FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000868637> ?p ?o ?g. }

• W2000868637 abstract "Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CABackground: Approximately half of the colorectal cancer (CRC) patients develop metastatic disease, either at diagnosis or during follow-up. 5-FU-based chemotherapy forms the backbone of treatment in these patients. However, the response to this therapy varies between individuals. Therefore, an important challenge in CRC research is to identify biomarkers that are predictive of this response.MicroRNAs are short RNAs that post-transcriptionally regulate the gene expression of many genes. MicroRNA levels are frequently altered in cancer, and can affect expression of genes that modulate tumorigenesis.Objective: In this study, we explore the potential of microRNAs, and the microRNA producing protein Dicer, as biomarkers that can predict chemo-sensitivity in patients with metastatic colorectal cancer.Methods: We analyzed the levels of a selected panel of 22 miRNAs and the Dicer protein in primary CRC tumors from patients enrolled in the CAIRO study (a phase III study of the Dutch Colorectal Cancer Group). MiRNA levels were determined with Taqman microRNA assays and Dicer level with immunohistochemistry. Correlation between the expression status of microRNAs or Dicer in primary tumors and the progression free survival (PFS) were investigated. In addition, we evaluated correlations between Dicer and miRNA levels.Results: Variable Dicer intensities were observed among the analyzed samples, but there was no significant association between Dicer levels and PFS. In addition, no clear correlation between Dicer and miRNA levels could be identified. We especially detected higher expression of miR-31 and miR-21 in tumors compared to matched normal tissue, whereas miR-137 and miR-215 were lower expressed. Interestingly, miR-143 expression was reduced in a subset of the primary CRC tumors, and this differential expression showed a relationship with PFS. The group with reduced miR-143 expression showed higher PFS. The median PFS for patients with reduced, neutral and increased miR-143 expression was 261, 167 and 142 days, respectively (p-value log-rank test=0.018).Conclusion: The expression level of miR-143 may have clinical utility as a biomarker for response to 5-FU-based chemotherapy. These findings warrant further studies to investigate the relationship between miR-143 expression and 5-FU.Citation Format: Femke Simmer, Jeroen Dijkstra, Sabine Venderbosch, Claudius Faber, Leonie Mekenkamp, Miriam Koopman, Ton de Haan, Cornelis Punt, Iris Nagtegaal. MicroRNA-143 is a putative predictive biomarker for 5-FU-based chemotherapy in patients with metastatic colorectal cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 534. doi:10.1158/1538-7445.AM2014-534" @default.
• W2000868637 created "2016-06-24" @default.
• W2000868637 creator A5004189214 @default.
• W2000868637 creator A5009163927 @default.
• W2000868637 creator A5033076463 @default.
• W2000868637 creator A5036695973 @default.
• W2000868637 creator A5043942519 @default.
• W2000868637 creator A5046706345 @default.
• W2000868637 creator A5048681172 @default.
• W2000868637 creator A5055636837 @default.
• W2000868637 creator A5061172196 @default.
• W2000868637 date "2014-09-30" @default.
• W2000868637 modified "2023-09-25" @default.
• W2000868637 title "Abstract 534: MicroRNA-143 is a putative predictive biomarker for 5-FU-based chemotherapy in patients with metastatic colorectal cancer" @default.
• W2000868637 doi "https://doi.org/10.1158/1538-7445.am2014-534" @default.
• W2000868637 hasPublicationYear "2014" @default.
• W2000868637 type Work @default.
• W2000868637 sameAs 2000868637 @default.
• W2000868637 citedByCount "0" @default.
• W2000868637 crossrefType "proceedings-article" @default.
• W2000868637 hasAuthorship W2000868637A5004189214 @default.
• W2000868637 hasAuthorship W2000868637A5009163927 @default.
• W2000868637 hasAuthorship W2000868637A5033076463 @default.
• W2000868637 hasAuthorship W2000868637A5036695973 @default.
• W2000868637 hasAuthorship W2000868637A5043942519 @default.
• W2000868637 hasAuthorship W2000868637A5046706345 @default.
• W2000868637 hasAuthorship W2000868637A5048681172 @default.
• W2000868637 hasAuthorship W2000868637A5055636837 @default.
• W2000868637 hasAuthorship W2000868637A5061172196 @default.
• W2000868637 hasConcept C104317684 @default.
• W2000868637 hasConcept C121608353 @default.
• W2000868637 hasConcept C126322002 @default.
• W2000868637 hasConcept C143998085 @default.
• W2000868637 hasConcept C145059251 @default.
• W2000868637 hasConcept C166703698 @default.
• W2000868637 hasConcept C2779013556 @default.
• W2000868637 hasConcept C2779867133 @default.
• W2000868637 hasConcept C2781197716 @default.
• W2000868637 hasConcept C502942594 @default.
• W2000868637 hasConcept C526805850 @default.
• W2000868637 hasConcept C54355233 @default.
• W2000868637 hasConcept C555283112 @default.
• W2000868637 hasConcept C67705224 @default.
• W2000868637 hasConcept C71924100 @default.
• W2000868637 hasConcept C86803240 @default.
• W2000868637 hasConceptScore W2000868637C104317684 @default.
• W2000868637 hasConceptScore W2000868637C121608353 @default.
• W2000868637 hasConceptScore W2000868637C126322002 @default.
• W2000868637 hasConceptScore W2000868637C143998085 @default.
• W2000868637 hasConceptScore W2000868637C145059251 @default.
• W2000868637 hasConceptScore W2000868637C166703698 @default.
• W2000868637 hasConceptScore W2000868637C2779013556 @default.
• W2000868637 hasConceptScore W2000868637C2779867133 @default.
• W2000868637 hasConceptScore W2000868637C2781197716 @default.
• W2000868637 hasConceptScore W2000868637C502942594 @default.
• W2000868637 hasConceptScore W2000868637C526805850 @default.
• W2000868637 hasConceptScore W2000868637C54355233 @default.
• W2000868637 hasConceptScore W2000868637C555283112 @default.
• W2000868637 hasConceptScore W2000868637C67705224 @default.
• W2000868637 hasConceptScore W2000868637C71924100 @default.
• W2000868637 hasConceptScore W2000868637C86803240 @default.
• W2000868637 hasLocation W20008686371 @default.
• W2000868637 hasOpenAccess W2000868637 @default.
• W2000868637 hasPrimaryLocation W20008686371 @default.
• W2000868637 hasRelatedWork W1538393364 @default.
• W2000868637 hasRelatedWork W1706289333 @default.
• W2000868637 hasRelatedWork W1976199989 @default.
• W2000868637 hasRelatedWork W2005816860 @default.
• W2000868637 hasRelatedWork W2029778127 @default.
• W2000868637 hasRelatedWork W2035264474 @default.
• W2000868637 hasRelatedWork W2069195853 @default.
• W2000868637 hasRelatedWork W2076426743 @default.
• W2000868637 hasRelatedWork W2157609508 @default.
• W2000868637 hasRelatedWork W2322577068 @default.
• W2000868637 hasRelatedWork W2355827939 @default.
• W2000868637 hasRelatedWork W2439955832 @default.
• W2000868637 hasRelatedWork W2538770802 @default.
• W2000868637 hasRelatedWork W2807169763 @default.
• W2000868637 hasRelatedWork W2975077728 @default.
• W2000868637 hasRelatedWork W3000239856 @default.
• W2000868637 hasRelatedWork W3045434474 @default.
• W2000868637 hasRelatedWork W3185536891 @default.
• W2000868637 hasRelatedWork W3196533352 @default.
• W2000868637 hasRelatedWork W569789217 @default.
• W2000868637 isParatext "false" @default.
• W2000868637 isRetracted "false" @default.
• W2000868637 magId "2000868637" @default.
• W2000868637 workType "article" @default.