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- W2000861514 abstract "Developing central dopamine (DA)-containing neurons in rotation-mediated reaggregate tissue culture exposed to 10(-4) M methamphetamine for 1 week (at a time corresponding to the 2nd week of postnatal development) exhibit decreased DA levels. DA neurons were visualized either by a histofluorescent method after 'loading' with exogenous DA, or by tyrosine hydroxylase (TH) immunocytochemistry. An apparent loss of histofluorescent DA cell bodies was observed due to a methamphetamine-induced reduction in exogenous DA accumulation. No decrease in the number of TH-immunoreactive neurons was observed. Thus, developing DA neurons when visualized by TH immunocytochemistry survive despite methamphetamine-induced reductions in DA levels." @default.
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- W2000861514 date "1991-08-01" @default.
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- W2000861514 title "Survival of developing dopaminergic neurons in reaggregate tissue culture following treatment with methamphetamine" @default.
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- W2000861514 doi "https://doi.org/10.1016/0304-3940(91)90474-8" @default.
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