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• W2000863197 abstract "No AccessJournal of UrologyInvestigative Urology1 Dec 1998ELECTROACUPUNCTURE DECREASES C-FOS EXPRESSION IN THE SPINAL CORD INDUCED BY NOXIOUS STIMULATION OF THE RAT BLADDER CARL J. CHANG, SHIH-TSUNG HUANG, KENNETH HSU, AUSTIN LIN, MARSHALL L. STOLLER, and TOM F. LUE CARL J. CHANGCARL J. CHANG More articles by this author , SHIH-TSUNG HUANGSHIH-TSUNG HUANG More articles by this author , KENNETH HSUKENNETH HSU More articles by this author , AUSTIN LINAUSTIN LIN More articles by this author , MARSHALL L. STOLLERMARSHALL L. STOLLER More articles by this author , and TOM F. LUETOM F. LUE More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62309-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The present study investigated the effects of noxious stimulation of the lower urinary tract on neuronal fos protein expression in the spinal micturition center of rats and also examined the effects of electroacupuncture (EA) on fos expression induced by noxious stimulation of the lower urinary tract. Materials and Methods: Experiments were conducted on 21 female Sprague-Dawley rats divided into four groups. Group 1 rats (n = 5) served as normal controls. Group 2 rats (n = 5) received EA at the Sanyinjiao acupoint. Group 3 animals (n = 6) were catheterized through the urethra and instilled with 1% acetic acid, and group 4 (n = 5) animals received EA 1 hour before 1% acetic acid instillation. All animals underwent arterial perfusion, laminectomy, and spinal cord removal. Spinal cords were sectioned and processed for immunohistochemical staining for fos protein. Results: No fos protein was detected in any spinal neurons in normal control animals, and either none or few (0 to 4 cells/section) fos-immunoreactive (fos-IR) cells were seen in animals treated with EA. Noxious stimulation of the lower urinary tract with 1% acetic acid drastically increased the number of fos-IR neurons (30 to 127 cells/L6 section, mean 76.17 +/− 13.98; 28 to 77, cells/S1 section, mean 59 +/− 8.30; 7 to 35 cells/S2 section, mean 19.83 +/− 4.10). However, EA administered 1 hour before 1% acetic acid instillation significantly decreased the number of fos-IR neurons resulting from chemical irritation (0 to 50 cells/L6 section, mean 19.8 +/− 9.33; 0 to 47 cells/S1 section, mean 13.2 +/− 9.12; 0 to 37 cells/S2 section, mean 13.6 +/− 7.31). Conclusions: Our study demonstrates that bladder instillation with 1% acetic acid induces fos protein expression in the spinal micturition center of the rat and that electroacupuncture can reduce this expression. These results suggest a link between electroacupuncture and reduction in spinal neuronal cell activity. References 1 : Acupuncture past and present. Physiotherapy1978; 64: 203. Google Scholar 2 : Electrotherapy for acceleration of wound healing: low intensity direct current. Arch. Phys. Med. Rehabil.1985; 66: 443. Google Scholar 3 : Electrical stimulation of the gastrocnemius muscle in the spontaneously hypertensive rat increases the pain threshold: role of different serotonergic receptors. Acta Physiol. Scand.1990; 138: 125. Google Scholar 4 : Acupuncture -from empiricism to science: functional background to acupuncture effects in pain and disease. Med. Hypotheses1995; 45: 271. 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Google Scholar 23 : Stimulus-transcription coupling the nervous system: involvement of the inducible proto-oncogenes fos and jun. Ann. Rev. Neurosci.1991; 14: 421. Google Scholar 24 : Specific temporal and spatial distribution of JUN, FOS, and KROX-24 proteins in spinal neurons following noxious transsynaptic stimulation. J. Comp. Neurol.1991; 313: 178. Google Scholar 25 : Electrophysiological study of micturition reflexes in rats. Experientia1989; 42: 109. Google Scholar 26 : The fos proto-oncogene protein: regulation by morphine in the rat hypothalamus. Life Sci.1990; 46: 1825. Google Scholar 27 : Systemic morphine suppresses noxious stimulus-evoked fos protein-like immunoreactivity in the rat spinal cord. J. Neurosci.1990; 10: 323. Google Scholar From the Department of Urology, School of Medicine, University of California at San Francisco, San Francisco, CA© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byWANG Y and HASSOUNA M (2018) NEUROMODULATION REDUCES C-FOS GENE EXPRESSION IN SPINALIZED RATS: A DOUBLE-BLIND RANDOMIZED STUDYJournal of Urology, VOL. 163, NO. 6, (1966-1970), Online publication date: 1-Jun-2000. Volume 160Issue 6 Part 1December 1998Page: 2274-2279 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information CARL J. CHANG More articles by this author SHIH-TSUNG HUANG More articles by this author KENNETH HSU More articles by this author AUSTIN LIN More articles by this author MARSHALL L. STOLLER More articles by this author TOM F. LUE More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2000863197 title "ELECTROACUPUNCTURE DECREASES C-FOS EXPRESSION IN THE SPINAL CORD INDUCED BY NOXIOUS STIMULATION OF THE RAT BLADDER" @default.
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