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- W2000865322 abstract "Summary The marginal zone of human spleens is regarded as an organ‐specific region harbouring sessile memory B cells. This opinion has arisen by extrapolating from results obtained in mice and rats. Detection of CD27 + B cells in situ now revealed similarities among the most superficial region of B‐cell follicles in human spleens, reactive lymph nodes, inflamed appendices, tonsils and terminal ilea. The follicular surface in these organs consists of small naïve immunoglobulin D (IgD) + CD27 – B cells predominating in an inner area and larger IgD +/– CD27 + B cells prevailing in a more superficial position. CD27 + B cells may, however, also occupy the entire follicular periphery around the germinal centre. Together with additional peculiarities this distribution indicates a fundamental microanatomical difference among the human and rodent splenic white pulp. We hypothesize that the follicular periphery represents a recirculation compartment both for naïve and memory/natural reactive B cells in all human secondary lymphatic organs. This assumption implies a difference in recirculation behaviour among human and rodent B memory cells." @default.
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- W2000865322 date "2005-09-28" @default.
- W2000865322 modified "2023-10-15" @default.
- W2000865322 title "CD27+ B cells in human lymphatic organs: re-evaluating the splenic marginal zone" @default.
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- W2000865322 doi "https://doi.org/10.1111/j.1365-2567.2005.02242.x" @default.
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