Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000858754> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2000858754 endingPage "43" @default.
- W2000858754 startingPage "37" @default.
- W2000858754 abstract "Long-chain acylcarnitines, such as palmitoylcarnitine chloride (PCC), are endogenous compounds which have been shown to increase intestinal transport of small hydrophilic compounds (including some pharmaceutical agents) through the paracellular pathway. However, the size range of the compounds whose absorption can be improved by PCC has not been fully investigated. In the present study, we systematically examined the effect of PCC on the transport rate of a series of hydrophilic fluorescent model compounds of varying molecular weights (0.3-71.2 kD) across cultured monolayers of the human intestinal epithelial cells Caco-2. Mucosal addition of 100 or 200 microM PCC resulted in comparable time-dependent decreases in the transepithelial electric resistance (T1/2, approximately 15 min). PCC addition induced a striking increase in the transport of sodium fluorescein (Flu-Na; 0.3 kD) and a slight or moderate increase in transports of fluorescent compounds of 0.6-11 kD. The effect of PCC on transport of compounds with molecular weights of > or = 17 kD appeared to be negligible. Examination by confocal laser scanning microscopy clearly revealed dilated paracellular spaces in Caco-2 monolayers which had been mucosally pretreated with PCC, confirming that PCC increases intestinal permeability by opening a paracellular transport pathway. Our results suggest that PCC is particularly effective in enhancing intestinal absorption of small hydrophilic compound like Flu-Na and may also have limited use in promoting the transport of compounds of < or = 10 kD." @default.
- W2000858754 created "2016-06-24" @default.
- W2000858754 creator A5001799671 @default.
- W2000858754 creator A5003503432 @default.
- W2000858754 creator A5017569327 @default.
- W2000858754 creator A5019318627 @default.
- W2000858754 creator A5036409734 @default.
- W2000858754 date "1998-01-01" @default.
- W2000858754 modified "2023-09-27" @default.
- W2000858754 title "Molecular Weight-Dependent Paracellular Transport of Fluorescent Model Compounds Induced by Palmitoylcarnitine Chloride across the Human Intestinal Epithelial Cell Line Caco-2" @default.
- W2000858754 cites W134089957 @default.
- W2000858754 cites W1980996827 @default.
- W2000858754 cites W1993984872 @default.
- W2000858754 cites W2006149132 @default.
- W2000858754 cites W2019374792 @default.
- W2000858754 cites W2037372433 @default.
- W2000858754 cites W2102083512 @default.
- W2000858754 cites W4232529163 @default.
- W2000858754 cites W53654856 @default.
- W2000858754 doi "https://doi.org/10.3109/10611869808997879" @default.
- W2000858754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9769019" @default.
- W2000858754 hasPublicationYear "1998" @default.
- W2000858754 type Work @default.
- W2000858754 sameAs 2000858754 @default.
- W2000858754 citedByCount "14" @default.
- W2000858754 countsByYear W20008587542012 @default.
- W2000858754 countsByYear W20008587542014 @default.
- W2000858754 countsByYear W20008587542016 @default.
- W2000858754 crossrefType "journal-article" @default.
- W2000858754 hasAuthorship W2000858754A5001799671 @default.
- W2000858754 hasAuthorship W2000858754A5003503432 @default.
- W2000858754 hasAuthorship W2000858754A5017569327 @default.
- W2000858754 hasAuthorship W2000858754A5019318627 @default.
- W2000858754 hasAuthorship W2000858754A5036409734 @default.
- W2000858754 hasConcept C120882062 @default.
- W2000858754 hasConcept C121332964 @default.
- W2000858754 hasConcept C125287762 @default.
- W2000858754 hasConcept C12554922 @default.
- W2000858754 hasConcept C126322002 @default.
- W2000858754 hasConcept C185592680 @default.
- W2000858754 hasConcept C193176779 @default.
- W2000858754 hasConcept C202751555 @default.
- W2000858754 hasConcept C24890656 @default.
- W2000858754 hasConcept C3019368612 @default.
- W2000858754 hasConcept C41625074 @default.
- W2000858754 hasConcept C55493867 @default.
- W2000858754 hasConcept C60903277 @default.
- W2000858754 hasConcept C62520636 @default.
- W2000858754 hasConcept C71924100 @default.
- W2000858754 hasConcept C86803240 @default.
- W2000858754 hasConcept C91881484 @default.
- W2000858754 hasConceptScore W2000858754C120882062 @default.
- W2000858754 hasConceptScore W2000858754C121332964 @default.
- W2000858754 hasConceptScore W2000858754C125287762 @default.
- W2000858754 hasConceptScore W2000858754C12554922 @default.
- W2000858754 hasConceptScore W2000858754C126322002 @default.
- W2000858754 hasConceptScore W2000858754C185592680 @default.
- W2000858754 hasConceptScore W2000858754C193176779 @default.
- W2000858754 hasConceptScore W2000858754C202751555 @default.
- W2000858754 hasConceptScore W2000858754C24890656 @default.
- W2000858754 hasConceptScore W2000858754C3019368612 @default.
- W2000858754 hasConceptScore W2000858754C41625074 @default.
- W2000858754 hasConceptScore W2000858754C55493867 @default.
- W2000858754 hasConceptScore W2000858754C60903277 @default.
- W2000858754 hasConceptScore W2000858754C62520636 @default.
- W2000858754 hasConceptScore W2000858754C71924100 @default.
- W2000858754 hasConceptScore W2000858754C86803240 @default.
- W2000858754 hasConceptScore W2000858754C91881484 @default.
- W2000858754 hasIssue "1" @default.
- W2000858754 hasLocation W20008587541 @default.
- W2000858754 hasLocation W20008587542 @default.
- W2000858754 hasOpenAccess W2000858754 @default.
- W2000858754 hasPrimaryLocation W20008587541 @default.
- W2000858754 hasRelatedWork W1962589009 @default.
- W2000858754 hasRelatedWork W1968578344 @default.
- W2000858754 hasRelatedWork W1971517729 @default.
- W2000858754 hasRelatedWork W1992672155 @default.
- W2000858754 hasRelatedWork W2028950112 @default.
- W2000858754 hasRelatedWork W2056376462 @default.
- W2000858754 hasRelatedWork W2071464010 @default.
- W2000858754 hasRelatedWork W2084814088 @default.
- W2000858754 hasRelatedWork W2089728333 @default.
- W2000858754 hasRelatedWork W2117586435 @default.
- W2000858754 hasVolume "6" @default.
- W2000858754 isParatext "false" @default.
- W2000858754 isRetracted "false" @default.
- W2000858754 magId "2000858754" @default.
- W2000858754 workType "article" @default.