.
• W2000856761 cites W2031589036 @default.
• W2000856761 cites W2032614102 @default.
• W2000856761 cites W2033204727 @default.
• W2000856761 cites W2042776325 @default.
• W2000856761 cites W2048016858 @default.
• W2000856761 cites W2052426295 @default.
• W2000856761 cites W2061702821 @default.
• W2000856761 cites W2064320685 @default.
• W2000856761 cites W2066104567 @default.
• W2000856761 cites W2073774382 @default.
• W2000856761 cites W2074660192 @default.
• W2000856761 cites W2086382158 @default.
• W2000856761 cites W2087274232 @default.
• W2000856761 cites W2088308421 @default.
• W2000856761 cites W2101314260 @default.
• W2000856761 cites W2165540926 @default.
• W2000856761 cites W2172465647 @default.
• W2000856761 cites W2173642814 @default.
• W2000856761 cites W2297036724 @default.
• W2000856761 cites W2414861285 @default.
• W2000856761 cites W3023811647 @default.
• W2000856761 doi "https://doi.org/10.1152/ajprenal.00243.2003" @default.
• W2000856761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15075183" @default.
• W2000856761 hasPublicationYear "2004" @default.
• W2000856761 type Work @default.
• W2000856761 sameAs 2000856761 @default.
• W2000856761 citedByCount "15" @default.
• W2000856761 countsByYear W20008567612012 @default.
• W2000856761 countsByYear W20008567612014 @default.
• W2000856761 countsByYear W20008567612015 @default.
• W2000856761 countsByYear W20008567612016 @default.
• W2000856761 countsByYear W20008567612019 @default.
• W2000856761 countsByYear W20008567612020 @default.
• W2000856761 countsByYear W20008567612021 @default.
• W2000856761 crossrefType "journal-article" @default.
• W2000856761 hasAuthorship W2000856761A5001163609 @default.
• W2000856761 hasAuthorship W2000856761A5009700893 @default.
• W2000856761 hasAuthorship W2000856761A5059705829 @default.
• W2000856761 hasAuthorship W2000856761A5065041140 @default.
• W2000856761 hasAuthorship W2000856761A5080421561 @default.
• W2000856761 hasAuthorship W2000856761A5086649279 @default.
• W2000856761 hasAuthorship W2000856761A5088279175 @default.
• W2000856761 hasBestOaLocation W20008567612 @default.
• W2000856761 hasConcept C126322002 @default.
• W2000856761 hasConcept C134018914 @default.
• W2000856761 hasConcept C170493617 @default.
• W2000856761 hasConcept C185592680 @default.
• W2000856761 hasConcept C27016395 @default.
• W2000856761 hasConcept C2776370428 @default.
• W2000856761 hasConcept C2778534349 @default.
• W2000856761 hasConcept C2778713406 @default.
• W2000856761 hasConcept C2779479957 @default.
• W2000856761 hasConcept C2779591629 @default.
• W2000856761 hasConcept C2779624480 @default.
• W2000856761 hasConcept C2780180277 @default.
• W2000856761 hasConcept C2908929049 @default.
• W2000856761 hasConcept C555293320 @default.
• W2000856761 hasConcept C71924100 @default.
• W2000856761 hasConcept C84393581 @default.
• W2000856761 hasConceptScore W2000856761C126322002 @default.
• W2000856761 hasConceptScore W2000856761C134018914 @default.
• W2000856761 hasConceptScore W2000856761C170493617 @default.
• W2000856761 hasConceptScore W2000856761C185592680 @default.
• W2000856761 hasConceptScore W2000856761C27016395 @default.
• W2000856761 hasConceptScore W2000856761C2776370428 @default.
• W2000856761 hasConceptScore W2000856761C2778534349 @default.
• W2000856761 hasConceptScore W2000856761C2778713406 @default.
• W2000856761 hasConceptScore W2000856761C2779479957 @default.
• W2000856761 hasConceptScore W2000856761C2779591629 @default.
• W2000856761 hasConceptScore W2000856761C2779624480 @default.
• W2000856761 hasConceptScore W2000856761C2780180277 @default.
• W2000856761 hasConceptScore W2000856761C2908929049 @default.
• W2000856761 hasConceptScore W2000856761C555293320 @default.
• W2000856761 hasConceptScore W2000856761C71924100 @default.
• W2000856761 hasConceptScore W2000856761C84393581 @default.
• W2000856761 hasIssue "5" @default.
• W2000856761 hasLocation W20008567611 @default.
• W2000856761 hasLocation W20008567612 @default.
• W2000856761 hasLocation W20008567613 @default.
• W2000856761 hasOpenAccess W2000856761 @default.
• W2000856761 hasPrimaryLocation W20008567611 @default.
• W2000856761 hasRelatedWork W1979258691 @default.
• W2000856761 hasRelatedWork W2000856761 @default.

• next