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- W2000870832 abstract "26,26,26,27,27,27-Hexafluo-1,25(OH)2 vitamin D3, the hexafluorinated analog of 1,25(OH)2 vitamin D3, has been reported to be several times more potent than the parent compound regarding some vitamin D actions. The reason for enhanced biologic activity in the kidneys and small intestine appears to be related to F6-1,25(OH)2 vitamin D3 metabolism to ST-232, 26,26,26,27,27,27-hexafluoro-1α,23S,25-trihydroxyvitamin D3, a bioactive 23S-hydroxylated form that is resistant to further metabolism. Since F6-1,25(OH)2 vitamin D3 is considered to prevent osteoporotic decrease in bone mass by suppressing bone turnover, we here compared the distribution and metabolism of [1β-3H]F6-1,25(OH)2 vitamin D3 and [1β-3H]1,25(OH)2 vitamin D3 in bones of rats by autoradiography and radio-HPLC. In the dosed groups, radioactivity was detected locally in the metaphysis, the modeling site in bones. As compared with the [1β-3H]1,25(OH)2 vitamin D3 case, [1β-3H]F6-1,25(OH)2 vitamin D3 was significantly retained in this site, and moreover, it mainly persisted as unchanged compound and ST-232. These findings indicate that the reason for the higher potency of F6-1,25(OH)2 vitamin D3 than 1,25(OH)2 vitamin D3 in bones are linked with increased distribution and reduced metabolism." @default.
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- W2000870832 date "1998-10-01" @default.
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- W2000870832 title "Distribution and metabolism of F 6 -1,25(OH) 2 Vitamin D 3 and 1,25(OH) 2 Vitamin D 3 in the bones of rats dosed with tritium-labeled compounds" @default.
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- W2000870832 doi "https://doi.org/10.1016/s0039-128x(98)00055-5" @default.
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