FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000865194> ?p ?o ?g. }

• W2000865194 endingPage "200" @default.
• W2000865194 startingPage "197" @default.
• W2000865194 abstract "Purpose: Use of fluoroquinolone agents as single drug treatment for severe bacterial keratitis requires that adequate stromal drug concentrations are achievable that exceed the MIC9o for common corneal pathogens. The purpose of this study, therefore, is to document the human stromal penetration of the fluoroquinolone, Ciprofloxacin, in human tissue obtained from patients undergoing penetrating keratoplasty. Methods: Twelve patients, all with intact corneal epithelia, received 0.3% Ciprofloxacin (Ciloxan) eyedrops every 15 minutes for the first hour and then every hour for 10 hours before their scheduled keratoplasty. Corneal tissue samples obtained from the excised buttons at the time of surgery were frozen and subsequently analyzed for drug concentration using high-pressure liquid chromatography. Results: A mean corneal tissue concentration of 5.28 ± 3.4 μg/g tissue (mean + standard deviation) of Ciprofloxacin was determined. Tissue levels ranged from 1.43 μg/g of tissue to 10.58 μg/g of tissue. Conclusion: Ciprofloxacin penetration was variable in patients with an intact epithelium and, in some cases, did not exceed the MIC90 for some gram-positive organisms. The presence of an epithelial defect is expected to potentiate the penetration of Ciprofloxacin to most likely exceed the MIC90 for most corneal pathogens. Purpose: Use of fluoroquinolone agents as single drug treatment for severe bacterial keratitis requires that adequate stromal drug concentrations are achievable that exceed the MIC9o for common corneal pathogens. The purpose of this study, therefore, is to document the human stromal penetration of the fluoroquinolone, Ciprofloxacin, in human tissue obtained from patients undergoing penetrating keratoplasty. Methods: Twelve patients, all with intact corneal epithelia, received 0.3% Ciprofloxacin (Ciloxan) eyedrops every 15 minutes for the first hour and then every hour for 10 hours before their scheduled keratoplasty. Corneal tissue samples obtained from the excised buttons at the time of surgery were frozen and subsequently analyzed for drug concentration using high-pressure liquid chromatography. Results: A mean corneal tissue concentration of 5.28 ± 3.4 μg/g tissue (mean + standard deviation) of Ciprofloxacin was determined. Tissue levels ranged from 1.43 μg/g of tissue to 10.58 μg/g of tissue. Conclusion: Ciprofloxacin penetration was variable in patients with an intact epithelium and, in some cases, did not exceed the MIC90 for some gram-positive organisms. The presence of an epithelial defect is expected to potentiate the penetration of Ciprofloxacin to most likely exceed the MIC90 for most corneal pathogens." @default.
• W2000865194 created "2016-06-24" @default.
• W2000865194 creator A5015264992 @default.
• W2000865194 creator A5039917618 @default.
• W2000865194 creator A5057608455 @default.
• W2000865194 creator A5070764312 @default.
• W2000865194 date "1993-02-01" @default.
• W2000865194 modified "2023-10-16" @default.
• W2000865194 title "Corneal Stromal Penetration of Topical Ciprofloxacin in Humans" @default.
• W2000865194 cites W1970404985 @default.
• W2000865194 cites W1991533929 @default.
• W2000865194 cites W4247139116 @default.
• W2000865194 cites W4253976107 @default.
• W2000865194 doi "https://doi.org/10.1016/s0161-6420(13)31672-8" @default.
• W2000865194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8437827" @default.
• W2000865194 hasPublicationYear "1993" @default.
• W2000865194 type Work @default.
• W2000865194 sameAs 2000865194 @default.
• W2000865194 citedByCount "38" @default.
• W2000865194 countsByYear W20008651942018 @default.
• W2000865194 countsByYear W20008651942023 @default.
• W2000865194 crossrefType "journal-article" @default.
• W2000865194 hasAuthorship W2000865194A5015264992 @default.
• W2000865194 hasAuthorship W2000865194A5039917618 @default.
• W2000865194 hasAuthorship W2000865194A5057608455 @default.
• W2000865194 hasAuthorship W2000865194A5070764312 @default.
• W2000865194 hasConcept C118487528 @default.
• W2000865194 hasConcept C127413603 @default.
• W2000865194 hasConcept C142724271 @default.
• W2000865194 hasConcept C16930146 @default.
• W2000865194 hasConcept C2776882836 @default.
• W2000865194 hasConcept C2778512257 @default.
• W2000865194 hasConcept C2778560704 @default.
• W2000865194 hasConcept C2779257441 @default.
• W2000865194 hasConcept C2780035454 @default.
• W2000865194 hasConcept C42475967 @default.
• W2000865194 hasConcept C501593827 @default.
• W2000865194 hasConcept C71924100 @default.
• W2000865194 hasConcept C80107235 @default.
• W2000865194 hasConcept C86803240 @default.
• W2000865194 hasConcept C89423630 @default.
• W2000865194 hasConcept C98274493 @default.
• W2000865194 hasConceptScore W2000865194C118487528 @default.
• W2000865194 hasConceptScore W2000865194C127413603 @default.
• W2000865194 hasConceptScore W2000865194C142724271 @default.
• W2000865194 hasConceptScore W2000865194C16930146 @default.
• W2000865194 hasConceptScore W2000865194C2776882836 @default.
• W2000865194 hasConceptScore W2000865194C2778512257 @default.
• W2000865194 hasConceptScore W2000865194C2778560704 @default.
• W2000865194 hasConceptScore W2000865194C2779257441 @default.
• W2000865194 hasConceptScore W2000865194C2780035454 @default.
• W2000865194 hasConceptScore W2000865194C42475967 @default.
• W2000865194 hasConceptScore W2000865194C501593827 @default.
• W2000865194 hasConceptScore W2000865194C71924100 @default.
• W2000865194 hasConceptScore W2000865194C80107235 @default.
• W2000865194 hasConceptScore W2000865194C86803240 @default.
• W2000865194 hasConceptScore W2000865194C89423630 @default.
• W2000865194 hasConceptScore W2000865194C98274493 @default.
• W2000865194 hasIssue "2" @default.
• W2000865194 hasLocation W20008651941 @default.
• W2000865194 hasLocation W20008651942 @default.
• W2000865194 hasOpenAccess W2000865194 @default.
• W2000865194 hasPrimaryLocation W20008651941 @default.
• W2000865194 hasRelatedWork W159790513 @default.
• W2000865194 hasRelatedWork W169938723 @default.
• W2000865194 hasRelatedWork W1978042118 @default.
• W2000865194 hasRelatedWork W1997902205 @default.
• W2000865194 hasRelatedWork W2051298974 @default.
• W2000865194 hasRelatedWork W2077844465 @default.
• W2000865194 hasRelatedWork W2090997908 @default.
• W2000865194 hasRelatedWork W2163958179 @default.
• W2000865194 hasRelatedWork W2405582009 @default.
• W2000865194 hasRelatedWork W2408260385 @default.
• W2000865194 hasVolume "100" @default.
• W2000865194 isParatext "false" @default.
• W2000865194 isRetracted "false" @default.
• W2000865194 magId "2000865194" @default.
• W2000865194 workType "article" @default.